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A Study to Evaluate VXA-CoV2-3.3 COVID-19 Vaccine Against Currently Approved/Authorized mRNA COVID-19 Injectable Booster Vaccine in Adults Previously Immunized Against COVID-19 Infection
NCT06672055 · View on ClinicalTrials.gov ↗
Study Summary
The primary objective of the study is to determine the relative efficacy of the investigational oral severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) vaccine tablet VXA-CoV2-3.3 compared to a currently recommended vaccine for the prevention of symptomatic Coronavirus Disease 2019 (COVID-19). In order to represent a more recently circulating SARS-CoV-2 variant, the main study endpoints will now evaluate the VXA-CoV2-3.3 (KP.2 strain) vaccine, and not the VXA-CoV2-3.1 (XBB.1.5 strain) vaccine.
Interventions
- BIOLOGICAL COMIRNATY®
- BIOLOGICAL VXA-CoV2-3.1
- BIOLOGICAL VXA-CoV2-3.3
Study Locations (20)
California
- Elligo Health Research (BTC/ClinEdge) - Core Healthcare Group — Cerritos
- Velocity Clinical Research - Chula Vista (eStudySite - Chula Vista) — Chula Vista
- Avacare - Benchmark Research - SOCAL-Colton — Colton
- Altasciences Los Angeles (Formerly WCCT Global) — Cypress
- Ark Clinical Research - Fountain Valley, CA — Fountain Valley
- Velocity Clinical Research - San Diego (eStudySite - La Mesa) — La Mesa
- Ark Clinical Research - Long Beach, CA — Long Beach
- Velocity Clinical Research (National Research Institute) - Panorama City — Los Angeles
- Northern California Research — Sacramento
- Avacare - Benchmark Research - Sacramento — Sacramento
- Velocity Clinical Research - Gardena — Santa Ana
Arizona
- Avacare - Lenzmeier Family Medicine — Glendale
- Desert Clinical Research — Mesa
- Velocity Clinical Research - MedPharmics - Phoenix — Phoenix
- Foothills Research Center — Phoenix
- Avacare (CCT) - Fiel Family & Sports Medicine — Tempe
Alabama
- Pinnacle Research Group — Anniston
- Core Clinical Trials - Central Alabama Research LLC — Birmingham
- Coastal Clinical Research — Mobile
Arkansas
- Baptist Health Center for Clinical Research - Little Rock — Little Rock
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 10,400 participants |
| Start Date | 2024-10-08 |
| Est. Completion | 2026-11 |
| Phase | Phase 2 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT06672055
The ClinicalTrials.gov registry entry for NCT06672055 describes a study currently listed as active not recruiting. It is categorized as Phase 2, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 10,400 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Vaxart, which has 5 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 2 conditions, with COVID-19 appearing as the primary indexed condition, and to 3 interventions — of which COMIRNATY® is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT06672055 reports 20 study locations spanning 4 distinct geographic areas — top geographies include California, Arizona, Alabama. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT06672055 about?
NCT06672055 is a clinical study titled "A Study to Evaluate VXA-CoV2-3.3 COVID-19 Vaccine Against Currently Approved/Authorized mRNA COVID-19 Injectable Booster Vaccine in Adults Previously Immunized Against COVID-19 Infection". The primary objective of the study is to determine the relative efficacy of the investigational oral severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) vaccine tablet VXA-CoV2-3.3 compared to a currently recommended vaccine for the prevention of symptomatic Coronavirus Disease 2019 (COVID-1...
What is the current status of trial NCT06672055?
This trial is currently active not recruiting. It is a Phase 2 study. The enrollment target is 10,400 participants. The study started on 2024-10-08. Estimated completion is 2026-11.
What conditions does trial NCT06672055 study?
This clinical trial studies the following conditions: COVID-19, SARS-CoV2. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT06672055?
The interventions under investigation include: COMIRNATY® (BIOLOGICAL), VXA-CoV2-3.1 (BIOLOGICAL), VXA-CoV2-3.3 (BIOLOGICAL). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT06672055?
This trial is sponsored by Vaxart, which has 5 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT06672055 being conducted?
This trial has 20 study locations across Alabama, Arizona, Arkansas, California. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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