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NCT05780281 · ClinicalTrials.gov registry record · Phase 3
VIR-7831 for Inpatients With COVID-19 (An ACTIV-3/TICO Treatment Trial)
A Phase 3 study of COVID-19, sponsored by National Institute of Allergy and Infectious Diseases (NIAID).
- Completed
- Registry status
- Phase 3
- Development phase
- 367
- Enrollment target
- 20
- Study locations
NCT05780281: Completed Phase 3 study of COVID-19, sponsored by National Institute of Allergy and Infectious Diseases (NIAID).
NCT05780281 is a Phase 3 study of COVID-19 that has completed, run by National Institute of Allergy and Infectious Diseases (NIAID). The registered enrollment target is 367 participants, below the 38,464-participant average among 298 other COVID-19 trials with a reported enrollment target (99% lower). The trial reports 20 study locations across 5 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05780281, a Phase 3 study of COVID-19, has completed, sponsored by National Institute of Allergy and Infectious Diseases (NIAID).
- COMPLETED
- Registry status
- Phase 3
- Development phase
- 367 participants
- Enrollment target
- 20
- Study locations
Study Summary
This study looks at the safety and effectiveness of VIR-7831 in treating COVID-19 in people who have been hospitalized with the infection. Participants in the study will be treated with either VIR-7831 plus current standard of care (SOC), or with placebo plus current SOC. This is ACTIV-3/TICO Treatment Trial H2.
Primary Outcome
Sustained recovery defined as being discharged from the index hospitalization, followed by being alive and home for 14 consecutive days prior to Day 90.
Conditions Studied
Interventions
- BIOLOGICAL Placebo
- BIOLOGICAL Remdesivir
- BIOLOGICAL VIR-7831
Study Locations (20)
California
- Community Regional Medical Center (Site 203-005), 2823 Fresno Street - Fresno
- VA Loma Linda Healthcare System (Site 074-017), 11201 Benton Street - Loma Linda
- VA Long Beach Healthcare System (Site 074-026), 5901 East 7th Street (09/151-M2) - Long Beach
- Keck Hospital of USC (Site 301-020), 1500 San Pablo Street - Los Angeles
- Cedars-Sinai Medical Center (Site 208-002), 8700 Beverly Blvd. - Los Angeles
- Ronald Reagan UCLA Medical Center (Site 203-002), 757 Westwood Plaza - Los Angeles
- Hoag Memorial Hospital Presbyterian (Site 080-026), One Hoag Drive - Newport Beach
- UCSF Medical Center at Mount Zion (Site 203-007), 1600 Divisadero St. - San Francisco
- San Francisco VAMC (Site 074-002), 4150 Clement St. - San Francisco
- UCSF Medical Center (Site 203-001), Moffitt-Long Hospital, 505 Parnassus Ave. - San Francisco
- Stanford University Hospital & Clinics (Site 203-003), 300 Pasteur Dr. - Stanford
- Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center (Site 066-002), 1124 W. Carson Street, CDCRC Building - Torrance
Colorado
- University of Colorado Hospital (Site 204-001), 12605 E. 16th Avenue - Aurora
- Denver Public Health (Site 017-004), 660 Bannock St., MC2600 (Infectious Disease Clinic) - Denver
- National Jewish Health / St. Joseph Hospital (Site 204-003), 1400 Jackson Street - Denver
Arizona
- Banner University Medical Center Tucson (Site 206-004), 1625 N. Campbell Avenue - Tucson
- Southern Arizona VA Healthcare System (Site 074-009), 3601 S. 6th Ave. - Tucson
District of Columbia
- MedStar Georgetown University Hospital (Site 067-001), 3800 Reservoir Road NW - Washington D.C.
- Washington DC VA Medical Center (Site 009-004), 50 Irving Street NW - Washington D.C.
Florida
- Bay Pines VAMC (Site 074-004), 10000 Bay Pines Blvd., Bldg. 100, Room 5B-104 - Bay Pines
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 367 participants |
| Start Date | 2020-12-16 |
| Est. Completion | 2022-10-04 |
| Phase | Phase 3 |
What the finished NCT05780281 record still lists
NCT05780281 is an interventional study that assigns participants to a tested intervention. The registered 367 participants enrollment target is mid-sized for trials with a published cap, below the 38,464-participant average among 298 other COVID-19 trials with a reported enrollment target (99% lower).
The record links to 1 condition, with COVID-19 appearing as the primary indexed condition, and to 3 interventions - of which Placebo is the first listed.
NCT05780281 names 20 study sites across 5 states, led by California, Colorado, Arizona.
Frequently Asked Questions
What is clinical trial NCT05780281 about?
NCT05780281 is a clinical study titled "VIR-7831 for Inpatients With COVID-19 (An ACTIV-3/TICO Treatment Trial)". This study looks at the safety and effectiveness of VIR-7831 in treating COVID-19 in people who have been hospitalized with the infection. Participants in the study will be treated with either VIR-7831 plus current standard of care (SOC), or with placebo plus current SOC. This is ACTIV-3/TICO Treatm...
What is the current status of trial NCT05780281?
This trial is currently completed. It is a Phase 3 study. The enrollment target is 367 participants. The study started on 2020-12-16. Estimated completion is 2022-10-04.
What conditions does trial NCT05780281 study?
This clinical trial studies the following conditions: COVID-19.
What interventions are being tested in trial NCT05780281?
The interventions under investigation include: Placebo (BIOLOGICAL), Remdesivir (BIOLOGICAL), VIR-7831 (BIOLOGICAL).
Who is sponsoring clinical trial NCT05780281?
This trial is sponsored by National Institute of Allergy and Infectious Diseases (NIAID), which has 2,006 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05780281 being conducted?
This trial has 20 study locations across Arizona, California, Colorado, District of Columbia, Florida. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT05780281's enrollment target sits among peer trials
367 129th of 298 higher than 169 of 298 other COVID-19 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other COVID-19 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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