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NCT06025201 · ClinicalTrials.gov registry record · NA
Detection of EEG-Based Biomarkers of Chronic Low Back Pain
A NA study of Healthy and Chronic Low Back Pain, sponsored by Stanford University.
- Recruiting
- Registry status
- NA
- Development phase
- 130
- Enrollment target
- 1
- Study location
NCT06025201: Recruiting NA study of Healthy and Chronic Low Back Pain, sponsored by Stanford University.
NCT06025201 is a NA study of Healthy and Chronic Low Back Pain that is actively recruiting participants, run by Stanford University. The registered enrollment target is 130 participants, below the 647-participant average among 1,090 other Healthy trials with a reported enrollment target (80% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06025201, a NA study of Healthy and Chronic Low Back Pain, is actively recruiting participants, sponsored by Stanford University.
- RECRUITING
- Registry status
- NA
- Development phase
- 130 participants
- Enrollment target
- 1
- Study location
Study Summary
Chronic low back pain (CLBP) is a pervasive disorder affecting up to one-fifth of adults globally and is the single greatest cause of disability worldwide. Despite the high prevalence and detrimental impact of CLBP, its treatments and mechanisms remain largely unclear. Biomarkers that predict symptom progression in CLBP support precision-based treatments and ultimately aid in reducing suffering. Longitudinal brain-based resting-state neuroimaging of patients with CLBP has revealed neural networks that predict pain chronification and its symptom progression. Although early findings suggest that measurements of brain networks can lead to the development of prognostic biomarkers, the predictive ability of these models is strongest for short-term follow-up. Measurements of different neural systems may provide additional benefits with better predictive power. Emotional and cognitive dysfunction is common in CLBP, occurring at the behavioral and cerebral level, presenting a unique opportunity to detect prognostic brain-based biomarkers. Likewise, improvements in electroencephalogram (EEG) neuroimaging strategies have led to increased spatial resolution, enabling researchers to overcome the limitations of classically used neuroimaging modalities (e.g., magnetic resonance imaging \[MRI\] and functional MRI), such as high cost and limited accessibility. Using longitudinal EEG, this patient-oriented research project will provide a comprehensive neural picture of emotional, cognitive, and resting-state networks in patients with CLBP, which will aid in predicting symptom progression in CLBP. Through this award, the investigators will use modern EEG source analysis strategies to track biomarkers at baseline and 1- and 2-month follow-ups and their covariance with markers for pain and emotional and cognitive dysfunction. A 5-month follow up will also be used to only assess patient reported outcomes. In Aim 1, the investigators will identify and characterize differences in resting
Primary Outcome
Within subjects change in pain intensity from baseline to each follow up point. Pain intensity measures are 0-10 range with larger numbers indicating more pain
Conditions Studied
Interventions
- BEHAVIORAL Resting State EEG
- BEHAVIORAL Picture Viewing EEG
- BEHAVIORAL Stop Signal EEG
Study Locations (1)
California
- Stanford's Systems and Neuroscience Pain Lab - Palo Alto
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 130 participants |
| Start Date | 2023-12-15 |
| Est. Completion | 2028-08 |
| Phase | NA |
What NCT06025201 shows while recruiting
NCT06025201 is an interventional study that assigns participants to a tested intervention. The registered 130 participants enrollment target is mid-sized for trials with a published cap, below the 647-participant average among 1,090 other Healthy trials with a reported enrollment target (80% lower).
The record links to 2 conditions, with Healthy appearing as the primary indexed condition, and to 3 interventions - of which Resting State EEG is the first listed.
NCT06025201 reports a single indexed study location in California.
Frequently Asked Questions
What is clinical trial NCT06025201 about?
NCT06025201 is a clinical study titled "Detection of EEG-Based Biomarkers of Chronic Low Back Pain". Chronic low back pain (CLBP) is a pervasive disorder affecting up to one-fifth of adults globally and is the single greatest cause of disability worldwide. Despite the high prevalence and detrimental impact of CLBP, its treatments and mechanisms remain largely unclear. Biomarkers that predict sympto...
What is the current status of trial NCT06025201?
This trial is currently recruiting. It is a NA study. The enrollment target is 130 participants. The study started on 2023-12-15. Estimated completion is 2028-08.
What conditions does trial NCT06025201 study?
This clinical trial studies the following conditions: Healthy, Chronic Low Back Pain.
What interventions are being tested in trial NCT06025201?
The interventions under investigation include: Resting State EEG (BEHAVIORAL), Picture Viewing EEG (BEHAVIORAL), Stop Signal EEG (BEHAVIORAL).
Who is sponsoring clinical trial NCT06025201?
This trial is sponsored by Stanford University, which has 1,744 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06025201 being conducted?
This trial has 1 study location across California. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Healthy
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT06025201's enrollment target sits among peer trials
130 172nd of 1090 higher than 918 of 1,090 other Healthy trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Healthy trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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