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NCT03657641 · ClinicalTrials.gov registry record · Phase 1
Regorafenib and Pembrolizumab in Treating Participants With Advanced or Metastatic Colorectal Cancer
A Phase 1 study of Colorectal Cancer and Colorectal Cancer Metastatic, sponsored by University of Southern California.
- Active
- Registry status
- Phase 1
- Development phase
- 75
- Enrollment target
- 3
- Study locations
NCT03657641 is a Phase 1 study of Colorectal Cancer and Colorectal Cancer Metastatic that is active but no longer recruiting, run by University of Southern California. The registered enrollment target is 75 participants, below the 1,511-participant average among 369 other Colorectal Cancer trials with a reported enrollment target (95% lower). The trial reports 3 study locations across 2 states.
The verdict
NCT03657641, a Phase 1 study of Colorectal Cancer and Colorectal Cancer Metastatic, is active but no longer recruiting, sponsored by University of Southern California.
- ACTIVE NOT RECRUITING
- Registry status
- Phase 1
- Development phase
- 75 participants
- Enrollment target
- 3
- Study locations
Study Summary
This phase I/II studies the side effects and best dose of regorafenib when given together with pembrolizumab in treating participants with colorectal cancer that has spread to other places in the body. Drugs used in chemotherapy, such as regorafenib, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Monoclonal antibodies, such as pembrolizumab, may interfere with the ability of tumor cells to grow and spread. Giving regorafenib and pembrolizumab may work better at treating colorectal cancer.
Conditions Studied
Interventions
- BIOLOGICAL Pembrolizumab
- DRUG Regorafenib
Study Locations (3)
California
- City of Hope - Duarte
- USC / Norris Comprehensive Cancer Center - Los Angeles
Florida
- Moffitt Cancer Center - Tampa
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 75 participants |
| Start Date | 2019-06-21 |
| Est. Completion | 2026-06-21 |
| Phase | Phase 1 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT03657641
The ClinicalTrials.gov registry entry for NCT03657641 describes a study currently listed as active not recruiting, categorized as Phase 1. The registered enrollment target is 75 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 1,511-participant average among 369 other Colorectal Cancer trials with a reported enrollment target (95% lower). The listed sponsor is University of Southern California, which has 617 total studies on file at ClinicalTrials.gov.
The record links to 2 conditions, with Colorectal Cancer appearing as the primary indexed condition, and to 2 interventions - of which Pembrolizumab is the first listed.
NCT03657641 reports 3 study locations spanning 2 distinct geographic areas - top geographies include California, Florida.
Frequently Asked Questions
What is clinical trial NCT03657641 about?
NCT03657641 is a clinical study titled "Regorafenib and Pembrolizumab in Treating Participants With Advanced or Metastatic Colorectal Cancer". This phase I/II studies the side effects and best dose of regorafenib when given together with pembrolizumab in treating participants with colorectal cancer that has spread to other places in the body. Drugs used in chemotherapy, such as regorafenib, work in different ways to stop the growth of tumo...
What is the current status of trial NCT03657641?
This trial is currently active not recruiting. It is a Phase 1 study. The enrollment target is 75 participants. The study started on 2019-06-21. Estimated completion is 2026-06-21.
What conditions does trial NCT03657641 study?
This clinical trial studies the following conditions: Colorectal Cancer, Colorectal Cancer Metastatic.
What interventions are being tested in trial NCT03657641?
The interventions under investigation include: Pembrolizumab (BIOLOGICAL), Regorafenib (DRUG).
Who is sponsoring clinical trial NCT03657641?
This trial is sponsored by University of Southern California, which has 617 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT03657641 being conducted?
This trial has 3 study locations across California, Florida. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page mirrors this trial's own ClinicalTrials.gov registry record, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.