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ClinicalTrials.gov 36 recruiting now official registry

Cholangiocarcinoma clinical trials

Every US clinical trial registered for Cholangiocarcinoma — phase mix, recruiting status, and the sponsors running them, straight from the NIH ClinicalTrials.gov registry.

61 US clinical trials · 36 currently recruiting

The research picture

Cholangiocarcinoma has 61 registered US clinical trials, 36 of them open to new participants right now — about 59% of the total.

36
recruiting participants now
59%
of trials open to enrollment
3
in Phase 3–4 (later-stage)
6
top sponsor: National Cancer Institute (NCI)

Counts reflect the public ClinicalTrials.gov registry as last mirrored by PlainTrial. Status and phase are reported by each study's sponsor. This is reference information, not medical advice.

Active & Recent Trials

RECRUITING 9,150 participants

Biobank for Cholestatic Liver Diseases.

Mayo Clinic

NCT03445585

RECRUITING 1,800 participants

Obtaining Solid Tumor Tissue From People Having Biopsy or Surgery for Certain Types of Cancer

National Cancer Institute (NCI)

NCT01915225

RECRUITING 1,500 participants

Molecular Epidemiology of Biliary Tree Cancers

M.D. Anderson Cancer Center

NCT05179486

RECRUITING 1,000 participants

A Noninvasive and Screening miRNA Signature for Gastrointestinal Cancer

City of Hope Medical Center

NCT07224750

RECRUITING NA 990 participants

Washington University Participant Engagement and Cancer Genomic Sequencing Center (WU-PE-CGS)

Washington University School of Medicine

NCT06340646

RECRUITING NA 845 participants

High Volume Washing of the Abdomen in Increasing Survival After Surgery in Patients With Pancreatic Cancer That Can Be Removed by Surgery

Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University

NCT02757859

RECRUITING 500 participants

National Translational Science Network of Precision-based Immunotherapy for Primary Liver Cancer

National Cancer Institute (NCI)

NCT04145141

RECRUITING 500 participants

Frequency and Clinical Phenotype of BAP1 Hereditary Predisposition Syndrome

Mohamed Abdel-Rahman

NCT04792463

RECRUITING 400 participants

An Exosome-Based Liquid Biopsy for the Differential Diagnosis of Primary Liver Cancer

City of Hope Medical Center

NCT06342414

RECRUITING NA 400 participants

TCF-001 TRACK (Target Rare Cancer Knowledge) Study

TargetCancer Foundation

NCT04504604

RECRUITING NA 358 participants

The Dragon PLC Trial (DRAGON-PLC)

Maastricht University

NCT06914648

RECRUITING Phase 2 320 participants

18F-Fibroblast Activation Protein Inhibitor ([18F]FAPI-74) PET Imaging for Cancer Detection

National Cancer Institute (NCI)

NCT06503146

RECRUITING 300 participants

Characterization of Biliary Cell-derived Organoids From Bile of PSC and Non-PSC Patients

Mayo Clinic

NCT04753996

RECRUITING Phase 1 241 participants

A Study of LY4337713 in Participants With FAP-Positive Solid Tumors

Eli Lilly and Company

NCT07213791

RECRUITING NA 240 participants

Implementing a Randomized Control Trial to Test the Expanded Web-based Decision Aid

Washington University School of Medicine

NCT06910670

RECRUITING Phase 1 220 participants

BOLD-100 in Combination With FOLFOX for the Treatment of Advanced Solid Tumours

Bold Therapeutics

NCT04421820

RECRUITING Phase 3 200 participants

Study of Tinengotinib VS. Physician's Choice a Treatment of Subjects With FGFR-altered in Cholangiocarcinoma

TransThera Sciences (Nanjing)

NCT05948475

RECRUITING Phase 1 124 participants

A Study of MGC028 in Participants With Advanced Solid Tumors

MacroGenics

NCT06723236

RECRUITING Phase 1 110 participants

A Study of an FGFR2/3 Inhibitor (CGT4859) in Patients With Cholangiocarcinoma and Other Advanced Solid Tumors

Cogent Biosciences

NCT06777316

RECRUITING Phase 1 110 participants

18F-FSPG PET in Imaging Patients With Liver Cancer Before Undergoing Surgery or Transplant

M.D. Anderson Cancer Center

NCT02379377

RECRUITING NA 100 participants

Targeted Navigation in Hepatocellular Carcinoma (HCC)

University of Miami

NCT06260943

RECRUITING Phase 1 100 participants

A Study to Investigate APL-5125 in Adults With Advanced Solid Tumors

Apollo Therapeutics

NCT06399757

RECRUITING Phase 1 74 participants

Combination of GNS561 and Trametinib in Patients With Advanced KRAS Mutated Cholangiocarcinoma

Genfit

NCT05874414

RECRUITING Phase 2 70 participants

PDS01ADC in Combination With Hepatic Artery Infusion Pump (HAIP) and Systemic Therapy for Subjects With Metastatic Colorectal Cancer, Intrahepatic Cholangiocarcinoma, or Metastatic Adrenocortical Carcinoma

National Cancer Institute (NCI)

NCT05286814

RECRUITING Phase 1 70 participants

Pemigatinib + Afatinib in Advanced Refractory Solid Tumors

Massachusetts General Hospital

NCT06302621

RECRUITING Phase 2 59 participants

Adoptive Transfer of Tumor Infiltrating Lymphocytes for Biliary Tract Cancers

Udai Kammula

NCT03801083

RECRUITING NA 40 participants

HepQuant: Study to Assess the Role of Blood-based Biomarkers and Quantitative MR Imaging for Patients Receiving Radiation Therapy for Liver Cancer

Montefiore Medical Center

NCT06899152

RECRUITING Phase 2 33 participants

Study of Gemcitabine, Cisplatin, AB680 and AB122 During First Line Treatment of Advanced Biliary Tract Cancers (QUIC)

Nataliya Uboha

NCT06048133

RECRUITING Phase 1 31 participants

Evaluating Efficacy of Tivozanib (AV-951) in Biliary Tract Cancers

National Cancer Institute (NCI)

NCT04645160

RECRUITING Phase 1 30 participants

Determining the Biodistribution of an Imaging Tracer (68Ga-FAPi-46) in Patients With Solid Tumors or Hematologic Cancers

Jonsson Comprehensive Cancer Center

NCT07118176

RECRUITING Phase 2 30 participants

Y-90 With Durvalumab/Gem/Cis in Intrahepatic Cholangio

Beth Israel Deaconess Medical Center

NCT05655949

RECRUITING Phase 2 27 participants

Trifluridine/Tipiracil + Oxaliplatin in Participants With Advanced or Metastatic Biliary Tract Cancer

Case Comprehensive Cancer Center

NCT07146646

RECRUITING Phase 2 24 participants

A Single-Arm Study of Pembrolizumab With Gemcitabine and Cisplatin as Perioperative Therapy for Potentially Resectable Intrahepatic Cholangiocarcinoma

M.D. Anderson Cancer Center

NCT05967182

RECRUITING Phase 4 16 participants

Olutasidenib DDI Study in Patients With IDH1 Mutation Positive Malignancies

Rigel Pharmaceuticals

NCT07486713

RECRUITING NA 15 participants

Pilot Comparing ctDNA IDV vs. SPV Sample in Pts Undergoing Biopsies for Hepatobiliary and Pancreatic Cancers

University of California, Irvine

NCT05497531

RECRUITING Phase 1 15 participants

Chemoimmunotherapy Combined With Hyperthermia and Spatially-Fractionated Radiotherapy in Advanced Biliary Tract Cancer

University of Maryland, Baltimore

NCT06546969

ACTIVE NOT RECRUITING Phase 2 534 participants

Basket Study of Entrectinib (RXDX-101) for the Treatment of Patients With Solid Tumors Harboring NTRK 1/2/3 (Trk A/B/C), ROS1, or ALK Gene Rearrangements (Fusions)

Hoffmann-La Roche

NCT02568267

ACTIVE NOT RECRUITING Phase 1 200 participants

Study of LY3410738 Administered to Patients With Advanced Solid Tumors With IDH1 or IDH2 Mutations

Eli Lilly and Company

NCT04521686

ACTIVE NOT RECRUITING Phase 1 179 participants

Study of NGM707 As Monotherapy and in Combination with Pembrolizumab in Advanced or Metastatic Solid Tumor Malignancies

NGM Biopharmaceuticals

NCT04913337

ACTIVE NOT RECRUITING Phase 2 150 participants

A Study of CTX-009 in Combination With Paclitaxel in Adult Patients With Unresectable Advanced, Metastatic or Recurrent Biliary Tract Cancers (COMPANION-002)

Compass Therapeutics

NCT05506943

ACTIVE NOT RECRUITING Phase 1 138 participants

A Study of TRK-950 in Combinations With Anti-Cancer Treatment Regimens in Patients With Advanced Solid Tumors

Toray Industries

NCT03872947

ACTIVE NOT RECRUITING Phase 2 67 participants

A Study of LSTA1 When Added to Standard of Care Versus Standard of Care Alone in Patients With Advanced Solid Tumors

Lisata Therapeutics

NCT05712356

ACTIVE NOT RECRUITING Phase 2 58 participants

Domvanalimab and Zimberelimab in Advanced Liver Cancers

University of Texas Southwestern Medical Center

NCT05724563

ACTIVE NOT RECRUITING Phase 1 57 participants

Phase 1/2 Trial of Gavo-cel (TC-210) in Patients With Advanced Mesothelin-Expressing Cancer

TCR2 Therapeutics

NCT03907852

ACTIVE NOT RECRUITING Phase 2 40 participants

Tucatinib Plus Trastuzumab and Oxaliplatin-based Chemotherapy or Pembrolizumab-containing Combinations for HER2+ Gastrointestinal Cancers

Seagen, a wholly owned subsidiary of Pfizer

NCT04430738

ACTIVE NOT RECRUITING Phase 1 36 participants

Radiation Therapy in Treating Patients With Hepatocellular Carcinoma, Cholangiocarcinoma, or Liver Metastasis Who Have Impaired Liver Function

M.D. Anderson Cancer Center

NCT02626312

ACTIVE NOT RECRUITING Phase 1 26 participants

Prospective Exploratory Study of FAPi PET/CT With Histopathology Validation in Patients With Various Cancers

Jonsson Comprehensive Cancer Center

NCT04459273

ACTIVE NOT RECRUITING NA 25 participants

Senior Adult Hepatobiliary Prehab Study

H. Lee Moffitt Cancer Center and Research Institute

NCT05921552

COMPLETED Phase 1 490 participants

REFOCUS: A First-in-Human Study of Highly Selective FGFR2 Inhibitor, RLY-4008, in Patients With ICC and Other Advanced Solid Tumors

Elevar Therapeutics

NCT04526106

COMPLETED 230 participants

Detecting Lymph Node Metastasis in Intrahepatic Cholangiocarcinoma (LyMIC)

City of Hope Medical Center

NCT06381648

COMPLETED 183 participants

EchoTip AcuCore Post-Market Clinical Study

Cook Research Incorporated

NCT06358001

COMPLETED Phase 3 161 participants

Evaluating Length of Treatment With PD-1/PD-L1 Inhibitor in Advanced Solid Tumors

Dan Zandberg

NCT04157985

COMPLETED Phase 2 147 participants

Efficacy and Safety of Pemigatinib in Subjects With Advanced/Metastatic or Surgically Unresectable Cholangiocarcinoma Who Failed Previous Therapy - (FIGHT-202)

Incyte Corporation

NCT02924376

COMPLETED Phase 1 127 participants

Study of CX-4945 in Combination With Gemcitabine and Cisplatin for Frontline Treatment of Cholangiocarcinoma

Senhwa Biosciences

NCT02128282

COMPLETED Phase 2 65 participants

A Study of ABC294640 Alone and in Combination With HCQ Sulfate in the Treatment of Advanced Cholangiocarcinoma

RedHill Biopharma Limited

NCT03377179

COMPLETED Phase 2 61 participants

Ramucirumab in Treating Patients With Advanced or Metastatic, Previously Treated Biliary Cancers That Cannot Be Removed by Surgery

M.D. Anderson Cancer Center

NCT02520141

COMPLETED Phase 1 38 participants

TPST-1120 as Monotherapy and in Combination With Nivolumab in Subjects With Advanced Cancers

Tempest Therapeutics

NCT03829436

COMPLETED Phase 2 37 participants

A Trial of Niraparib in BAP1 and Other DNA Damage Response (DDR) Deficient Neoplasms (UF-STO-ETI-001)

University of Florida

NCT03207347

COMPLETED Phase 2 35 participants

A Study of the Use of the Medtronic Pump and Codman Catheter to Give Chemotherapy to Patients With Colorectal Carcinoma or Cholangiocarcinoma

Memorial Sloan Kettering Cancer Center

NCT03693807

COMPLETED NA 15 participants

A Pilot Study to Assess Theragnostically Planned Liver Radiation to Optimize Radiation Therapy

Indiana University

NCT03338062

COMPLETED Phase 2 10 participants

Perioperative MVT-5873, a Fully Human Monoclonal Antibody Against a CA 19-9 Epitope, for Operable CA 19-9 Producing Pancreatic Cancers, Cholangiocarcinomas, and Metastatic Colorectal Cancers

National Cancer Institute (NCI)

NCT03801915

Phase Distribution

PhaseTrial count
Phase 1 20
Phase 2 18
Phase 3 2
Phase 4 1

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Cholangiocarcinoma Trial Landscape

ClinicalTrials.gov lists 61 US studies indexed under Cholangiocarcinoma, and 36 of those are currently open to recruitment — roughly 59% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

The phase distribution for Cholangiocarcinoma shows 3 late-stage studies (Phase 3 and Phase 4 combined) alongside 38 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

Top sponsor activity for Cholangiocarcinoma is led by National Cancer Institute (NCI) with 6 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 61 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Cholangiocarcinoma?

PlainTrial tracks 61 US clinical trials for Cholangiocarcinoma, of which 36 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Cholangiocarcinoma?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Related

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

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