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ClinicalTrials.gov 24 recruiting now official registry

Delirium clinical trials

24 of 63 indexed Delirium trials are currently recruiting.

63 US clinical trials · 24 currently recruiting

Delirium is the subject of 63 registered US clinical trials on ClinicalTrials.gov, 24 of them currently open to new participants. 9 are in Phase 3-4 (later-stage) and 10 in Phase 1-2 (earlier-stage). The most active sponsor is Vanderbilt University Medical Center, running 5 of these trials.

The research picture

Delirium has 63 registered US clinical trials, 24 of them open to new participants right now, about 38% of the total.

24
recruiting participants now
38%
of trials open to enrollment
9
in Phase 3–4 (later-stage)
5
top sponsor: Vanderbilt University Medical Center
Phase 12Phase 28Phase 36Phase 43

Active & Recent Trials

63 total, page 1 of 2

RECRUITING NA 10,890 participants

Modifying the Inpatient Environment to Reduce Delirium in Older Adults

Farhaan S. Vahidy

NCT06736951

RECRUITING NA 8,100 participants

Behavioral Economic & Staffing Strategies in the ICU

University of Nebraska

NCT06184945

RECRUITING NA 3,000 participants

Evaluating Novel Healthcare Approaches to Nurturing and Caring for Hospitalized Elders

University of Michigan

NCT05929703

RECRUITING Phase 3 1,800 participants

Minimizing ICU Neurological Dysfunction With Dexmedetomidine-induced Sleep (MINDDS II)

Massachusetts General Hospital

NCT06192615

RECRUITING NA 1,050 participants

Researching Efficient Approaches to Delirium Identification-Sustaining Effective Translation

Penn State University

NCT05915377

RECRUITING NA 842 participants

CTSN Embolic Protection Trial

Icahn School of Medicine at Mount Sinai

NCT06027788

RECRUITING NA 528 participants

Delirium and Neuropsychological Recovery Among Emergency General Surgery Survivors

University of Wisconsin, Madison

NCT05373017

RECRUITING Phase 4 506 participants

Delirium Reduction With Ramelteon

Centennial Medical Center

NCT05069428

RECRUITING 468 participants

Interventions for Postoperative Delirium: Biomarker-3

University of Wisconsin, Madison

NCT03124303

RECRUITING 400 participants

Automating Delirium Severity in the ICU

Mayo Clinic

NCT06172491

RECRUITING 400 participants

Pervasive Sensing and AI in Intelligent ICU

University of Florida

NCT05127265

RECRUITING Phase 3 372 participants

Goal-Directed Sedation in Mechanically Ventilated Infants and Children

Vanderbilt University Medical Center

NCT04801589

RECRUITING 200 participants

Ceribell Delirium Data Collection Study

Ceribell

NCT04962815

RECRUITING NA 100 participants

Neurosteer Bedside Monitoring System

Icahn School of Medicine at Mount Sinai

NCT06718764

RECRUITING NA 100 participants

A Multi-Modal Combination Intervention to Promote Cognitive Function in Older Intensive Care Unit Survivors

University of Washington

NCT06411561

RECRUITING 60 participants

Trazodone vs. Quetiapine for the Treatment of ICU Delirium

University of Southern California

NCT05307003

RECRUITING 60 participants

Delirium Identification in Older Patients With Alzheimer's and Other Related Dementias In the Emergency Department

Ohio State University

NCT06326424

RECRUITING Early Phase 1 50 participants

Regional Nerve Blocks to Improve Analgesia and Recovery in Older Adults Undergoing Spinal Fusion

University of Iowa

NCT05461092

RECRUITING NA 50 participants

Simultaneous Recumbent Cycling and Cognitive Training

University of Missouri, Kansas City

NCT04556227

RECRUITING Phase 3 46 participants

Mitigating Delirium With Fluvoxamine Treatment for Non-Cardiac Surgery

Washington University School of Medicine

NCT06969287

RECRUITING Phase 2 42 participants

Managing Agitated Delirium With Neuroleptics and Anti-Epileptics as a Neuroleptic Sparing Strategy

M.D. Anderson Cancer Center

NCT05431595

RECRUITING NA 30 participants

Delirium in Neurodegenerative Disease Patients: A Music Therapy Intervention for Hospital Care

Boston Medical Center

NCT07137949

RECRUITING NA 15 participants

VoiceLove Digital Therapy for Delirium in the ICU

The Methodist Hospital Research Institute

NCT07218484

RECRUITING NA 10 participants

TaVNS for Delirium

Stony Brook University

NCT07258082

ACTIVE NOT RECRUITING NA 15,886 participants

Benzodiazepine-free Cardiac Anesthesia for Reduction of Postoperative Delirium

Population Health Research Institute

NCT03928236

ACTIVE NOT RECRUITING 1,040 participants

Delirium in Children Undergoing Stem Cell Transplantation

Weill Medical College of Cornell University

NCT04937400

ACTIVE NOT RECRUITING Phase 3 900 participants

PANDORA: Delirium Prevention After Cardiac Surgery Using IV Acetaminophen to Prevent Postoperative Delirium in Older Cardiac Surgical Patients

Beth Israel Deaconess Medical Center

NCT04093219

ACTIVE NOT RECRUITING 826 participants

The BRAIN Intensive Care Unit (ICU) Study: Bringing to Light the Risk Factors

Vanderbilt University Medical Center

NCT00392795

ACTIVE NOT RECRUITING 800 participants

Vasopressor SAT Study

University of Chicago

NCT03182335

ACTIVE NOT RECRUITING 432 participants

Illuminating Neuropsychological Dysfunction and Systemic Inflammatory Mechanisms Gleaned After Hospitalization in Trauma-ICU Study

Vanderbilt University Medical Center

NCT03098459

ACTIVE NOT RECRUITING 130 participants

Intelligent Intensive Care Unit

University of Florida

NCT02465307

ACTIVE NOT RECRUITING NA 120 participants

SLeep and OPioid UsE in Patients Undergoing Total Knee Arthroplasty

Scripps Health

NCT04247646

ACTIVE NOT RECRUITING Phase 2 110 participants

Haloperidol and Lorazepam in Controlling Symptoms of Persistent Agitated Delirium in Patients With Advanced Cancer Undergoing Palliative Care

M.D. Anderson Cancer Center

NCT03743649

ACTIVE NOT RECRUITING NA 100 participants

Digital Rehabilitation Environment Augmenting Medical System

University of Florida

NCT03385993

ACTIVE NOT RECRUITING 71 participants

Fundamental Intelligent Building Blocks of the Intensive Care Unit (ICU) of the Future: Intelligent ICU of the Future

University of Florida

NCT03905668

ACTIVE NOT RECRUITING Phase 2 70 participants

Haloperidol With or Without Chlorpromazine in Treating Delirium in Patients With Advanced, Metastatic, or Recurrent Cancer

M.D. Anderson Cancer Center

NCT03021486

ACTIVE NOT RECRUITING 24 participants

Driving Rehabilitation and Innovation for Evaluating Risk in Post-Intensive Care Unit Survivors

Baylor Research Institute

NCT05999903

COMPLETED 800 participants

MIND-ICU Study: Delirium and Dementia in Veterans Surviving ICU Care

VA Office of Research and Development

NCT00400062

COMPLETED Phase 3 566 participants

The Modifying the Impact of ICU-Associated Neurological Dysfunction-USA (MIND-USA) Study

Vanderbilt University Medical Center

NCT01211522

COMPLETED Phase 2 522 participants

Investigation of Sleep in the Intensive Care Unit

Massachusetts General Hospital

NCT03355053

COMPLETED Phase 3 438 participants

The MENDS2 Study, Maximizing the Efficacy of Sedation and Reducing Neurological Dysfunction and Mortality in Septic Patients With Acute Respiratory Failure

Vanderbilt University Medical Center

NCT01739933

COMPLETED NA 424 participants

e-CHAMP: Enhancing Care for Hospitalized Older Adults With Memory Problems

Indiana University

NCT00182832

COMPLETED NA 373 participants

Implementation of Multidisciplinary Assessments for Geriatric Patients in an ED Observation Unit

Ohio State University

NCT04068311

COMPLETED Phase 2 301 participants

Care.Coach Avatars for Improvement of Outcomes in Hospitalized Elders, Including Mitigation of Falls and Delirium: a Multi-Site Clinical Study

Victor Wang

NCT03832192

COMPLETED NA 249 participants

Improving the Recovery and Outcome Every Day After the ICU

Indiana University

NCT03095417

COMPLETED NA 219 participants

Nursing Assistant Intervention to Prevent Delirium in Nursing Homes

Jewish Home & Hospital Lifecare System

NCT02994979

COMPLETED NA 218 participants

Shaping Anesthetic Techniques to Reduce Post-operative Delirium

Johns Hopkins University

NCT03133845

COMPLETED NA 205 participants

Anesthetic Depth and Postoperative Delirium Trial - 2

University of California, San Francisco

NCT01983384

COMPLETED NA 200 participants

Post-Operative Delirium in Elderly Surgical Patients

Johns Hopkins University

NCT00590707

COMPLETED Phase 4 135 participants

Preventing Post-Operative Delirium in Patients Undergoing a Pneumonectomy, Esophagectomy or Thoracotomy

Indiana University

NCT02213900

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Phase Distribution

PhaseTrial count
Phase 1 2
Phase 2 8
Phase 3 6
Phase 4 3

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Delirium Trial Landscape

63 indexed Delirium studies · 24 recruiting (38%).

Phase mix: 9 late (III/IV) vs 10 early (I/II).

Top sponsor: Vanderbilt University Medical Center (5 trials), 9 others listed. 50 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Delirium?

PlainTrial tracks 63 US clinical trials for Delirium, of which 24 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Delirium?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.