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NCT05307003 · ClinicalTrials.gov registry record

Trazodone vs. Quetiapine for the Treatment of ICU Delirium

A clinical trial of Delirium and Delirium in Old Age, sponsored by University of Southern California.

Recruiting
Registry status
60
Enrollment target
1
Study location

NCT05307003: Recruiting study of Delirium and Delirium in Old Age, sponsored by University of Southern California.

NCT05307003 is a study of Delirium and Delirium in Old Age that is actively recruiting participants, run by University of Southern California. The registered enrollment target is 60 participants, below the 887-participant average among 62 other Delirium trials with a reported enrollment target (93% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.

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The verdict

NCT05307003, a study of Delirium and Delirium in Old Age, is actively recruiting participants, sponsored by University of Southern California.

RECRUITING
Registry status
60 participants
Enrollment target
1
Study location

Study Summary

This is a single-center, prospective observational pilot study. The objective of this study is to evaluate the effectiveness of trazodone as compared to quetiapine, in the management of ICU delirium in adult (\>=18 years old) surgical and medical ICU patients. The investigators will compare outcomes such as delirium duration, delirium-free days, coma-free days, in-hospital mortality, 28-day mortality, hospital length of stay (LOS), ICU LOS, mechanical ventilator days, complications, adverse effects, rescue medication use, delirium symptom severity, sleep duration, and sleep quality among participants receiving trazodone or quetiapine. The investigators hypothesize participants receiving trazodone will be associated with a shorter duration of delirium, decreased delirium severity, and improved sleep quality compared to participants receiving quetiapine.

Primary Outcome

days

Conditions Studied

Delirium Delirium in Old Age Morality Treatment Side Effects Delirium, Sepsis Associated Delirium Confusional State Delirium of Mixed Origin Psych

Interventions

  • DRUG Trazodone
  • DRUG Quetiapine

Study Locations (1)

California

  • Keck Hospital of the University of Southern California - Los Angeles

Trial Details

FieldValue
Enrollment Target 60 participants
Start Date 2023-04-01
Est. Completion 2025-12
University of Southern California

617 total trials

What NCT05307003 shows while recruiting

NCT05307003 is an observational study that tracks outcomes without assigning an intervention. The registry caps enrollment at 60 participants, a relatively small participant target, below the 887-participant average among 62 other Delirium trials with a reported enrollment target (93% lower).

The record links to 8 conditions, with Delirium appearing as the primary indexed condition, and to 2 interventions - of which Trazodone is the first listed.

NCT05307003 reports a single indexed study location in California.

Frequently Asked Questions

What is clinical trial NCT05307003 about?

NCT05307003 is a clinical study titled "Trazodone vs. Quetiapine for the Treatment of ICU Delirium". This is a single-center, prospective observational pilot study. The objective of this study is to evaluate the effectiveness of trazodone as compared to quetiapine, in the management of ICU delirium in adult (\>=18 years old) surgical and medical ICU patients. The investigators will compare outcomes...

What is the current status of trial NCT05307003?

This trial is currently recruiting. The enrollment target is 60 participants. The study started on 2023-04-01. Estimated completion is 2025-12.

What conditions does trial NCT05307003 study?

This clinical trial studies the following conditions: Delirium, Delirium in Old Age, Morality, Treatment Side Effects, Delirium, Sepsis Associated.

What interventions are being tested in trial NCT05307003?

The interventions under investigation include: Trazodone (DRUG), Quetiapine (DRUG).

Who is sponsoring clinical trial NCT05307003?

This trial is sponsored by University of Southern California, which has 617 total clinical trials registered on ClinicalTrials.gov.

Where is trial NCT05307003 being conducted?

This trial has 1 study location across California. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Learn More About Clinical Trials

Similar trials for Delirium

Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.

Where NCT05307003's enrollment target sits among peer trials

60 46th of 62 higher than 16 of 62 other Delirium trials

participants (enrollment target), bucketed by value

Each bar is a band; taller bars hold more other Delirium trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.

Source ClinicalTrials.gov registry export · 2026-08-08

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More recruiting context for NCT05307003

Source: ClinicalTrials.gov NCT05307003, the US trial registry maintained by the National Library of Medicine. NCT05307003 (small enrollment · single site footprint · recruiting) retrieved and formatted by PlainTrial, see methodology.