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ClinicalTrials.gov 30 recruiting now official registry

Chronic Low Back Pain clinical trials

30 of 72 indexed Chronic Low Back Pain trials are currently recruiting.

72 US clinical trials · 30 currently recruiting

Chronic Low Back Pain is the subject of 72 registered US clinical trials on ClinicalTrials.gov, 30 of them currently open to new participants. 5 are in Phase 3-4 (later-stage) and 15 in Phase 1-2 (earlier-stage). The most active sponsor is VA Office of Research and Development, running 6 of these trials.

The research picture

Chronic Low Back Pain has 72 registered US clinical trials, 30 of them open to new participants right now, about 42% of the total.

30
recruiting participants now
42%
of trials open to enrollment
5
in Phase 3–4 (later-stage)
6
top sponsor: VA Office of Research and Development
Phase 16Phase 29Phase 31Phase 44

Active & Recent Trials

72 total, page 2 of 2

COMPLETED 124 participants

Ultrasound Imaging for Myofascial Pain

University of Pittsburgh

NCT05928884

COMPLETED NA 120 participants

Mindfulness and Chronic Low Back Pain

University of California, San Diego

NCT03354585

COMPLETED 113 participants

MIS MiLIF Versus Open

Zimmer Biomet

NCT00792129

COMPLETED Phase 2 108 participants

Chronic Low Back Pain Research Project

US Department of Veterans Affairs

NCT00108550

COMPLETED Phase 4 102 participants

Pilot Study of the Efficacy and Safety of Lidoderm Patch in the Treatment of Low Back Pain

Endo Pharmaceuticals

NCT00904475

COMPLETED NA 79 participants

Brain Mechanisms of Acupuncture Treatment in Chronic Low Back Pain

Brigham and Women's Hospital

NCT01595451

COMPLETED NA 67 participants

Telehealth Mindfulness After Spine Surgery

Vanderbilt University Medical Center

NCT05698914

COMPLETED NA 55 participants

Making Better Lives: Patient-Focused Care for Low Back Pain (LBP)

VA Office of Research and Development

NCT02697435

COMPLETED NA 48 participants

Battlefield Acupuncture for Low Back Pain

The Geneva Foundation

NCT03491124

COMPLETED 43 participants

Correlation of Trust and Outcomes Following Physical Therapy for Chronic Low Back Pain

University of South Dakota

NCT03443401

COMPLETED Phase 1 43 participants

Study of PIPE-791 for Subjects With Chronic Osteoarthritis Pain or Chronic Low Back Pain

Contineum Therapeutics

NCT06810245

COMPLETED NA 42 participants

Meditation and Exercise to Treat Chronic Back Pain

Duquesne University

NCT03324659

COMPLETED NA 40 participants

Effects of Spinal Stabilization Exercises on Dynamic Balance and Functional Performance in Adults With Low Back Pain

Texas Woman's University

NCT03597191

COMPLETED 39 participants

Methylglyoxal Evaluation in Humans

University of Kansas Medical Center

NCT05350553

COMPLETED Phase 4 36 participants

Determining the Prognostic Value of Continuous Intrathecal Infusion

University Hospitals Cleveland Medical Center

NCT03523000

COMPLETED NA 34 participants

Self-Management of Chronic Low Back Pain: Targeting Patient Activation

Johns Hopkins University

NCT06236529

COMPLETED NA 32 participants

Yoga and Mantram for Chronic Pain and PTSD

VA Office of Research and Development

NCT03816007

COMPLETED NA 31 participants

Virtual Reality Guided Acupuncture Imagery Treatment for Chronic Low Back Pain

Massachusetts General Hospital

NCT06814470

COMPLETED NA 30 participants

Research Study on Patient Education for People With Chronic Low Back Pain

University of Pittsburgh

NCT06492642

COMPLETED NA 20 participants

MEPS-Pain: Personalized Pain Self-management Planning by and for Veterans Pilot Study

VA Office of Research and Development

NCT04075487

COMPLETED NA 15 participants

Vertical Climbing (CLMBR) Exercise for Chronic Low Back Pain

Icahn School of Medicine at Mount Sinai

NCT05483608

COMPLETED Phase 2 12 participants

Low-Dose Naltrexone and Acetaminophen Combination in the Treatment of Chronic Low Back Pain (ANODYNE-4)

Allodynic Therapeutics

NCT03201393

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Phase Distribution

PhaseTrial count
Phase 1 6
Phase 2 9
Phase 3 1
Phase 4 4

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Chronic Low Back Pain Trial Landscape

72 indexed Chronic Low Back Pain studies · 30 recruiting (42%).

Phase mix: 5 late (III/IV) vs 15 early (I/II).

Top sponsor: VA Office of Research and Development (6 trials), 9 others listed. 22 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Chronic Low Back Pain?

PlainTrial tracks 72 US clinical trials for Chronic Low Back Pain, of which 30 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Chronic Low Back Pain?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.