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ClinicalTrials.gov 57 recruiting now official registry

Coronary Artery Disease clinical trials

57 of 220 indexed Coronary Artery Disease trials are currently recruiting.

220 US clinical trials · 57 currently recruiting

Coronary Artery Disease is the subject of 220 registered US clinical trials on ClinicalTrials.gov, 57 of them currently open to new participants. 42 are in Phase 3-4 (later-stage) and 15 in Phase 1-2 (earlier-stage). The most active sponsor is University of Florida, running 17 of these trials.

The research picture

Coronary Artery Disease has 220 registered US clinical trials, 57 of them open to new participants right now, about 26% of the total.

57
recruiting participants now
26%
of trials open to enrollment
42
in Phase 3–4 (later-stage)
17
top sponsor: University of Florida
Phase 16Phase 29Phase 317Phase 425

Active & Recent Trials

220 total, page 3 of 5

COMPLETED 2,067 participants

An Observational Study of Cholesterol in Coronary Arteries

Infraredx

NCT00831116

COMPLETED Phase 4 2,009 participants

EVOLVE Short DAPT Study

Boston Scientific Corporation

NCT02605447

COMPLETED 2,000 participants

Genotype Information and Functional Testing Study

Scripps Health

NCT00992420

COMPLETED NA 1,629 participants

PIONEER III Trial to Assess Safety and Efficacy of the BuMA Supreme™ Drug Coated Coronary Stent in Patients With Coronary Disease

Sino Medical Sciences Technology

NCT03168776

COMPLETED Phase 3 1,530 participants

The PLATINUM Clinical Trial to Assess the PROMUS Element Stent System for Treatment of De Novo Coronary Artery Lesions

Boston Scientific Corporation

NCT00823212

COMPLETED 1,501 participants

PLATINUM Diversity

Boston Scientific Corporation

NCT02240810

COMPLETED Phase 2 1,326 participants

TAXUS IV-SR: Treatment of De Novo Coronary Disease Using a Single Paclitaxel-Eluting Stent

Boston Scientific Corporation

NCT00292474

COMPLETED Phase 3 1,264 participants

TAXUS PERSEUS Workhorse

Boston Scientific Corporation

NCT00484315

COMPLETED Phase 3 1,058 participants

Study of Sirolimus-Coated BX VELOCITY Balloon-Expandable Stent in Treatment of de Novo Native Coronary Artery Lesions (SIRIUS)

Cordis US

NCT00232765

COMPLETED 1,000 participants

Implementation of CYP2C19 Genotyping to Guide Antiplatelet Therapy

University of Florida

NCT02724319

COMPLETED 984 participants

Drug Eluting Stent Registry of Thrombosis

Medstar Health Research Institute

NCT00812552

COMPLETED Phase 4 949 participants

Type 2 Diabetes Evaluation of Ranolazine in Subjects With Chronic Stable Angina

Gilead Sciences

NCT01425359

COMPLETED NA 808 participants

Enhancing Recovery After Cardiac Surgery

University of California, Los Angeles

NCT00522717

COMPLETED Phase 4 777 participants

ISCHEMIA-Chronic Kidney Disease Trial

NYU Langone Health

NCT01985360

COMPLETED NA 698 participants

Radial Artery Access With Ultrasound Trial

University of California, Irvine

NCT01605292

COMPLETED NA 687 participants

Vitamins in Nitrous Oxide Study

Washington University School of Medicine

NCT00655980

COMPLETED Phase 3 682 participants

Safety and Efficacy Study Using ABT-335 (Investigational Drug) in Combination With Atorvastatin, to Study the Effects on Thickening of the Blood Vessel Wall in Patients With Abnormal Lipid (Fat) Levels in the Blood

AbbVie (prior sponsor, Abbott)

NCT00616772

COMPLETED 600 participants

Predictor of Advanced Subclinical Atherosclerosis

PreMD

NCT00245284

COMPLETED 597 participants

Retrospective Experience Of CIED Implantation

Elutia

NCT04351269

COMPLETED 581 participants

Coronary Obstruction Detection by Molecular Personalized Gene Expression (Corus CAD or ASGES)

CardioDx

NCT01117506

COMPLETED 571 participants

Role of Podocan and Wnt Pathway Regulatory Molecules in Coronary Artery Disease

Jennifer Victory, RN, CCRC

NCT02807714

COMPLETED Phase 3 478 participants

Gadobutrol / Gadavist-enhanced Cardiac Magnetic Resonance Imaging (CMRI) to Detect Coronary Artery Disease (CAD)

Bayer

NCT01890434

COMPLETED NA 452 participants

Improving Adherence to Post PCI Antiplatelet Therapy in Minority Populations

University of Miami

NCT01651208

COMPLETED NA 450 participants

OPTIMIZE PCI: Multicenter Randomized Trial of OCT Compared to IVUS and Angiography to Guide Coronary Stent Implantation

Abbott Medical Devices

NCT02471586

COMPLETED NA 447 participants

Enhancing Cardiac Rehabilitation Through Behavioral Nudges

Denver Health and Hospital Authority

NCT03834155

COMPLETED NA 431 participants

Disrupt CAD III With the Shockwave Coronary IVL System

Shockwave Medical

NCT03595176

COMPLETED Phase 3 426 participants

Gadobutrol/Gadavist-enhanced Cardiac Magnetic Resonance Imaging (CMRI) to Detect Coronary Artery Disease (CAD)

Bayer

NCT01890421

COMPLETED 418 participants

Observational Study of OCT in a Patients Undergoing FFR

Abbott Medical Devices

NCT01663896

COMPLETED 406 participants

Restore EF Observational Study

Abiomed

NCT04648306

COMPLETED NA 400 participants

Stress Echocardiography and Heart Computed Tomography (CT) Scan in Emergency Department Patients With Chest Pain

Montefiore Medical Center

NCT01384448

COMPLETED NA 400 participants

The Health Access and Recovery Peer Program

Emory University

NCT01725815

COMPLETED 370 participants

GUARD-AKI: Validation of AKI-Sapere in Cardiac Surgery Patients

Sapere Bio

NCT03635606

COMPLETED NA 355 participants

Hemostasis With QuikClot® Radial® Pad Versus TR Band® After Transradial Artery Access

Memorial Healthcare System

NCT03535597

COMPLETED Phase 4 351 participants

Periprocedural Glycemic Control in Patients Undergoing Coronary Angiography

NYU Langone Health

NCT01419652

COMPLETED 350 participants

Fractional Flow Reserve and Intravascular Ultrasound RelationShip STudy

Volcano Corporation

NCT01153555

COMPLETED Phase 2 340 participants

Targeting Inflammation Using Salsalate in CardioVascular Disease

Joslin Diabetes Center

NCT00624923

COMPLETED 330 participants

Frequency Analysis of Coronary Artery Disease

University of Minnesota

NCT01043237

COMPLETED NA 328 participants

The OMEGA Clinical Trial

Boston Scientific Corporation

NCT01419171

COMPLETED NA 296 participants

COBRA PZF™ Coronary Stent for Early Healing, Thrombus Inhibition, Endothelialization and Avoiding Long-Term DAPT

CeloNova BioSciences

NCT01925794

COMPLETED NA 287 participants

Evaluating a Low-Literacy Discharge Medication Education Tool

University of California, Los Angeles

NCT00408733

COMPLETED Phase 4 280 participants

Anti-inflammatory Effects of Colchicine in PCI

NYU Langone Health

NCT01709981

COMPLETED Phase 2 270 participants

MARS - Monitored Atherosclerosis Regression Study

Merck Sharp & Dohme

NCT00116870

COMPLETED NA 266 participants

Same Day Discharge (SDD) After Implantable Cardioverter Defibrillator (ICD) Implant

Abbott Medical Devices

NCT01993862

COMPLETED NA 241 participants

Clinical Investigation for Safety and Efficacy Study of CELT ACD (Arterial ClosureDevice)

Vasorum

NCT01600482

COMPLETED NA 227 participants

Exercise Cardiac Magnetic Resonance Imaging Accuracy for Cardiovascular Stress Testing

Ohio State University

NCT01592565

COMPLETED Phase 4 212 participants

The Platelet Aggregation After tiCagrelor Inhibition and FentanYl Trial (PACIFY)

Johns Hopkins University

NCT02683707

COMPLETED 201 participants

Non-Invasive EndoPAT Increases Diagnostic Yield of CAD by Coronary Angiography

Mayo Clinic

NCT01581671

COMPLETED NA 200 participants

Analysis of Surface EKG Signals to Identify Myocardial Dysfunction in Patients at Risk for Coronary Artery Disease

Icahn School of Medicine at Mount Sinai

NCT02560168

COMPLETED 198 participants

Determinants of Cardiac Risk Factor Modification in Latinos With Coronary Artery Disease

Weill Medical College of Cornell University

NCT00248859

COMPLETED 191 participants

WARRIOR Ancillary Study for CCTA Analysis

Cedars-Sinai Medical Center

NCT05035056

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Phase Distribution

PhaseTrial count
Phase 1 6
Phase 2 9
Phase 3 17
Phase 4 25

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Coronary Artery Disease Trial Landscape

220 indexed Coronary Artery Disease studies · 57 recruiting (26%).

Phase mix: 42 late (III/IV) vs 15 early (I/II).

Top sponsor: University of Florida (17 trials), 9 others listed. 50 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Coronary Artery Disease?

PlainTrial tracks 220 US clinical trials for Coronary Artery Disease, of which 57 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Coronary Artery Disease?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.