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RECRUITING Phase 4

Comparative Immunogenicity of Respiratory Virus Vaccines (CIRV2) Study

NCT07287137 · View on ClinicalTrials.gov ↗

Study Summary

CIRV2 is a Phase IV randomized, open-label, trial of FDA-approved COVID-19 and/or influenza vaccines (no more than minimal risk) with longitudinal follow-up. In 2025 CIRV2 will compare immunogenicity and reactogenicity of the recombinant Novavax COVID-19 vaccine and the mRNA Pfizer-BioNTech COVID-19 vaccine.

Interventions

  • DRUG Pfizer-BioNTech mRNA COVID-19 vaccine
  • DRUG Novavax recombinant protein vaccine

Study Locations (1)

Maryland

  • Walter Reed National Military Medical Center — Bethesda

Trial Details

FieldValue
Enrollment Target 54 participants
Start Date 2025-11-12
Est. Completion 2027-09
Phase Phase 4

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT07287137

The ClinicalTrials.gov registry entry for NCT07287137 describes a study currently listed as recruiting. It is categorized as Phase 4, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 54 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Henry M. Jackson Foundation for the Advancement of Military Medicine, which has 79 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 8 conditions, with Influenza appearing as the primary indexed condition, and to 2 interventions — of which Pfizer-BioNTech mRNA COVID-19 vaccine is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT07287137 reports 1 study location spanning 1 distinct geographic area — top geographies include Maryland. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT07287137 about?

NCT07287137 is a clinical study titled "Comparative Immunogenicity of Respiratory Virus Vaccines (CIRV2) Study". CIRV2 is a Phase IV randomized, open-label, trial of FDA-approved COVID-19 and/or influenza vaccines (no more than minimal risk) with longitudinal follow-up. In 2025 CIRV2 will compare immunogenicity and reactogenicity of the recombinant Novavax COVID-19 vaccine and the mRNA Pfizer-BioNTech COVID-19...

What is the current status of trial NCT07287137?

This trial is currently recruiting. It is a Phase 4 study. The enrollment target is 54 participants. The study started on 2025-11-12. Estimated completion is 2027-09.

What conditions does trial NCT07287137 study?

This clinical trial studies the following conditions: Influenza, COVID 19, COVID -19, Respiratory Virus, COVID - 19. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT07287137?

The interventions under investigation include: Pfizer-BioNTech mRNA COVID-19 vaccine (DRUG), Novavax recombinant protein vaccine (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT07287137?

This trial is sponsored by Henry M. Jackson Foundation for the Advancement of Military Medicine, which has 79 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT07287137 being conducted?

This trial has 1 study location across Maryland. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial