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NCT04743466 · ClinicalTrials.gov registry record

Evaluation of Association Between Testosterone Levels, Dementia, and Adverse Mental Health Outcomes

A clinical trial of Depression and Malignant Solid Neoplasm, sponsored by M.D. Anderson Cancer Center.

Active
Registry status
1
Enrollment target
1
Study location

NCT04743466: Active study of Depression and Malignant Solid Neoplasm, sponsored by M.D. Anderson Cancer Center.

NCT04743466 is a study of Depression and Malignant Solid Neoplasm that is active but no longer recruiting, run by M.D. Anderson Cancer Center. The registered enrollment target is 1 participants, below the 786-participant average among 679 other Depression trials with a reported enrollment target (100% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.

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The verdict

NCT04743466, a study of Depression and Malignant Solid Neoplasm, is active but no longer recruiting, sponsored by M.D. Anderson Cancer Center.

ACTIVE NOT RECRUITING
Registry status
1 participants
Enrollment target
1
Study location

Study Summary

This study evaluates the association between testosterone levels and risk of dementia and adverse mental health outcomes (e.g. depression and anxiety). It is not known whether low testosterone levels may be associated with an increased risk of dementia. Learning about the association between testosterone levels and risk of dementia may help determine the long-term effects of androgen deprivation therapy and may help improve quality of life.

Primary Outcome

Will utilize genetic variants associated with testosterone levels at genome-wide statistical significance thresholds (P \< 5 x 10-8) in published meta-analyses. Will additionally conduct a genome-wide association study with testosterone values in the UK Biobank. Will construct a weighted genetic risk score based on the strength of each variant's association with testosterone levels in published datasets. The results of the weighted method will be scaled per standard deviation (SD) of testosteron

Conditions Studied

Depression Malignant Solid Neoplasm Hematopoietic and Lymphoid Cell Neoplasm Anxiety Disorder Genetic Disorder

Interventions

  • OTHER Electronic Health Record Review

Study Locations (1)

Texas

  • M D Anderson Cancer Center - Houston

Trial Details

FieldValue
Enrollment Target 1 participants
Start Date 2020-02-13
Est. Completion 2028-11-30
M.D. Anderson Cancer Center

2,692 total trials

What the registry record for NCT04743466 still lists

NCT04743466 is an observational study that tracks outcomes without assigning an intervention. The registry caps enrollment at 1 participants, a relatively small participant target, below the 786-participant average among 679 other Depression trials with a reported enrollment target (100% lower).

The record links to 5 conditions, with Depression appearing as the primary indexed condition, and to 1 intervention - of which Electronic Health Record Review is the first listed.

NCT04743466 reports a single indexed study location in Texas.

Frequently Asked Questions

What is clinical trial NCT04743466 about?

NCT04743466 is a clinical study titled "Evaluation of Association Between Testosterone Levels, Dementia, and Adverse Mental Health Outcomes". This study evaluates the association between testosterone levels and risk of dementia and adverse mental health outcomes (e.g. depression and anxiety). It is not known whether low testosterone levels may be associated with an increased risk of dementia. Learning about the association between testost...

What is the current status of trial NCT04743466?

This trial is currently active not recruiting. The enrollment target is 1 participants. The study started on 2020-02-13. Estimated completion is 2028-11-30.

What conditions does trial NCT04743466 study?

This clinical trial studies the following conditions: Depression, Malignant Solid Neoplasm, Hematopoietic and Lymphoid Cell Neoplasm, Anxiety Disorder, Genetic Disorder.

What interventions are being tested in trial NCT04743466?

The interventions under investigation include: Electronic Health Record Review (OTHER).

Who is sponsoring clinical trial NCT04743466?

This trial is sponsored by M.D. Anderson Cancer Center, which has 2,692 total clinical trials registered on ClinicalTrials.gov.

Where is trial NCT04743466 being conducted?

This trial has 1 study location across Texas. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Learn More About Clinical Trials

Similar trials for Depression

Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.

Where NCT04743466's enrollment target sits among peer trials

1 678th of 679 the lowest of 679 other Depression trials

participants (enrollment target), bucketed by value

Each bar is a band; taller bars hold more other Depression trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.

Source ClinicalTrials.gov registry export · 2026-08-08

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Related registry views

Source: ClinicalTrials.gov NCT04743466, the US trial registry maintained by the National Library of Medicine. NCT04743466 (small enrollment · single site footprint · active not recruiting) retrieved and formatted by PlainTrial, see methodology.