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Chronic Low Back Pain clinical trials
30 of 72 indexed Chronic Low Back Pain trials are currently recruiting.
72 US clinical trials · 30 currently recruiting
Chronic Low Back Pain is the subject of 72 registered US clinical trials on ClinicalTrials.gov, 30 of them currently open to new participants. 5 are in Phase 3-4 (later-stage) and 15 in Phase 1-2 (earlier-stage). The most active sponsor is VA Office of Research and Development, running 6 of these trials.
The research picture
Chronic Low Back Pain has 72 registered US clinical trials, 30 of them open to new participants right now, about 42% of the total.
- 30
- recruiting participants now
- 42%
- of trials open to enrollment
- 5
- in Phase 3–4 (later-stage)
- 6
- top sponsor: VA Office of Research and Development
Active & Recent Trials
72 total, page 2 of 2
Ultrasound Imaging for Myofascial Pain
University of Pittsburgh
NCT05928884
Mindfulness and Chronic Low Back Pain
University of California, San Diego
NCT03354585
MIS MiLIF Versus Open
Zimmer Biomet
NCT00792129
Chronic Low Back Pain Research Project
US Department of Veterans Affairs
NCT00108550
Pilot Study of the Efficacy and Safety of Lidoderm Patch in the Treatment of Low Back Pain
Endo Pharmaceuticals
NCT00904475
Brain Mechanisms of Acupuncture Treatment in Chronic Low Back Pain
Brigham and Women's Hospital
NCT01595451
Telehealth Mindfulness After Spine Surgery
Vanderbilt University Medical Center
NCT05698914
Making Better Lives: Patient-Focused Care for Low Back Pain (LBP)
VA Office of Research and Development
NCT02697435
Battlefield Acupuncture for Low Back Pain
The Geneva Foundation
NCT03491124
Correlation of Trust and Outcomes Following Physical Therapy for Chronic Low Back Pain
University of South Dakota
NCT03443401
Study of PIPE-791 for Subjects With Chronic Osteoarthritis Pain or Chronic Low Back Pain
Contineum Therapeutics
NCT06810245
Meditation and Exercise to Treat Chronic Back Pain
Duquesne University
NCT03324659
Effects of Spinal Stabilization Exercises on Dynamic Balance and Functional Performance in Adults With Low Back Pain
Texas Woman's University
NCT03597191
Methylglyoxal Evaluation in Humans
University of Kansas Medical Center
NCT05350553
Determining the Prognostic Value of Continuous Intrathecal Infusion
University Hospitals Cleveland Medical Center
NCT03523000
Self-Management of Chronic Low Back Pain: Targeting Patient Activation
Johns Hopkins University
NCT06236529
Yoga and Mantram for Chronic Pain and PTSD
VA Office of Research and Development
NCT03816007
Virtual Reality Guided Acupuncture Imagery Treatment for Chronic Low Back Pain
Massachusetts General Hospital
NCT06814470
Research Study on Patient Education for People With Chronic Low Back Pain
University of Pittsburgh
NCT06492642
MEPS-Pain: Personalized Pain Self-management Planning by and for Veterans Pilot Study
VA Office of Research and Development
NCT04075487
Vertical Climbing (CLMBR) Exercise for Chronic Low Back Pain
Icahn School of Medicine at Mount Sinai
NCT05483608
Low-Dose Naltrexone and Acetaminophen Combination in the Treatment of Chronic Low Back Pain (ANODYNE-4)
Allodynic Therapeutics
NCT03201393
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 6 |
| Phase 2 | 9 |
| Phase 3 | 1 |
| Phase 4 | 4 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Chronic Low Back Pain Trial Landscape
72 indexed Chronic Low Back Pain studies · 30 recruiting (42%).
Phase mix: 5 late (III/IV) vs 15 early (I/II).
Top sponsor: VA Office of Research and Development (6 trials), 9 others listed. 22 shown below, recruiting first.
How to read this condition's trial landscape
That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Chronic Low Back Pain?
PlainTrial tracks 72 US clinical trials for Chronic Low Back Pain, of which 30 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Chronic Low Back Pain?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology - how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.