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NCT06639477 · ClinicalTrials.gov registry record · NA
Assessing Improvements in Mood and Sleep Trial
A NA study of Depression and Sleep, sponsored by University of Pittsburgh.
- Recruiting
- Registry status
- NA
- Development phase
- 420
- Enrollment target
- 3
- Study locations
NCT06639477: Recruiting NA study of Depression and Sleep, sponsored by University of Pittsburgh.
NCT06639477 is a NA study of Depression and Sleep that is actively recruiting participants, run by University of Pittsburgh. The registered enrollment target is 420 participants, below the 786-participant average among 679 other Depression trials with a reported enrollment target (47% lower). The trial reports 3 study locations across 3 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06639477, a NA study of Depression and Sleep, is actively recruiting participants, sponsored by University of Pittsburgh.
- RECRUITING
- Registry status
- NA
- Development phase
- 420 participants
- Enrollment target
- 3
- Study locations
Study Summary
This is a multi-site randomized control trial involving people age 55+ years who have current depression symptoms plus another suicide risk indicator (either current suicidal ideation or a past history of attempt). Our goal is evaluate which of two different approaches works best to improve things like trouble sleeping, bad moods, and any suicidality. Participants will complete diagnostic interviews, self-report scales, and wear an actigraphy device for the 8 weeks starting at the baseline visit.
Primary Outcome
The outcome is the rate of clinically significant depression symptom responses six-months post treatment, defined as having ≥50% reduction in pre-treatment depression severity six-months posttreatment. Depression severity will be assessed as total scores from the 14 non-sleep items of the clinician rated GRID Hamilton Depression Rating Scale. Lower scores on the GRID Hamilton would indicate a reduction in depression symptoms.
Conditions Studied
Interventions
- BEHAVIORAL Active Comparator
- OTHER Treatment As Usual
- BEHAVIORAL Active Condition
Study Locations (3)
California
- The Regents of the University of California, Los Angeles - Los Angeles
Georgia
- Augusta University - Augusta
Pennsylvania
- University of Pittsburgh - Pittsburgh
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 420 participants |
| Start Date | 2025-05-20 |
| Est. Completion | 2030-08 |
| Phase | NA |
What NCT06639477 shows while recruiting
NCT06639477 is an interventional study that assigns participants to a tested intervention. The registered 420 participants enrollment target is mid-sized for trials with a published cap, below the 786-participant average among 679 other Depression trials with a reported enrollment target (47% lower).
The record links to 3 conditions, with Depression appearing as the primary indexed condition, and to 3 interventions - of which Active Comparator is the first listed.
NCT06639477 reports a single indexed study location in California, Georgia, Pennsylvania.
Frequently Asked Questions
What is clinical trial NCT06639477 about?
NCT06639477 is a clinical study titled "Assessing Improvements in Mood and Sleep Trial". This is a multi-site randomized control trial involving people age 55+ years who have current depression symptoms plus another suicide risk indicator (either current suicidal ideation or a past history of attempt). Our goal is evaluate which of two different approaches works best to improve things l...
What is the current status of trial NCT06639477?
This trial is currently recruiting. It is a NA study. The enrollment target is 420 participants. The study started on 2025-05-20. Estimated completion is 2030-08.
What conditions does trial NCT06639477 study?
This clinical trial studies the following conditions: Depression, Sleep, Suicidality.
What interventions are being tested in trial NCT06639477?
The interventions under investigation include: Active Comparator (BEHAVIORAL), Treatment As Usual (OTHER), Active Condition (BEHAVIORAL).
Who is sponsoring clinical trial NCT06639477?
This trial is sponsored by University of Pittsburgh, which has 1,238 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06639477 being conducted?
This trial has 3 study locations across California, Georgia, Pennsylvania. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Depression
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT06639477's enrollment target sits among peer trials
420 99th of 679 higher than 581 of 679 other Depression trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Depression trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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