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NCT05195398 · ClinicalTrials.gov registry record · NA
TDCS to Improve Post-Stroke Cognitive Impairment
A NA study of Stroke and Cognitive Impairment, sponsored by Johns Hopkins University.
- Recruiting
- Registry status
- NA
- Development phase
- 60
- Enrollment target
- 1
- Study location
NCT05195398: Recruiting NA study of Stroke and Cognitive Impairment, sponsored by Johns Hopkins University.
NCT05195398 is a NA study of Stroke and Cognitive Impairment that is actively recruiting participants, run by Johns Hopkins University. The registered enrollment target is 60 participants, below the 12,016-participant average among 454 other Stroke trials with a reported enrollment target (100% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05195398, a NA study of Stroke and Cognitive Impairment, is actively recruiting participants, sponsored by Johns Hopkins University.
- RECRUITING
- Registry status
- NA
- Development phase
- 60 participants
- Enrollment target
- 1
- Study location
Study Summary
The investigators will conduct a randomized, double-blinded, sham-controlled trial of approximately 60 patients with minor stroke and post-stroke mild cognitive impairment (psMCI). Participants will be individually randomized on enrollment using a random number generator to treatment with anodal tDCS + computerized cognitive treatment (CCT) versus sham + CCT (approximately 30 patients in each arm). Clinical evaluation including assessment of cognition will be performed pre- and post-intervention by individuals on the study team blinded to the participant's intervention. Participants will also undergo functional neuroimaging with magnetoencephalography (MEG) pre- and post-intervention (1, 3, and 6 months post-stroke to evaluate for initial and longer-term effects of treatment on cerebral activation patterns and functional connectivity). Neuroimaging and clinical outcomes will be assessed to determine the effect of tDCS versus sham + CCT on psMCI.
Primary Outcome
Our cognitive battery was designed to efficiently evaluate for psMCI. It combines the Montreal Cognitive Assessment, Grooved Pegboard, Hopkins Verbal Learning Test, Brief Visuospatial Memory Test, Delis-Kaplan Executive Function System, and Symbol Digit Modalities Test. T scores are averaged across tasks and calculated for the following cognitive domains: verbal memory, spatial memory, processing speed, motor speed, executive function, and global cognition.
Conditions Studied
Interventions
- DEVICE Sham Intervention
- DEVICE Anodal transcranial Direct Current Stimulation (A-tDCS)
Study Locations (1)
Maryland
- Johns Hopkins Bayview Medical Center - Baltimore
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 60 participants |
| Start Date | 2022-09-01 |
| Est. Completion | 2027-08-31 |
| Phase | NA |
What NCT05195398 shows while recruiting
NCT05195398 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 60 participants, a relatively small participant target, below the 12,016-participant average among 454 other Stroke trials with a reported enrollment target (100% lower).
The record links to 3 conditions, with Stroke appearing as the primary indexed condition, and to 2 interventions - of which Sham Intervention is the first listed.
NCT05195398 reports a single indexed study location in Maryland.
Frequently Asked Questions
What is clinical trial NCT05195398 about?
NCT05195398 is a clinical study titled "TDCS to Improve Post-Stroke Cognitive Impairment". The investigators will conduct a randomized, double-blinded, sham-controlled trial of approximately 60 patients with minor stroke and post-stroke mild cognitive impairment (psMCI). Participants will be individually randomized on enrollment using a random number generator to treatment with anodal tDC...
What is the current status of trial NCT05195398?
This trial is currently recruiting. It is a NA study. The enrollment target is 60 participants. The study started on 2022-09-01. Estimated completion is 2027-08-31.
What conditions does trial NCT05195398 study?
This clinical trial studies the following conditions: Stroke, Cognitive Impairment, Stroke Sequelae.
What interventions are being tested in trial NCT05195398?
The interventions under investigation include: Sham Intervention (DEVICE), Anodal transcranial Direct Current Stimulation (A-tDCS) (DEVICE).
Who is sponsoring clinical trial NCT05195398?
This trial is sponsored by Johns Hopkins University, which has 1,448 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05195398 being conducted?
This trial has 1 study location across Maryland. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Stroke
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT05195398's enrollment target sits among peer trials
60 206th of 454 higher than 236 of 454 other Stroke trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Stroke trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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