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NCT04874636 · ClinicalTrials.gov registry record · Phase 2
Chronic Pain Master Protocol (CPMP): A Study of LY3556050 in Participants With Chronic Low Back Pain
A Phase 2 study of Chronic Low Back Pain, sponsored by Eli Lilly and Company.
- Completed
- Registry status
- Phase 2
- Development phase
- 153
- Enrollment target
- 20
- Study locations
NCT04874636: Completed Phase 2 study of Chronic Low Back Pain, sponsored by Eli Lilly and Company.
NCT04874636 is a Phase 2 study of Chronic Low Back Pain that has completed, run by Eli Lilly and Company. The registered enrollment target is 153 participants, below the 590-participant average among 71 other Chronic Low Back Pain trials with a reported enrollment target (74% lower). The trial reports 20 study locations across 6 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04874636, a Phase 2 study of Chronic Low Back Pain, has completed, sponsored by Eli Lilly and Company.
- COMPLETED
- Registry status
- Phase 2
- Development phase
- 153 participants
- Enrollment target
- 20
- Study locations
Study Summary
This study is being done to test the safety and efficacy of the study drug LY3556050 for the treatment of chronic low back pain. This trial is part of the chronic pain master protocol H0P-MC-CPMP (NCT05986292) which is a protocol to accelerate the development of new treatments for chronic pain.
Primary Outcome
The NRS was used to describe pain severity. Participants were asked to describe their average pain over the past 24 hours, on a scale of 0 to 10: 0 = no pain, and 10 = pain as bad as you can imagine. Posterior mean change from baseline, 95 percent (%) credible interval was derived using Bayesian mixed model repeated measures. Data presented are posterior mean with 95% credible interval.
Conditions Studied
Interventions
- DRUG Placebo
- DRUG LY3556050
Study Locations (20)
Florida
- VIN-Julie Schwartzbard - Aventura
- Clinical Research of South Florida - Coral Gables
- Suncoast Research Group - Miami
- University of Miami Don Suffer Clinical Research Building - Miami
- New Horizon Research Center - Miami
- Renstar Medical Research - Ocala
- Synexus Clinical Research US, Inc - Orlando - Orlando
- Synexus Clinical Research - St. Petersburg - Pinellas Park
- Martin E. Hale M.D., P.A. - Plantation
- Synexus Clinical Research US, Inc - Orlando - The Villages
Arizona
- Synexus- Chandler - Chandler
- Synexus Clinical Research - Glendale - Glendale
- Alliance for Multispecialty Research - Clinical Research Consortium - Tempe
California
- Irvine Clinical Research Center - Irvine
- Artemis Institute for Clinical Research - Riverside
- Artemis Institute for Clinical Research - San Diego
Illinois
- Synexus Clinical Research - Chicago
- Northwestern University - Chicago
Alabama
- Simon Williamson Clinic - Birmingham
Connecticut
- CMR of Greater New Haven - Hamden
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 153 participants |
| Start Date | 2021-05-20 |
| Est. Completion | 2022-02-09 |
| Phase | Phase 2 |
What the finished NCT04874636 record still lists
NCT04874636 is an interventional study that assigns participants to a tested intervention. The registered 153 participants enrollment target is mid-sized for trials with a published cap, below the 590-participant average among 71 other Chronic Low Back Pain trials with a reported enrollment target (74% lower).
The record links to 1 condition, with Chronic Low Back Pain appearing as the primary indexed condition, and to 2 interventions - of which Placebo is the first listed.
NCT04874636 names 20 study sites across 6 states, led by Florida, Arizona, California.
Frequently Asked Questions
What is clinical trial NCT04874636 about?
NCT04874636 is a clinical study titled "Chronic Pain Master Protocol (CPMP): A Study of LY3556050 in Participants With Chronic Low Back Pain". This study is being done to test the safety and efficacy of the study drug LY3556050 for the treatment of chronic low back pain. This trial is part of the chronic pain master protocol H0P-MC-CPMP (NCT05986292) which is a protocol to accelerate the development of new treatments for chronic pain.
What is the current status of trial NCT04874636?
This trial is currently completed. It is a Phase 2 study. The enrollment target is 153 participants. The study started on 2021-05-20. Estimated completion is 2022-02-09.
What conditions does trial NCT04874636 study?
This clinical trial studies the following conditions: Chronic Low Back Pain.
What interventions are being tested in trial NCT04874636?
The interventions under investigation include: Placebo (DRUG), LY3556050 (DRUG).
Who is sponsoring clinical trial NCT04874636?
This trial is sponsored by Eli Lilly and Company, which has 1,341 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT04874636 being conducted?
This trial has 20 study locations across Alabama, Arizona, California, Connecticut, Florida. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Chronic Low Back Pain
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT04874636's enrollment target sits among peer trials
153 23rd of 71 higher than 49 of 71 other Chronic Low Back Pain trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Chronic Low Back Pain trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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Ketamine-assisted Integrative Treatment for Veterans With Chronic Low Back Pain and Comorbid Depression
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Project 1 Aim 2, Adaptations of the Brain in Chronic Pain With Opioid Exposure
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Low-Dose Naltrexone and Acetaminophen Combination in the Treatment of Chronic Low Back Pain (ANODYNE-4)
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Chronic Low Back Pain Research Project
COMPLETED · Phase 2
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