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NCT06810934 · ClinicalTrials.gov registry record · Phase 1
A Phase 1/2A, Randomized Study of a T Follicular Helper (TFH)-Targeting Genetic Vaccine Strategy Designed to Induce Broad, Durable Immune Responses
A Phase 1 study of COVID-19 and SARS CoV 2 Infection, sponsored by Kara Chew.
- Recruiting
- Registry status
- Phase 1
- Development phase
- 80
- Enrollment target
- 2
- Study locations
NCT06810934 is a Phase 1 study of COVID-19 and SARS CoV 2 Infection that is actively recruiting participants, run by Kara Chew. The registered enrollment target is 80 participants, below the 55,214-participant average among 203 other COVID-19 trials with a reported enrollment target (100% lower). The trial reports 2 study locations across 1 state.
The verdict
NCT06810934, a Phase 1 study of COVID-19 and SARS CoV 2 Infection, is actively recruiting participants, sponsored by Kara Chew.
- RECRUITING
- Registry status
- Phase 1
- Development phase
- 80 participants
- Enrollment target
- 2
- Study locations
Study Summary
The goal of this clinical trial is to test two investigational COVID-19 booster vaccines, called CoTend-s3BXBB and CoTend-BXBB, in healthy volunteers ages 40-64. The CoTend-s3BXBB vaccine includes a component called "s3", which was designed to improve the body's response to the vaccine. CoTend-BXBB is the same vaccine without s3. The main questions the study aims to answer are: 1) Is the investigational vaccine safe? 2) Does "s3" lead to bigger, broader, and longer-lasting responses to the vaccine? 5 different doses of the vaccines will be studied. Participants will receive a single dose of either CoTend-s3BXBB, CoTend-BXBB, or placebo. Participants will be monitored for side effects. Saliva, nasal, and blood samples will be collected and immune responses to the vaccine will be measured.
Conditions Studied
Interventions
- BIOLOGICAL Placebo
- BIOLOGICAL CoTend-BXBB (SARS2-30404)
- BIOLOGICAL CoTend-s3BXBB (SARS2-17032)
Study Locations (2)
California
- UCLA Westwood - Los Angeles
- UCSF Community and Clinical Research Center - San Francisco
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 80 participants |
| Start Date | 2025-10-21 |
| Est. Completion | 2029-10 |
| Phase | Phase 1 |
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT06810934
The ClinicalTrials.gov registry entry for NCT06810934 describes a study currently listed as recruiting, categorized as Phase 1. The registered enrollment target is 80 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 55,214-participant average among 203 other COVID-19 trials with a reported enrollment target (100% lower). The listed sponsor is Kara Chew, which has 1 total studies on file at ClinicalTrials.gov.
The record links to 2 conditions, with COVID-19 appearing as the primary indexed condition, and to 3 interventions - of which Placebo is the first listed.
NCT06810934 reports 2 study locations spanning 1 distinct geographic area - top geographies include California.
Frequently Asked Questions
What is clinical trial NCT06810934 about?
NCT06810934 is a clinical study titled "A Phase 1/2A, Randomized Study of a T Follicular Helper (TFH)-Targeting Genetic Vaccine Strategy Designed to Induce Broad, Durable Immune Responses". The goal of this clinical trial is to test two investigational COVID-19 booster vaccines, called CoTend-s3BXBB and CoTend-BXBB, in healthy volunteers ages 40-64. The CoTend-s3BXBB vaccine includes a component called "s3", which was designed to improve the body's response to the vaccine. CoTend-BXBB ...
What is the current status of trial NCT06810934?
This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 80 participants. The study started on 2025-10-21. Estimated completion is 2029-10.
What conditions does trial NCT06810934 study?
This clinical trial studies the following conditions: COVID-19, SARS CoV 2 Infection.
What interventions are being tested in trial NCT06810934?
The interventions under investigation include: Placebo (BIOLOGICAL), CoTend-BXBB (SARS2-30404) (BIOLOGICAL), CoTend-s3BXBB (SARS2-17032) (BIOLOGICAL).
Who is sponsoring clinical trial NCT06810934?
This trial is sponsored by Kara Chew, which has 1 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06810934 being conducted?
This trial has 2 study locations across California. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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Related
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