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NCT05485974 · ClinicalTrials.gov registry record · Phase 1
A Dose Escalation Study of HBI-2438 in Patients With Solid Tumors Harboring KRAS G12C Mutation
A Phase 1 study of Cancer and Non-Small Cell Lung Cancer, sponsored by HUYABIO International.
- Active
- Registry status
- Phase 1
- Development phase
- 44
- Enrollment target
- 14
- Study locations
NCT05485974 is a Phase 1 study of Cancer and Non-Small Cell Lung Cancer that is active but no longer recruiting, run by HUYABIO International. The registered enrollment target is 44 participants, below the 3,491-participant average among 615 other Cancer trials with a reported enrollment target (99% lower). The trial reports 14 study locations across 6 states.
The verdict
NCT05485974, a Phase 1 study of Cancer and Non-Small Cell Lung Cancer, is active but no longer recruiting, sponsored by HUYABIO International.
- ACTIVE NOT RECRUITING
- Registry status
- Phase 1
- Development phase
- 44 participants
- Enrollment target
- 14
- Study locations
Study Summary
A Phase 1 dose escalation study in patients with advanced solid tumors harboring KRAS G12C mutation to determine the maximum tolerated dose and recommended Phase II dose of HBI-2438 and characterize its pharmacokinetic profile.
Conditions Studied
Interventions
- DRUG HBI-2438
Study Locations (14)
California
- California Cancer Associates for Research and Excellence, Inc. (cCare) - Encinitas
- The Oncology Institute of Hope and Innovation - Glendale
- The Oncology Institute of Hope and Innovation - Long Beach
- The Oncology Institute of Hope and Innovation - Pasadena
- California Cancer Associates for Research and Excellence, Inc. (cCare) - San Marcos
- The Oncology Institute of Hope and Innovation - Santa Ana
- Sarcoma Oncology - Santa Monica
- Innovative Clinical Research Institute (ICRI) - Whittier
- The Oncology Institute of Hope and Innovation - Whittier
Florida
- BRCR Medical Center - Plantation
Michigan
- Michigan Center of Medical Research - Farmington Hills
Missouri
- Alliance for Multispecialty Research, LLC - Kansas City
Ohio
- Gabrail Cancer Center - Canton
Puerto Rico
- Pan American Center for Oncology Trials (PanOncology Trials) - Rio Piedras
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 44 participants |
| Start Date | 2022-08-01 |
| Est. Completion | 2026-12-31 |
| Phase | Phase 1 |
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT05485974
The ClinicalTrials.gov registry entry for NCT05485974 describes a study currently listed as active not recruiting, categorized as Phase 1. The registered enrollment target is 44 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 3,491-participant average among 615 other Cancer trials with a reported enrollment target (99% lower). The listed sponsor is HUYABIO International, which has 7 total studies on file at ClinicalTrials.gov.
The record links to 7 conditions, with Cancer appearing as the primary indexed condition, and to 1 intervention - of which HBI-2438 is the first listed.
NCT05485974 reports 14 study locations spanning 6 distinct geographic areas - top geographies include California, Florida, Michigan.
Frequently Asked Questions
What is clinical trial NCT05485974 about?
NCT05485974 is a clinical study titled "A Dose Escalation Study of HBI-2438 in Patients With Solid Tumors Harboring KRAS G12C Mutation". A Phase 1 dose escalation study in patients with advanced solid tumors harboring KRAS G12C mutation to determine the maximum tolerated dose and recommended Phase II dose of HBI-2438 and characterize its pharmacokinetic profile.
What is the current status of trial NCT05485974?
This trial is currently active not recruiting. It is a Phase 1 study. The enrollment target is 44 participants. The study started on 2022-08-01. Estimated completion is 2026-12-31.
What conditions does trial NCT05485974 study?
This clinical trial studies the following conditions: Cancer, Non-Small Cell Lung Cancer, Lung Cancer, Colorectal Cancer, Solid Tumor.
What interventions are being tested in trial NCT05485974?
The interventions under investigation include: HBI-2438 (DRUG).
Who is sponsoring clinical trial NCT05485974?
This trial is sponsored by HUYABIO International, which has 7 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05485974 being conducted?
This trial has 14 study locations across California, Florida, Michigan, Missouri, Ohio. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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