Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.
Depression: early-phase trial registry
245 of 687 indexed Depression trials are currently recruiting, with more weight in Phase 1-2.
Corpus placement: #5 of 28,707 conditions by registered trial count.
687 US clinical trials · 245 currently recruiting · #5 of 28,707 conditions by registered trial count
Depression: 687 US clinical trials tracked, 245 recruiting.
Depression is the subject of 687 registered US clinical trials on ClinicalTrials.gov, 245 of them currently open to new participants. 70 are in Phase 3-4 (later-stage) and 111 in Phase 1-2 (earlier-stage). The most active sponsor is Massachusetts General Hospital, running 29 of these trials.
Enrollment posture brief
Registry condition depression
OPEN 245 | RECR 36% | LATE 70 | EARLY 111 | RANK #5 | SPON 29
Volume-matched condition peers
Nearest open-share peer: Pancreatic Cancer (36% recruiting · 283 trials)
Depression lists 245 open slots (36% of 687 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Depression on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Depression recruits in line with its size-band peers.
245 of 687 indexed trials (35.7%) are open to enrollment, against a 37.1% average across 139 conditions with 100+ trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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Sponsorship of Depression trials is spread across many organizations.
Massachusetts General Hospital accounts for 29 of 687 trials (4.2%). 231 distinct sponsors appear on at least one study for this condition label.
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Typical Depression enrolment sits around 100 participants.
Median target enrolment is 100 among the 680 trials that report a genuine target (sentinel values excluded). 331 of those (48.7%) plan for fewer than 100 participants.
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Depression research is mostly interventional.
618 interventional and 69 observational studies make up this index (90% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
687 total, page 8 of 14
Duloxetine Compared to Escitalopram and Placebo in the Treatment of Patients With Depression
Eli Lilly and Company
NCT00073411
The BE WITH Project: A Partially Nested Randomized Control Trial (PN-RCT)
University of Florida
NCT07204444
RCT of a Brief Video Intervention Targeting Peer Inclusion to Reduce Depression-related Stigma in Adolescents
New York State Psychiatric Institute
NCT06360107
Identification and Therapy of Postpartum Depression
University of Pittsburgh
NCT00282776
PCORI-1306-02918 Evaluation of Parent-based Programs to Support Children After Traumatic Injury
Marizen Ramirez
NCT02323204
Using a Preparation and Education Intervention to Reduce Postpartum Depression Among New Mothers (The MADE IT 2 Study)
Icahn School of Medicine at Mount Sinai
NCT00951717
Clinical Study Evaluating Effects of Pharmacogenetic-guided vs Standard-of-Care Treatment on Depression and/or Anxiety
AltheaDx
NCT02878928
TC-5214 as add-on the Treatment of Major Depressive Disorder
Targacept
NCT00692445
Healthy Minds Comparison Study
University of Wisconsin, Madison
NCT06282523
Cognitive Therapy for Recurrent Depression
University of Texas Southwestern Medical Center
NCT00118404
Project SOLVE: Trial of a Brief Digital Problem-solving Intervention
Harvard University
NCT04806321
Depression Screening in Black Churches
Columbia University
NCT04524767
Radicle Revive 24: A Study of Health and Wellness Products on Menopausal Health and Related Health Outcomes
Radicle Science
NCT06749288
Self-Management Program for Persons With Limb Loss
Johns Hopkins Bloomberg School of Public Health
NCT00198692
Telemedicine-Based Collaborative Care to Reduce Rural Disparities
University of Arkansas
NCT00439452
Study to Evaluate the Efficacy and Safety of Armodafinil Treatment as Adjunctive Therapy in Adults With Major Depression Associated With Bipolar I Disorder
Cephalon
NCT01072630
Study on the Efficacy, Safety, and Tolerability of Cariprazine Relative to Placebo in Participants With Bipolar I Depression
Forest Laboratories
NCT02670551
Preventing Persistent Post-Surgical Pain and Dysfunction
Barbara A Rakel
NCT03965897
Moral Injury Symptom Scale/Moral Injury Outcome Scale
AdventHealth
NCT04261751
Prevention of School Dropout for Mexican American Adolescents
Arizona State University
NCT00051727
Exercise Training Versus Drug Therapy for Treating Depression in Older Adults
Duke University
NCT00331305
Physiological Brain Atlas Development
Ohio State University
NCT01210534
Rural Dementia Caregiver Project
University of California, San Francisco
NCT04428112
Pilot Randomized Controlled Trial (RCT): Remote SBIRT Vs. In-Person SBIRT
Medical University of South Carolina
NCT04630249
Early Palliative Care With Standard Care or Standard Care Alone in Improving Quality of Life of Patients With Incurable Lung or Non-colorectal Gastrointestinal Cancer and Their Family Caregivers
Alliance for Clinical Trials in Oncology
NCT02349412
Integrated Model for Promoting Parenting and Early School Readiness in Pediatrics
New York University
NCT02459327
Improving Outcomes of Depression in Primary Care
US Department of Veterans Affairs
NCT00105833
Ethnic Variations in Antidepressant Response
National Institute of Mental Health (NIMH)
NCT00047671
Teen Depression Awareness Project (TDAP)
RAND
NCT00099827
Effectiveness of a Telephone-Delivered Behavioral Treatment to Improve the Quality of Life of Older Adults With HIV
Ohio University
NCT00365690
Parenting Young Children Study
University of Oregon
NCT05180487
Psychotherapy for Depressed Mothers of Psychiatrically Ill Children
University of Pittsburgh
NCT00919594
A Helping Hand Among Low-Income Patients
University of Southern California
NCT02147522
Identifying Factors That Predict Antidepressant Treatment Response
Emory University
NCT00360399
Optimizing Electroconvulsive Therapy for Depression
New York State Psychiatric Institute
NCT00045916
Use of Death Cafes to Prevent Burnout in ICU Healthcare Employees
Tulane University School of Medicine
NCT04347811
Effectiveness of Telephone Versus Face-to-Face CBT in Treating People With Depression
Northwestern University
NCT00498706
Daily Assessment of Mood and Social Media Behaviors Study
Southern Methodist University
NCT04349423
Prevention of Depression in At-Risk Adolescents
Vanderbilt University
NCT00073671
Stepped Telemental Health Care Intervention for Depression
Northwestern University
NCT01906476
Hepatitis C Translating Initiatives for Depression Into Effective Solutions
VA Office of Research and Development
NCT01143896
Primary Prevention of Major Depression in Later Life
University of Maryland, College Park
NCT00326677
The Trauma Recovery and Empowerment Model for Treating Post-Traumatic Stress Disorder in Women
Dartmouth-Hitchcock Medical Center
NCT00183716
Healthy Lifestyle Intervention for High-Risk Minority Pregnant Women
Ohio State University
NCT03416010
Building Recovery By Improving Goals, Habits, and Thoughts
RAND
NCT01191788
Comprehensive vs. Assisted Management of Mood and Pain Symptoms
VA Office of Research and Development
NCT01757301
Depression Management at the Workplace
Florida State University
NCT01013220
Early Detection and Intervention for the Prevention of Psychosis
MaineHealth
NCT00531518
Treatment of Depression in Adults
University of Pittsburgh
NCT00073697
Pragmatic Collaborative Care for Cardiac Inpatients With Depression or Anxiety
Massachusetts General Hospital
NCT03118752
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 41 |
| Phase 2 | 70 |
| Phase 3 | 29 |
| Phase 4 | 41 |
Top Sponsors
Named interventions
Most-linked intervention names on Depression records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Depression trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Depression page
687 registered trials, 245 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 245 Depression trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- Massachusetts General Hospital sponsors the most Depression trials on record, review their full trial history before evaluating a specific study. See Massachusetts General Hospital's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Depression condition card totals 687 registered trials; most-linked intervention Placebo; top US site state California. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.