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Colorectal Cancer: early-phase trial registry
162 of 394 indexed Colorectal Cancer trials are currently recruiting, with more weight in Phase 1-2.
Corpus placement: #14 of 28,707 conditions by registered trial count.
394 US clinical trials · 162 currently recruiting · #14 of 28,707 conditions by registered trial count
Colorectal Cancer: 394 US clinical trials tracked, 162 recruiting.
Colorectal Cancer is the subject of 394 registered US clinical trials on ClinicalTrials.gov, 162 of them currently open to new participants. 13 are in Phase 3-4 (later-stage) and 201 in Phase 1-2 (earlier-stage). The most active sponsor is Memorial Sloan Kettering Cancer Center, running 22 of these trials.
Enrollment posture brief
Registry condition colorectal-cancer
OPEN 162 | RECR 41% | LATE 13 | EARLY 201 | RANK #14 | SPON 22
Volume-matched condition peers
Nearest open-share peer: Erectile Dysfunction (41% recruiting · 34 trials)
Colorectal Cancer lists 162 open slots (41% of 394 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Colorectal Cancer on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Colorectal Cancer is recruiting above its size-band peers.
162 of 394 indexed trials (41.1%) are open to enrollment, against a 37.1% average across 139 conditions with 100+ trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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Sponsorship of Colorectal Cancer trials is spread across many organizations.
Memorial Sloan Kettering Cancer Center accounts for 22 of 394 trials (5.6%). 222 distinct sponsors appear on at least one study for this condition label.
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Typical Colorectal Cancer enrolment sits around 132 participants.
Median target enrolment is 132 among the 382 trials that report a genuine target (sentinel values excluded). 162 of those (42.4%) plan for fewer than 100 participants.
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Colorectal Cancer research is mostly interventional.
323 interventional and 71 observational studies make up this index (82% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
394 total, page 6 of 8
Prospective Trial to Compare the Clinical Efficiency of G-EYE™ HD Colonoscopy With Standard HD Colonoscopy
Smart Medical Systems
NCT01917513
Blood Collection Sub-Study for CRC Screening in Individuals 45-49 at Average Risk for CRC.
Exact Sciences Corporation
NCT03741166
Blood and Stool Sample Collection in Subjects With a Diagnosis of Colorectal Cancer or Colorectal Lesion: Act Fast
Exact Sciences Corporation
NCT03789162
Laparoscopic-Assisted Surgery Compared With Open Surgery in Treating Patients With Colon Cancer
Alliance for Clinical Trials in Oncology
NCT00002575
A Comparison of Methods to Detect Polyps During Colonoscopy
The Cleveland Clinic
NCT01025960
Interventions to Improve Colon Cancer Screening in Poor Rural Iowa Counties
Barcey T. Levy
NCT01477814
Genetic Epidemiology Risk Assessment Program or Usual Care in Colorectal Cancer Screening for Healthy Participants
Fox Chase Cancer Center
NCT00478309
Interactive Computer Program or Brochure in Increasing Colorectal Cancer Screening Among African Americans
Indiana University
NCT00672828
Aspirin in Treating Patients With Colorectal Cancer That Has Been Surgically Removed
Alliance for Clinical Trials in Oncology
NCT00002527
A Study of Xeloda (Capecitabine) in Patients With Metastatic Colorectal Cancer
Hoffmann-La Roche
NCT00069108
Genetic Study in Patients With Stage II or Stage III Colon Cancer
Alliance for Clinical Trials in Oncology
NCT00003833
Use and Decision-making About Colorectal Cancer Screening Among Hispanic Men and Women
Centers for Disease Control and Prevention
NCT00136227
Promoting Colorectal Cancer Screening in Rural Colorado
Centers for Disease Control and Prevention
NCT00137592
Online Trial Examining Validity of the Shared Decision Making Process Survey With Video Vignettes
Massachusetts General Hospital
NCT04317274
Caring for Those Who Share: Improving the Health of Wisconsin Blood Donors
Medical College of Wisconsin
NCT00772083
Assessing the Effect of a Blood-based Colorectal Cancer Screening Test on Screening Adherence and Colonoscopy Completion
Peter S. Liang, MD MPH
NCT03598166
Evaluation of the Efficacy of National Cancer Institute's Facing Forward Booklet in the Cancer Community Setting
Fox Chase Cancer Center
NCT01440855
Collection of Patient-Reported Symptoms and Performance Status Via the Internet
Alliance for Clinical Trials in Oncology
NCT00417040
Genetic Trial to Study Diarrhea in Patients With Stage III Colon Cancer Who Are Receiving Chemotherapy
Alliance for Clinical Trials in Oncology
NCT00048971
Redes III Patient Navigator Qol Study
The University of Texas Health Science Center at San Antonio
NCT02275754
Gene Testing in Patients With Colon Cancer
Alliance for Clinical Trials in Oncology
NCT00003571
Understanding Patient Preference on Colorectal Cancer Screening Options-PSU
Milton S. Hershey Medical Center
NCT06444542
Study of Flat Polyp Detection Using New Narrow Band Imaging (NBI) Compared to White Light Colonoscopy - The FIND FLAT Colonoscopy Study
VA Palo Alto Health Care System
NCT01310699
An Observational Pilot Study Evaluating the Feasibility of Conducting Genome-Wide Association Studies Utilizing Subject Provided Information in Subjects With Locally Recurrent or MBC, MCRC, MNSCLC, RGBM or MRCC Treated With Avastin (Bevacizumab) (InVite)
Genentech
NCT01598597
Screening for Familial Colorectal Cancer (CRC) Patients
M.D. Anderson Cancer Center
NCT00632515
Calcium: Magnesium Balance, Microbiota, and Necroptosis and Inflammation
Vanderbilt University Medical Center
NCT04229992
Comparative Effectiveness of CTC & OC
Fox Chase Cancer Center
NCT02143115
A Study of LY2880070 in Participants With Advanced or Metastatic Cancer
Esperas Pharma
NCT02632448
Health Behaviors in Patients Who Have Finished Treatment for Stage I, Stage II, or Stage III Colorectal Cancer
Rutgers, The State University of New Jersey
NCT00966667
Colon Cancer Prevention Study
University of North Carolina, Chapel Hill
NCT00924690
Phase 1b/2 Study of AMG 655 With mFOLFOX6 and Bevacizumab for First-Line Metastatic Colorectal Cancer
Amgen
NCT00625651
Evaluating Length of Treatment With PD-1/PD-L1 Inhibitor in Advanced Solid Tumors
Dan Zandberg
NCT04157985
Patient-Centered Intervention to Reduce Cancer Patients' Financial Toxicity
Washington University School of Medicine
NCT04314284
Efficacy and Patient Satisfaction of Miralax and Gatorade Versus Movi Prep
Rush University Medical Center
NCT01695863
S1013: Validation of Cancer Questionnaire for Skin Toxicities in Patients With Colorectal Cancer or Lung Cancer Receiving Cetuximab, Panitumumab, or Erlotinib Hydrochloride
SWOG Cancer Research Network
NCT01416688
Early Post-Op Recovery After Partial Large Bowel Resection
University Hospitals Cleveland Medical Center
NCT00492193
A Study of SAR444245 Combined With Other Anticancer Therapies for the Treatment of Participants With Gastrointestinal Cancer (Master Protocol) (Pegathor Gastrointestinal 203)
Sanofi
NCT05104567
Predicting Local and Distant Recurrence in T1 Colorectal Cancer
City of Hope Medical Center
NCT06314971
Irinotecan Hydrochloride and Cetuximab With or Without Ramucirumab in Treating Patients With Advanced Colorectal Cancer With Progressive Disease After Treatment With Bevacizumab-Containing Chemotherapy
Eastern Cooperative Oncology Group
NCT01079780
Safety and Efficacy Study of MEHD7945A + FOLFIRI Versus Cetuximab + FOLFIRI as Second Line Therapy in Participants With KRAS Wild-Type Metastatic Colorectal Cancer (mCRC)
Genentech
NCT01652482
Combination Chemotherapy in Treating Patients With Liver Metastases From Colorectal Cancer
Alliance for Clinical Trials in Oncology
NCT00002716
Trial of a Multilevel Intervention to Increase Colorectal Cancer Screening
NYU Langone Health
NCT00836303
A Culturally-adapted Colorectal Cancer Screening Decision Aid Designed for American Indians
UNC Lineberger Comprehensive Cancer Center
NCT03569761
The Deep South Surgical Equity Research Network: Addressing Socioecological Determinants of Health
University of Alabama at Birmingham
NCT05345054
Visceral Lymphatic Mapping Using Isosulfan Blue in Patients With Cancer of the Pancreas, Colon, Stomach, Small Intestine, or Gallbladder
Wake Forest University Health Sciences
NCT00489515
Prospective Analysis of Hypersensitivity Reactions to Oxaliplatin
Dana-Farber Cancer Institute
NCT00831571
A Safety, Pharmacokinetic and Efficacy Study of NUC-3373 in Combination With Standard Agents Used in Colorectal Cancer Treatment
NuCana
NCT03428958
Calcium Gluconate and Magnesium Sulfate in Preventing Neurotoxicity Caused By Oxaliplatin in Patients Receiving Combination Chemotherapy for Stage II, Stage III, or Stage IV Colorectal Cancer That Has Been Completely Removed By Surgery
Alliance for Clinical Trials in Oncology
NCT00316914
Intraoperative TAP Block With Bupivacaine/Dexamethasone Against Liposomal Bupivacaine (Exparel®)
Cedars-Sinai Medical Center
NCT03723447
Study of CS-7017 in Combination With FOLFIRI in Subjects With Metastatic Colorectal Cancer Who Failed First-Line Therapy
Daiichi Sankyo
NCT00967616
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 132 |
| Phase 2 | 69 |
| Phase 3 | 10 |
| Phase 4 | 3 |
Top Sponsors
Named interventions
Most-linked intervention names on Colorectal Cancer records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Colorectal Cancer trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Colorectal Cancer page
394 registered trials, 162 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 162 Colorectal Cancer trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- Memorial Sloan Kettering Cancer Center sponsors the most Colorectal Cancer trials on record, review their full trial history before evaluating a specific study. See Memorial Sloan Kettering Cancer Center's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Colorectal Cancer condition card totals 394 registered trials; most-linked intervention Cetuximab; top US site state California. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.