Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT02751320 · ClinicalTrials.gov registry record · NA
Efficacy of Three Toothpastes Using an in Situ Caries Model
A NA study of Dental Caries, sponsored by GlaxoSmithKline.
- Completed
- Registry status
- NA
- Development phase
- 58
- Enrollment target
- 1
- Study location
NCT02751320: Completed NA study of Dental Caries, sponsored by GlaxoSmithKline.
NCT02751320 is a NA study of Dental Caries that has completed, run by GlaxoSmithKline. The registered enrollment target is 58 participants, below the 720-participant average among 30 other Dental Caries trials with a reported enrollment target (92% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT02751320, a NA study of Dental Caries, has completed, sponsored by GlaxoSmithKline.
- COMPLETED
- Registry status
- NA
- Development phase
- 58 participants
- Enrollment target
- 1
- Study location
Study Summary
This will be a single-centre, randomized, blinded, placebo-controlled, 6-treatment, 4-period crossover, incomplete block design, in situ caries study in healthy adults who wear a removable bilateral mandibular partial denture. The denture will be modified to accommodate 4 gauze-covered specimens of human dental enamel (4x3mm) that have been previously demineralized in vitro to form either S or low-R lesions (2 specimens of each lesion type will be used with each participant). After 14 days of twice daily product use off-site, the 2 S lesion specimens will be removed at the study site, with the remaining 2 low-R lesion specimens removed at the study site after a further 14 days of product use. To determine the remineralization ability of the treatments, all specimens will be analyzed by transverse microradiography (TMR) and enamel fluoride uptake (EFU), with the S lesions additionally analyzed by surface micro hardness (SMH) and the low-R lesions additionally analyzed by quantitative light fluorescence (QLF).
Primary Outcome
SMHR test was used to assess the changes in mineralization status of partially demineralized enamel specimens using a Wilson 2100 Hardness tester. SMH was determined by measuring the length of the indentations of enamel specimens. % SMHR was calculated from indentation length (micrometer \[μm\]) of sound enamel specimen at baseline (B), indentation length (μm) after in vitro demineralization(D), indentation length (μm) after intra-oral exposure (R): \[D-R/D-B\]\*100.
Conditions Studied
Interventions
- DRUG 0.425 % w/w phytate,1150ppm F
- DRUG 0.85 % w/w phytate,1150ppm F
- DRUG 0.85 % w/w phytate,0.3%ZnCl2 0.5% sodium citrate, 1150ppm F
- OTHER 0 ppm F
- DRUG 1150ppm F
Study Locations (1)
Indiana
- GSK Investigational Site - Indianapolis
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 58 participants |
| Start Date | 2016-02-01 |
| Est. Completion | 2016-08-11 |
| Phase | NA |
What the finished NCT02751320 record still lists
NCT02751320 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 58 participants, a relatively small participant target, below the 720-participant average among 30 other Dental Caries trials with a reported enrollment target (92% lower).
The record links to 1 condition, with Dental Caries appearing as the primary indexed condition, and to 5 interventions - of which 0.425 % w/w phytate,1150ppm F is the first listed.
NCT02751320 reports a single indexed study location in Indiana.
Frequently Asked Questions
What is clinical trial NCT02751320 about?
NCT02751320 is a clinical study titled "Efficacy of Three Toothpastes Using an in Situ Caries Model". This will be a single-centre, randomized, blinded, placebo-controlled, 6-treatment, 4-period crossover, incomplete block design, in situ caries study in healthy adults who wear a removable bilateral mandibular partial denture. The denture will be modified to accommodate 4 gauze-covered specimens of ...
What is the current status of trial NCT02751320?
This trial is currently completed. It is a NA study. The enrollment target is 58 participants. The study started on 2016-02-01. Estimated completion is 2016-08-11.
What conditions does trial NCT02751320 study?
This clinical trial studies the following conditions: Dental Caries.
What interventions are being tested in trial NCT02751320?
The interventions under investigation include: 0.425 % w/w phytate,1150ppm F (DRUG), 0.85 % w/w phytate,1150ppm F (DRUG), 0.85 % w/w phytate,0.3%ZnCl2 0.5% sodium citrate, 1150ppm F (DRUG), 0 ppm F (OTHER), 1150ppm F (DRUG).
Who is sponsoring clinical trial NCT02751320?
This trial is sponsored by GlaxoSmithKline, which has 1,345 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT02751320 being conducted?
This trial has 1 study location across Indiana. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Dental Caries
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT02751320's enrollment target sits among peer trials
58 15th of 30 higher than 16 of 30 other Dental Caries trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Dental Caries trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
-
Comparing Stainless Steel Crowns with Prefabricated Resin Crowns in Primary Molar Teeth
RECRUITING · NA
-
LT Comparative Effectiveness of 2 Caries Treatments
RECRUITING · NA
-
Advancing Water Security: A Community Participatory School-Based Hydration Intervention
RECRUITING · NA
-
Oral Health Intervention in Adult Primary Care
RECRUITING · NA
-
Polymer Induced Liquid Precursor (PILP) in Adults in With Dentin Caries
RECRUITING · NA
-
In-situ Clinical Trial Assessing Ability to Detect and Monitor Active Caries and Their Remineralization
ACTIVE NOT RECRUITING · NA
Nationwide trials with similar profiles
Cross-condition peers matched on enrollment target and registry start date, not the same-condition list above.
Similar enrollment target
- NCT03587844 · 58 participants · Phase 2
Dosing of Brentuximab Vedotin for Mycosis Fungoides, Sezary Syndrome Patients
- NCT03630991 · 58 participants · Phase 1
Edetate Calcium Disodium or Succimer in Treating Patients With Acute Myeloid Leukemia or Myelodysplastic Syndrome Undergoing Chemotherapy
- NCT03949855 · 58 participants · Phase 2
Belimumab With Rituximab for Primary Membranous Nephropathy
- NCT04069273 · 58 participants · Phase 2
Novel SEQUEnced Immunotherapy With Anti-angiogenesis and Chemotherapy in Advanced gastroesophageaL Adenocarcinoma
Similar registry start date
- NCT05962346 · started 2026-12 · NA
Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia
- NCT07125183 · started 2026-12 · Phase 2
Study on Efficacy and Tolerability of Weekly Doxorubicin in Elderly Patients With Advanced or Metastatic Leiomyosarcoma
- NCT07292298 · started 2026-11 · Phase 2
Phase 2 Single-Arm Rectal Cancer Brachytherapy for Patients With Low-Lying Residual Adenocarcinoma After Total Neoadjuvant Therapy to Improve Organ Preservation Rates
- NCT04263285 · started 2026-10 · NA
Treatment of Depression Post-SCI