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NCT05638932 · ClinicalTrials.gov registry record
Methodologies for Observational Studies Comparing Inpatient COVID-19 Treatments
A clinical trial of COVID-19, sponsored by Aetion.
- Completed
- Registry status
- 1,442
- Enrollment target
- 1
- Study location
NCT05638932: Completed study of COVID-19, sponsored by Aetion.
NCT05638932 is a study of COVID-19 that has completed, run by Aetion. The registered enrollment target is 1,442 participants, below the 38,460-participant average among 298 other COVID-19 trials with a reported enrollment target (96% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05638932, a study of COVID-19, has completed, sponsored by Aetion.
- COMPLETED
- Registry status
- 1,442 participants
- Enrollment target
- 1
- Study location
Study Summary
To apply and compare two different methodological approaches (one applying diagnostics steps and contingencies and the other not) to the illustrative example described below: Illustrative Example - Objective I aims to characterize the risk of inpatient mortality \[Primary Outcome\] and progression to invasive mechanical ventilation (IMV) or extracorporeal membrane oxygenation (ECMO) \[Secondary Outcome\] up to 28 days after interleukin-6 receptor inhibitors (IL6Ri) or janus kinase inhibitor (JAKi) initiation among patients hospitalized with Coronavirus Disease 2019 (COVID-19) who initiate a corticosteroid of interest and require supplemental oxygen / non-invasive ventilation / high flow oxygen (O2/NIV/HFO) (but not IMV/ECMO). Illustrative Example - Objective II aims to characterize the risk of inpatient mortality \[Primary Outcome\] up to 28 days after IL6Ri or JAKi initiation among patients admitted to the ICU at hospital admission with COVID-19 who initiate a CSI and require IMV/ECMO. Hazard ratios (HR) and corresponding 95% confidence intervals (CI) will be estimated and reported for all outcome risks in Illustrative Example objectives.
Primary Outcome
Inpatient mortality up to 28 days after IL6Ri or JAKi initiation
Conditions Studied
Interventions
- DRUG Initiation of IL6Ri (tocilizumab or sarilumab) versus JAKi (baricitinib or tofacitinib) added to systemic corticosteroids of interest (CSI)
Study Locations (1)
New York
- Aetion, Inc. - New York
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 1,442 participants |
| Start Date | 2020-06-16 |
| Est. Completion | 2023-09-25 |
What the finished NCT05638932 record still lists
NCT05638932 is an observational study that tracks outcomes without assigning an intervention. Its 1,442 participants enrollment target places it among the larger protocols in the corpus, below the 38,460-participant average among 298 other COVID-19 trials with a reported enrollment target (96% lower).
The record links to 1 condition, with COVID-19 appearing as the primary indexed condition, and to 1 intervention - of which Initiation of IL6Ri (tocilizumab or sarilumab) versus JAKi (baricitinib or tofacitinib) added to systemic corticosteroids of interest (CSI) is the first listed.
NCT05638932 reports a single indexed study location in New York.
Frequently Asked Questions
What is clinical trial NCT05638932 about?
NCT05638932 is a clinical study titled "Methodologies for Observational Studies Comparing Inpatient COVID-19 Treatments". To apply and compare two different methodological approaches (one applying diagnostics steps and contingencies and the other not) to the illustrative example described below: Illustrative Example - Objective I aims to characterize the risk of inpatient mortality \[Primary Outcome\] and progression ...
What is the current status of trial NCT05638932?
This trial is currently completed. The enrollment target is 1,442 participants. The study started on 2020-06-16. Estimated completion is 2023-09-25.
What conditions does trial NCT05638932 study?
This clinical trial studies the following conditions: COVID-19.
What interventions are being tested in trial NCT05638932?
The interventions under investigation include: Initiation of IL6Ri (tocilizumab or sarilumab) versus JAKi (baricitinib or tofacitinib) added to systemic corticosteroids of interest (CSI) (DRUG).
Who is sponsoring clinical trial NCT05638932?
This trial is sponsored by Aetion, which has 3 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05638932 being conducted?
This trial has 1 study location across New York. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT05638932's enrollment target sits among peer trials
1,442 56th of 298 higher than 243 of 298 other COVID-19 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other COVID-19 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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