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Colorectal Cancer: early-phase trial registry
162 of 394 indexed Colorectal Cancer trials are currently recruiting, with more weight in Phase 1-2.
Corpus placement: #14 of 28,707 conditions by registered trial count.
394 US clinical trials · 162 currently recruiting · #14 of 28,707 conditions by registered trial count
Colorectal Cancer: 394 US clinical trials tracked, 162 recruiting.
Colorectal Cancer is the subject of 394 registered US clinical trials on ClinicalTrials.gov, 162 of them currently open to new participants. 13 are in Phase 3-4 (later-stage) and 201 in Phase 1-2 (earlier-stage). The most active sponsor is Memorial Sloan Kettering Cancer Center, running 22 of these trials.
Enrollment posture brief
Registry condition colorectal-cancer
OPEN 162 | RECR 41% | LATE 13 | EARLY 201 | RANK #14 | SPON 22
Volume-matched condition peers
Nearest open-share peer: Erectile Dysfunction (41% recruiting · 34 trials)
Colorectal Cancer lists 162 open slots (41% of 394 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Colorectal Cancer on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Colorectal Cancer is recruiting above its size-band peers.
162 of 394 indexed trials (41.1%) are open to enrollment, against a 37.1% average across 139 conditions with 100+ trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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Sponsorship of Colorectal Cancer trials is spread across many organizations.
Memorial Sloan Kettering Cancer Center accounts for 22 of 394 trials (5.6%). 222 distinct sponsors appear on at least one study for this condition label.
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Typical Colorectal Cancer enrolment sits around 132 participants.
Median target enrolment is 132 among the 382 trials that report a genuine target (sentinel values excluded). 162 of those (42.4%) plan for fewer than 100 participants.
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Colorectal Cancer research is mostly interventional.
323 interventional and 71 observational studies make up this index (82% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
394 total, page 5 of 8
Head to Head Pilot Trial of Mailed Cologuard to Mailed FIT
University of California, San Diego
NCT06173375
Phase I Study of Autologous CD8+ and CD4+ Engineered T Cell Receptor T Cells in Subjects With Advanced or Metastatic Solid Tumor
Affini-T Therapeutics
NCT06105021
A Safety, Tolerability and Efficacy Study of NC410 Plus Pembrolizumab in Participants with Advanced Unresectable or Metastatic Solid Tumors
NextCure
NCT05572684
Phase 1b Study to Evaluate ATP128, VSV-GP128 and BI 754091, in Patients With Stage IV Colorectal Cancer
Amal Therapeutics
NCT04046445
A Study of HFB200603 as a Single Agent and in Combination With Tislelizumab in Adult Patients With Advanced Solid Tumors
HiFiBiO Therapeutics
NCT05789069
Regorafenib and Pembrolizumab in Treating Participants With Advanced or Metastatic Colorectal Cancer
University of Southern California
NCT03657641
Platform Study of JDQ443 in Combinations in Patients With Advanced Solid Tumors Harboring the KRAS G12C Mutation
Novartis Pharmaceuticals
NCT05358249
Study of NGM438 as Monotherapy and in Combination With Pembrolizumab in Advanced or Metastatic Solid Tumors
NGM Biopharmaceuticals
NCT05311618
First in Human Study of TORL-3-600 in Participants With Advanced Cancer
TORL Biotherapeutics
NCT05948826
Study of the Monoclonal Antibody IMT-009 in Patients With Advanced Solid Tumors or Lymphomas
Immunitas Therapeutics
NCT05565417
Hepatic Arterial Infusion With Floxuridine and Dexamethasone Combined With Combination Chemotherapy in Treating Patients With Colorectal Cancer That Has Spread to the Liver
Memorial Sloan Kettering Cancer Center
NCT00492999
da Vinci SP® Investigational Device Exemption Study in Colorectal Procedures
Intuitive Surgical
NCT04403022
Colorectal Cancer Awareness, Research and Education and Screening - Rural Expansion, Access and Capacity for Health
H. Lee Moffitt Cancer Center and Research Institute
NCT04464668
Study of Cabozantinib and Nivolumab in Refractory Metastatic Microsatellite Stable (MSS) Colorectal Cancer
University of Colorado, Denver
NCT04963283
A Dose Escalation Study of HBI-2438 in Patients With Solid Tumors Harboring KRAS G12C Mutation
HUYABIO International
NCT05485974
A Dose Escalation Study of SHP2 Inhibitor in Patients With Solid Tumors Harboring KRAS of EGFR Mutations
HUYABIO International
NCT05163028
Evaluating Safety and Biomarkers Using DK210 (EGFR) for Locally Advanced or Metastatic EGFR+ Tumors
DEKA Biosciences
NCT05704985
Researching the Effect of Exercise on Cancer
Memorial Sloan Kettering Cancer Center
NCT04589468
Using an End-of-life Conversation Game to Engage Patients With Cancer in Advance Care Planning: Phase 2
Milton S. Hershey Medical Center
NCT06384417
Pooled Mutant KRAS-Targeted Long Peptide Vaccine Combined With Nivolumab and Ipilimumab for Patients With Resected Mismatch Repair Protein (MMR-p) Colorectal and Pancreatic Cancer
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
NCT04117087
Phase I Trial of Adagrasib (MRTX849) in Combination With Cetuximab and Irinotecan in Patients With Colorectal Cancer
M.D. Anderson Cancer Center
NCT05722327
Clinical Trial of All-trans-retinoic Acid, Bevacizumab and Atezolizumab in Colorectal Cancer
University of Texas Southwestern Medical Center
NCT05999812
Preliminary Investigation of β-hydroxybutyrate Supplementation in Colorectal Cancer Prevention
Abramson Cancer Center at Penn Medicine
NCT05338307
Study of Intravenous and Intraperitoneal Paclitaxel and Oral Nilotinib for Peritoneal Carcinomatosis From Colorectal, Appendiceal, Small Bowel, Gastric, Cholangiocarcinoma, Breast, Ovarian, or Other Gynecologic Primary Cancer
National Cancer Institute (NCI)
NCT05185947
Adoptive Cell Therapy Using Cancer Specific CD8+ Tumor Infiltrating Lymphocytes in Adult Patients With Solid Tumors
AgonOx
NCT05902520
Botensilimab and Balstilimab Optimization in Colorectal Cancer
Nicholas DeVito, MD
NCT06268015
QUILT-2.025 NANT Neoepitope Yeast Vaccine (YE-NEO-001): Adjuvant Immunotherapy Using a Personalized Neoepitope Yeast-Based Vaccine To Induce T-Cell Responses In Subjects W/ Previously Treated Cancers.
NantBioScience
NCT03552718
Study of Cabozantinib Plus TAS102 in mCRC as Salvage Therapy
University of California, Irvine
NCT04868773
Abnormal Food Timing and Circadian Dyssynchrony in Alcohol Induced Colon Carcinogenesis
Rush University Medical Center
NCT03955510
A Phase 1/2 Trial of TC-510 In Patients With Advanced Mesothelin-Expressing Cancer
TCR2 Therapeutics
NCT05451849
EGF-Depleting Therapy CIMAvax-EGF in Combination With Standard Therapy for RAS- and BRAF Wild-Type Metastatic Colorectal Cancer
Roswell Park Cancer Institute
NCT06011772
Evaluation of the ctDNA LUNAR Test in an Average Patient Screening Episode
Guardant Health
NCT04136002
Computerized and Mailed Reminders in Increasing the Rate of Colorectal Cancer Screening in Adults With an Average Risk for Colorectal Cancer
Harvard Medical School (HMS and HSDM)
NCT00355004
Blood and Tissue Sample Collection for Future Colon Cancer Biomarker Studies in Patients Undergoing Colonoscopy
Vanderbilt University
NCT00897403
Mailed FIT Outreach 2022
Abramson Cancer Center at Penn Medicine
NCT05341622
Evaluation of an Intervention to Increase Colorectal Cancer Screening in Primary Care Clinics
Centers for Disease Control and Prevention
NCT00737646
Effect of Patient Portal Messaging Before Mailing Fecal Immunochemical Testing Kit on Colorectal Cancer Screening Rates
University of California, Los Angeles
NCT05115916
A Telephone-Based Prevention Care Manager in Increasing Screening Rates for Breast Cancer, Cervical Cancer, and Colorectal Cancer in Minority and Low-Income Women
Dartmouth-Hitchcock Medical Center
NCT00376909
Reminder Modality for CRC Screening
VA Puget Sound Health Care System
NCT05012007
Cancer Prevention and Treatment Demonstration for Ethnic and Racial Minorities
M.D. Anderson Cancer Center
NCT00453661
A Study of Cologuard™ in an Average Risk Population Assessing a Three Year Test Interval
Exact Sciences Corporation
NCT02419716
Veteran Primers for CRC Screening
VA Puget Sound Health Care System
NCT04923646
Helping Women Stay Up-To-Date With Cancer Screening By Using a Prevention Care Manager or Usual Care
Dartmouth-Hitchcock Medical Center
NCT00477646
Online Study of Colorectal Cancer and Prostate Cancer Screening Decision Making
University of North Carolina, Chapel Hill
NCT01558583
A Patient Portal Tool, E-assist, for Supporting CRC Screening
UNC Lineberger Comprehensive Cancer Center
NCT02798224
Genetic Study of Patients and Families With a History of Colorectal Cancer
Alliance for Clinical Trials in Oncology
NCT00003648
PRospective REgistry of Advanced Stage CancER (PREFER) Patients to Assess Prevalence of Actionable Biomarkers and Driver Mutations to Address Disparities in Precision Medicine
Labcorp Corporation of America Holdings
NCT05697198
The FLU-FOBT Program in Primary Care Settings Where Disparities Persist
University of California, San Francisco
NCT01211379
Water-aided Colonoscopy vs Air Insufflation Colonoscopy in Colorectal Cancer Screening
Presidio Ospedaliero Santa Barbara
NCT02041507
Predicting and Addressing Colonoscopy in Safety Net Settings
Kaiser Permanente
NCT03925883
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 132 |
| Phase 2 | 69 |
| Phase 3 | 10 |
| Phase 4 | 3 |
Top Sponsors
Named interventions
Most-linked intervention names on Colorectal Cancer records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Colorectal Cancer trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Colorectal Cancer page
394 registered trials, 162 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 162 Colorectal Cancer trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- Memorial Sloan Kettering Cancer Center sponsors the most Colorectal Cancer trials on record, review their full trial history before evaluating a specific study. See Memorial Sloan Kettering Cancer Center's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Colorectal Cancer condition card totals 394 registered trials; most-linked intervention Cetuximab; top US site state California. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.