Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.

2026 data Public-data reference. official source

Pancreatic Adenocarcinoma

Open-data reference.

63 US clinical trials · 31 currently recruiting

Active & Recent Trials

RECRUITING 20,000 participants

Collecting Medical Information and Tissue Samples From Patients With Pancreatic Cancer or Other Pancreatic Disorders

Mayo Clinic

NCT00830557

RECRUITING 2,020 participants

ORACLE: Observation of ResiduAl Cancer With Liquid Biopsy Evaluation

Guardant Health

NCT05059444

RECRUITING 2,000 participants

Pancreatic Cancer Detection Consortium

City of Hope Medical Center

NCT06388967

RECRUITING Phase 1 949 participants

A Study of BMS-986340 as Monotherapy and in Combination With Nivolumab or Docetaxel in Participants With Advanced Solid Tumors

Bristol-Myers Squibb

NCT04895709

RECRUITING NA 845 participants

High Volume Washing of the Abdomen in Increasing Survival After Surgery in Patients With Pancreatic Cancer That Can Be Removed by Surgery

Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University

NCT02757859

RECRUITING Phase 1 714 participants

A Study of PF-08046054/SGN-PDL1V in Advanced Solid Tumors

Seagen, a wholly owned subsidiary of Pfizer

NCT05208762

RECRUITING NA 590 participants

Association Between Health Care Provider (HCP)-Assessed ECOG Performance Status (PS) and Overall Survival, and Objectively Measure of Physical Activity (PA) Levels in Advance-cancer Patients"

M.D. Anderson Cancer Center

NCT01365169

RECRUITING Phase 1 574 participants

Study of RMC-5127 in Patients With Advanced KRAS G12V-Mutant Solid Tumors

Revolution Medicines

NCT07349537

RECRUITING Phase 1 398 participants

A Study of ASP2138 Given by Itself or Given With Other Cancer Treatments in Adults With Stomach Cancer, Gastroesophageal Junction Cancer, or Pancreatic Cancer

Astellas Pharma Global Development

NCT05365581

RECRUITING Phase 1 336 participants

Phase 1 Study of MRTX1719 in Solid Tumors With MTAP Deletion

Bristol-Myers Squibb

NCT05245500

RECRUITING Phase 1 230 participants

Study to Assess GTAEXS617 in Participants With Advanced Solid Tumors

Exscientia AI Ltd., a wholly owned subsidiary of Recursion Pharmaceuticals

NCT05985655

RECRUITING Phase 1 175 participants

Study of LP-184 in Patients With Advanced Solid Tumors

Lantern Pharma

NCT05933265

RECRUITING Phase 1 166 participants

A Phase 1, First-in-human Study of OKN4395 and Pembrolizumab in Patients With Solid Tumors

Epkin

NCT06789172

RECRUITING Phase 1 104 participants

Basal-like PDAC Treated With Gemcitabine, Erlotinib, and Nab-paclitaxel

UNC Lineberger Comprehensive Cancer Center

NCT06483555

RECRUITING 100 participants

Small Intestinal Bacterial Overgrowth (SIBO) in Pancreatic Adenocarcinoma (PDAC)

Cedars-Sinai Medical Center

NCT06988150

RECRUITING Phase 1 100 participants

A Study to Investigate APL-5125 in Adults With Advanced Solid Tumors

Apollo Therapeutics

NCT06399757

RECRUITING Phase 1 90 participants

A Study of CLSP-1025 in Adult Patients With Solid Tumors That Harbor the p53 R175H Mutation

Clasp Therapeutics

NCT06778863

RECRUITING Phase 2 66 participants

Multicenter Trial of ESK981 in Patients With Select Solid Tumors

University of Michigan Rogel Cancer Center

NCT05988918

RECRUITING Phase 1 54 participants

Safety of Combining Irinotecan With 5-FU, Leucovorin/Folinic Acid, Oxaliplatin, and Docetaxel Chemotherapies

University of Chicago

NCT04361708

RECRUITING Phase 1 46 participants

A Study of NT-175 in Adult Subjects With Unresectable, Advanced, and/or Metastatic Solid Tumors That Are Positive for HLA-A*02:01 and the TP53 R175H Mutation

AstraZeneca

NCT05877599

RECRUITING Phase 1 45 participants

Binary Oncolytic Adenovirus in Combination With HER2-Specific Autologous CAR VST, Advanced HER2 Positive Solid Tumors

Baylor College of Medicine

NCT03740256

RECRUITING Phase 1 40 participants

Nab-Paclitaxel + Cisplatin + Gemcitabine + TTF in pt. w/ Metastatic PAC

Mayo Clinic

NCT04605913

RECRUITING Phase 2 38 participants

A Study of NovoTTF-200T(P) in Combination With Gemcitabine and Nab-Paclitaxel for Resectable Pancreatic Adenocarcinoma

Ashish Manne

NCT05624918

RECRUITING NA 30 participants

Alpha Radiation Emitters Device for the Treatment of Pancreatic Cancer With Chemotherapy for the Treatment of Locally Advanced and Metastatic Pancreatic Cancer

Alpha Tau Medical

NCT06698458

RECRUITING Phase 1 27 participants

Panitumumab-IRDye800 in Patients With Pancreatic Cancer Undergoing Surgery

George Poultsides

NCT03384238

RECRUITING Phase 2 24 participants

Chemotherapy + Anakinra in Patients With Pancreatic Adenocarcinoma (PDAC)

Baylor Research Institute

NCT04926467

RECRUITING Phase 1 22 participants

Prehabilitation for EOC, Fallopian Tube, Primary Peritoneal Carcinoma and Pancreatic Cancer w/ NACT

Case Comprehensive Cancer Center

NCT06412510

RECRUITING Phase 3 20 participants

Evaluating Novel Therapies in ctDNA Positive GI Cancers

Georgetown University

NCT05482516

RECRUITING Phase 1 18 participants

Th-1 Dendritic Cell Immunotherapy Plus Standard Chemotherapy for Pancreatic Adenocarcinoma

Diakonos Oncology Corporation

NCT04157127

RECRUITING Phase 1 12 participants

9-ING-41 Combined With Retifanlimab, Plus Modified FOLFIRINOX for Patients With Advanced Pancreatic Adenocarcinoma (RiLEY)

Anwaar Saeed

NCT06896188

RECRUITING Phase 2 10 participants

Immunotherapy and Irreversible Electroporation in the Treatment of Advanced Pancreatic Adenocarcinoma

University of Louisville

NCT03080974

ACTIVE NOT RECRUITING 6,134,060 participants

Prospective Validation of an EHR-based Pancreatic Cancer Risk Model

Beth Israel Deaconess Medical Center

NCT05973331

ACTIVE NOT RECRUITING Phase 2 350 participants

9-ING-41 in Patients with Advanced Cancers

Actuate Therapeutics

NCT03678883

ACTIVE NOT RECRUITING 300 participants

Pancreatic Cancer Biomarker Study

Van Andel Research Institute

NCT04143152

ACTIVE NOT RECRUITING Phase 1 209 participants

A Phase 1/2a Study of IMM-1-104 in Participants With Advanced or Metastatic Solid Tumors

Immuneering Corporation

NCT05585320

ACTIVE NOT RECRUITING Phase 1 120 participants

Study of DECOY20 With or Without Tislelizumab in Patients With Advanced Solid Tumors

Indaptus Therapeutics

NCT05651022

ACTIVE NOT RECRUITING 100 participants

Pancreatic Cancer Early Detection Program

White Plains Hospital

NCT02206360

ACTIVE NOT RECRUITING 74 participants

Predicting Effective Therapy in Pancreatic Cancer

Memorial Sloan Kettering Cancer Center

NCT03033927

ACTIVE NOT RECRUITING Phase 1 74 participants

Testing the Combination of Anetumab Ravtansine With Either Nivolumab, Nivolumab and Ipilimumab, or Gemcitabine and Nivolumab in Advanced Pancreatic Cancer

National Cancer Institute (NCI)

NCT03816358

ACTIVE NOT RECRUITING Phase 2 70 participants

FOLFIRINOX + Elraglusib + Losartan In Pancreatic Cancer

Colin D. Weekes, M.D., PhD

NCT05077800

ACTIVE NOT RECRUITING Phase 1 61 participants

Recombinant EphB4-HSA Fusion Protein With Standard Chemotherapy Regimens in Treating Patients With Advanced or Metastatic Solid Tumors

University of Southern California

NCT02495896

ACTIVE NOT RECRUITING Phase 2 46 participants

Hypofractionated Stereotactic Body Radiation & Fluorouracil or Capecitabine for Locally Advanced Pancreatic Cancer

University of Nebraska

NCT03073785

ACTIVE NOT RECRUITING Phase 2 45 participants

A Study of the Safety and Activity of Liposomal Irinotecan in Combination With the 5-FU and Oxaliplatin in the Preoperative Treatment of Pancreatic Adenocarcinoma

University of Florida

NCT03483038

ACTIVE NOT RECRUITING Phase 2 42 participants

NeoOPTIMIZE: Early Switching of mFOLFIRINOX or Gemcitabine/Nab-Paclitaxel Before Surgery for the Treatment of Resectable, Borderline Resectable, or Locally-Advanced Unresectable Pancreatic Cancer

OHSU Knight Cancer Institute

NCT04539808

ACTIVE NOT RECRUITING Phase 2 36 participants

Pancreaze (Pancrelipase) for Patients With Pancreatic Adenocarcinoma With Cachexia and Exocrine Pancreatic Insufficiency

Andrew Hendifar, MD

NCT04098237

ACTIVE NOT RECRUITING NA 25 participants

Resistance Training Intervention to Improve Physical Function in Patients With Pancreatic Cancer Receiving Combination Chemotherapy or Have Undergone Surgery, PancStrength Study

M.D. Anderson Cancer Center

NCT04837118

ACTIVE NOT RECRUITING Phase 2 24 participants

Pre-operative Treatment for Patients With Untreated Pancreatic Cancer

HonorHealth Research Institute

NCT03138720

ACTIVE NOT RECRUITING Phase 1 21 participants

Gemcitabine Hydrochloride, Paclitaxel Albumin-Stabilized Nanoparticle Formulation, Metformin Hydrochloride, and a Standardized Dietary Supplement in Treating Patients With Pancreatic Cancer That Cannot be Removed by Surgery

City of Hope Medical Center

NCT02336087

ACTIVE NOT RECRUITING Phase 1 19 participants

A Study of SGN-MesoC2 in Advanced Solid Tumors

Seagen, a wholly owned subsidiary of Pfizer

NCT06466187

ACTIVE NOT RECRUITING Phase 1 18 participants

Radiation Therapy in Combination With Durvalumab for People With Pancreatic Cancer

Memorial Sloan Kettering Cancer Center

NCT03245541

ACTIVE NOT RECRUITING Phase 2 14 participants

Hepatic Artery Infusional Floxuridine to Treat Pancreatic Cancer Liver Metastases

Corewell Health West

NCT03856658

ACTIVE NOT RECRUITING Phase 2 10 participants

The PLATINUM Trial: Optimizing Chemotherapy for the Second-Line Treatment of Metastatic BRCA1/2 or PALB2-Associated Metastatic Pancreatic Cancer

Alliance for Clinical Trials in Oncology

NCT06115499

ACTIVE NOT RECRUITING Phase 1 7 participants

A Study of Armed, Activated T-Cells in Patients With Advanced Pancreatic Cancer

Memorial Sloan Kettering Cancer Center

NCT04137536

ACTIVE NOT RECRUITING Phase 1 6 participants

A Phase 1/2 Trial of TC-510 In Patients With Advanced Mesothelin-Expressing Cancer

TCR2 Therapeutics

NCT05451849

COMPLETED NA 445 participants

Spectroscopy From Duodenum

Olympus Corporation

NCT01753479

COMPLETED 397 participants

Assessment of What Patients and Healthcare Providers Value

M.D. Anderson Cancer Center

NCT04483349

COMPLETED Phase 2 112 participants

Study of Nab-Paclitaxel and Gemcitabine and Plus/Minus VCN-01 in Patients With Metastatic Pancreatic Cancer

Theriva Biologics SL

NCT05673811

COMPLETED Phase 1 105 participants

Safety Study of Imexon Plus Gemcitabine in Untreated Pancreatic Adenocarcinoma

AmpliMed Corporation

NCT00327327

COMPLETED 83 participants

Feasibility of Obtaining and Characterizing Circulating Tumorigenic Cells in Patients With Pancreatic Adenocarcinoma

Memorial Sloan Kettering Cancer Center

NCT01474564

COMPLETED Phase 2 48 participants

Perioperative Therapy for Resectable and Borderline-Resectable Pancreatic Adenocarcinoma With Molecular Correlates

Academic Thoracic Oncology Medical Investigators Consortium

NCT02723331

COMPLETED Phase 1 30 participants

3-AP and Radiation Therapy in Treating Patients With Stage III Pancreatic Cancer That Cannot Be Removed By Surgery

National Cancer Institute (NCI)

NCT00288093

COMPLETED NA 28 participants

Trial Comparing EUS-guided Radiofrequency Ablation vs. EUS-guided Celiac Plexus Neurolysis

AdventHealth

NCT03152487

COMPLETED Phase 1 19 participants

A Safety and Efficacy Study Evaluating CTX131 in Adult Subjects With Relapsed or Refractory Solid Tumors

CRISPR Therapeutics

NCT05795595

Phase Distribution

PhaseTrial count
Early Phase 1 31
Phase 2 15
Phase 3 1

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Pancreatic Adenocarcinoma Trial Landscape

ClinicalTrials.gov lists 63 US studies indexed under Pancreatic Adenocarcinoma, and 31 of those are currently open to recruitment — roughly 49% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

The phase distribution for Pancreatic Adenocarcinoma shows 1 late-stage studies (Phase 3 and Phase 4 combined) alongside 46 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

Top sponsor activity for Pancreatic Adenocarcinoma is led by Memorial Sloan Kettering Cancer Center with 4 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 63 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Pancreatic Adenocarcinoma?

PlainTrial tracks 63 US clinical trials for Pancreatic Adenocarcinoma, of which 31 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Pancreatic Adenocarcinoma?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2024 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

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