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NCT05722327 · ClinicalTrials.gov registry record · Phase 1
Phase I Trial of Adagrasib (MRTX849) in Combination With Cetuximab and Irinotecan in Patients With Colorectal Cancer
A Phase 1 study of Colorectal Cancer and Colon Cancer, sponsored by M.D. Anderson Cancer Center.
- Active
- Registry status
- Phase 1
- Development phase
- 24
- Enrollment target
- 1
- Study location
NCT05722327: Active Phase 1 study of Colorectal Cancer and Colon Cancer, sponsored by M.D. Anderson Cancer Center.
NCT05722327 is a Phase 1 study of Colorectal Cancer and Colon Cancer that is active but no longer recruiting, run by M.D. Anderson Cancer Center. The registered enrollment target is 24 participants, below the 1,545-participant average among 381 other Colorectal Cancer trials with a reported enrollment target (98% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05722327, a Phase 1 study of Colorectal Cancer and Colon Cancer, is active but no longer recruiting, sponsored by M.D. Anderson Cancer Center.
- ACTIVE NOT RECRUITING
- Registry status
- Phase 1
- Development phase
- 24 participants
- Enrollment target
- 1
- Study location
Study Summary
To find the recommended dose of MRTX849 that can be given in combination with cetuximab and irinotecan to patients with colorectal cancer that have a mutation (genetic change) called KRAS G12C.
Conditions Studied
Interventions
- DRUG Cetuximab
- DRUG Irinotecan
- DRUG MRTX849
Study Locations (1)
Texas
- M D Anderson Cancer Center - Houston
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 24 participants |
| Start Date | 2023-12-06 |
| Est. Completion | 2027-09-30 |
| Phase | Phase 1 |
What the registry record for NCT05722327 still lists
NCT05722327 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 24 participants, a relatively small participant target, below the 1,545-participant average among 381 other Colorectal Cancer trials with a reported enrollment target (98% lower).
The record links to 2 conditions, with Colorectal Cancer appearing as the primary indexed condition, and to 3 interventions - of which Cetuximab is the first listed.
NCT05722327 reports a single indexed study location in Texas.
Frequently Asked Questions
What is clinical trial NCT05722327 about?
NCT05722327 is a clinical study titled "Phase I Trial of Adagrasib (MRTX849) in Combination With Cetuximab and Irinotecan in Patients With Colorectal Cancer". To find the recommended dose of MRTX849 that can be given in combination with cetuximab and irinotecan to patients with colorectal cancer that have a mutation (genetic change) called KRAS G12C.
What is the current status of trial NCT05722327?
This trial is currently active not recruiting. It is a Phase 1 study. The enrollment target is 24 participants. The study started on 2023-12-06. Estimated completion is 2027-09-30.
What conditions does trial NCT05722327 study?
This clinical trial studies the following conditions: Colorectal Cancer, Colon Cancer.
What interventions are being tested in trial NCT05722327?
The interventions under investigation include: Cetuximab (DRUG), Irinotecan (DRUG), MRTX849 (DRUG).
Who is sponsoring clinical trial NCT05722327?
This trial is sponsored by M.D. Anderson Cancer Center, which has 2,692 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05722327 being conducted?
This trial has 1 study location across Texas. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Colorectal Cancer
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT05722327's enrollment target sits among peer trials
24 333rd of 381 higher than 44 of 381 other Colorectal Cancer trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Colorectal Cancer trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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