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NCT05780463 · ClinicalTrials.gov registry record · Phase 3
MP0420 for Inpatients With COVID-19 (An ACTIV-3/TICO Treatment Trial)
A Phase 3 study of COVID-19, sponsored by National Institute of Allergy and Infectious Diseases (NIAID).
- Completed
- Registry status
- Phase 3
- Development phase
- 485
- Enrollment target
- 20
- Study locations
NCT05780463: Completed Phase 3 study of COVID-19, sponsored by National Institute of Allergy and Infectious Diseases (NIAID).
NCT05780463 is a Phase 3 study of COVID-19 that has completed, run by National Institute of Allergy and Infectious Diseases (NIAID). The registered enrollment target is 485 participants, below the 38,463-participant average among 298 other COVID-19 trials with a reported enrollment target (99% lower). The trial reports 20 study locations across 4 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05780463, a Phase 3 study of COVID-19, has completed, sponsored by National Institute of Allergy and Infectious Diseases (NIAID).
- COMPLETED
- Registry status
- Phase 3
- Development phase
- 485 participants
- Enrollment target
- 20
- Study locations
Study Summary
This study looks at the safety and effectiveness of MP0420 in treating COVID-19 in people who have been hospitalized with the infection. Participants in the study will be treated with either MP0420 plus current standard of care (SOC), or with placebo plus current SOC. This is ACTIV-3/TICO Treatment Trial H5.
Primary Outcome
Sustained recovery defined as being discharged from the index hospitalization, followed by being alive and home for 14 consecutive days prior to Day 90.
Conditions Studied
Interventions
- DRUG Placebo
- DRUG MP0420
- BIOLOGICAL Remdesivir
Study Locations (20)
California
- Velocity Chula Vista (Site 080-034), 752 Medical Center Ct., Ste. 304 - Chula Vista
- Community Regional Medical Center (Site 203-005), 2823 Fresno Street - Fresno
- Velocity San Diego (Site 080-035), 5565 Grossmont Center Drive, Building 2, Suite 1 - La Mesa
- VA Long Beach Healthcare System (Site 074-026), 5901 East 7th Street (09/151-M2) - Long Beach
- Cedars-Sinai Medical Center (Site 208-002), 8700 Beverly Blvd. - Los Angeles
- Ronald Reagan UCLA Medical Center (Site 203-002), 757 Westwood Plaza - Los Angeles
- Sacramento VA Medical Center (Site 074-023), 10535 Hospital Way - Mather
- Hoag Memorial Hospital Presbyterian (Site 080-026), One Hoag Drive - Newport Beach
- UC Davis Health (Site 203-004), 2315 Stockton Blvd. - Sacramento
- VA San Diego Healthcare System (Site 074-016), 3350 La Jolla Village Drive - San Diego
- UCSF Medical Center at Mount Zion (Site 203-007), 1600 Divisadero St. - San Francisco
- San Francisco VAMC (Site 074-002), 4150 Clement St. - San Francisco
- UCSF Medical Center (Site 203-001), Moffitt-Long Hospital, 505 Parnassus Ave. - San Francisco
- Stanford University Hospital & Clinics (Site 203-003), 300 Pasteur Dr. - Stanford
- Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center (Site 066-002), 1124 W. Carson Street, CDCRC Building - Torrance
Arizona
- Banner University Medical Center Tucson (Site 206-004), 1625 N. Campbell Avenue - Tucson
- Southern Arizona VA Healthcare System (Site 074-009), 3601 S. 6th Ave. - Tucson
Colorado
- University of Colorado Hospital (Site 204-001), 12605 E. 16th Avenue - Aurora
- Denver Public Health (Site 017-004), 660 Bannock St., MC2600 (Infectious Disease Clinic) - Denver
Connecticut
- West Haven VA Medical Center (Site 025-007), 950 Campbell Avenue - West Haven
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 485 participants |
| Start Date | 2021-06-11 |
| Est. Completion | 2023-06-08 |
| Phase | Phase 3 |
What the finished NCT05780463 record still lists
NCT05780463 is an interventional study that assigns participants to a tested intervention. The registered 485 participants enrollment target is mid-sized for trials with a published cap, below the 38,463-participant average among 298 other COVID-19 trials with a reported enrollment target (99% lower).
The record links to 1 condition, with COVID-19 appearing as the primary indexed condition, and to 3 interventions - of which Placebo is the first listed.
NCT05780463 names 20 study sites across 4 states, led by California, Arizona, Colorado.
Frequently Asked Questions
What is clinical trial NCT05780463 about?
NCT05780463 is a clinical study titled "MP0420 for Inpatients With COVID-19 (An ACTIV-3/TICO Treatment Trial)". This study looks at the safety and effectiveness of MP0420 in treating COVID-19 in people who have been hospitalized with the infection. Participants in the study will be treated with either MP0420 plus current standard of care (SOC), or with placebo plus current SOC. This is ACTIV-3/TICO Treatment ...
What is the current status of trial NCT05780463?
This trial is currently completed. It is a Phase 3 study. The enrollment target is 485 participants. The study started on 2021-06-11. Estimated completion is 2023-06-08.
What conditions does trial NCT05780463 study?
This clinical trial studies the following conditions: COVID-19.
What interventions are being tested in trial NCT05780463?
The interventions under investigation include: Placebo (DRUG), MP0420 (DRUG), Remdesivir (BIOLOGICAL).
Who is sponsoring clinical trial NCT05780463?
This trial is sponsored by National Institute of Allergy and Infectious Diseases (NIAID), which has 2,006 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05780463 being conducted?
This trial has 20 study locations across Arizona, California, Colorado, Connecticut. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT05780463's enrollment target sits among peer trials
485 115th of 298 higher than 184 of 298 other COVID-19 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other COVID-19 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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