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ClinicalTrials.gov 21 recruiting now official registry

Malignant Neoplasm clinical trials

Every US clinical trial registered for Malignant Neoplasm — phase mix, recruiting status, and the sponsors running them, straight from the NIH ClinicalTrials.gov registry.

61 US clinical trials · 21 currently recruiting

The research picture

Malignant Neoplasm has 61 registered US clinical trials, 21 of them open to new participants right now — about 34% of the total.

21
recruiting participants now
34%
of trials open to enrollment
4
in Phase 3–4 (later-stage)
14
top sponsor: M.D. Anderson Cancer Center

Counts reflect the public ClinicalTrials.gov registry as last mirrored by PlainTrial. Status and phase are reported by each study's sponsor. This is reference information, not medical advice.

Active & Recent Trials

RECRUITING 999,999 participants

Molecular Genetics Studies of Cancer Patients and Their Relatives

City of Hope Medical Center

NCT04185935

RECRUITING 10,000 participants

Norris ORIEN Total Cancer Care

University of Southern California

NCT02970045

RECRUITING 6,500 participants

New Assessment System in Measuring Symptom Distress in Cancer Patients

M.D. Anderson Cancer Center

NCT00505245

RECRUITING 2,000 participants

Germ-Line Mutations in Blood and Saliva Samples From Patients With Cancer

Jonsson Comprehensive Cancer Center

NCT02280161

RECRUITING 1,100 participants

Targeted Genomic Analysis of Blood and Tissue Samples From Patients With Cancer

Rutgers, The State University of New Jersey

NCT02688517

RECRUITING NA 1,001 participants

Engagement of American Indians of Southwestern Tribal Nations in Cancer Genome Sequencing

New Mexico Cancer Research Alliance

NCT06207864

RECRUITING NA 590 participants

Association Between Health Care Provider (HCP)-Assessed ECOG Performance Status (PS) and Overall Survival, and Objectively Measure of Physical Activity (PA) Levels in Advance-cancer Patients"

M.D. Anderson Cancer Center

NCT01365169

RECRUITING 500 participants

Collection of Immunology Specimens From Patients With Cancer or Blood Disorders, and Healthy Volunteers

University of Southern California

NCT03207854

RECRUITING Phase 1 440 participants

A Study of TSN1611 Treating Patients With Advanced Solid Tumors Harboring KRAS G12D Mutation

Tyligand Pharmaceuticals (Suzhou) Limited

NCT06385925

RECRUITING Phase 1 270 participants

A Study to Evaluate the Safety and Efficacy of MK-3120 in Participants With Advanced Solid Tumors (MK-3120-002)

Merck Sharp & Dohme

NCT06818643

RECRUITING Phase 1 250 participants

A Clinical Study of MK-4716 in People With Certain Solid Tumors (MK-4716-001)

Merck Sharp & Dohme

NCT07247110

RECRUITING Phase 2 250 participants

A Study of MK-5684 in People With Certain Solid Tumors (MK-5684-015/OMAHA-015)

Merck Sharp & Dohme

NCT06979596

RECRUITING Phase 3 180 participants

Pre-operative SRS or Post-operative SRS in Treating Cancer Patients With Brain Metastases

M.D. Anderson Cancer Center

NCT03741673

RECRUITING NA 180 participants

Novel Outreach Methods to Increase Enrollment to Early Phase Clinical Trials

University of Chicago

NCT05886764

RECRUITING Phase 1 168 participants

A Study of OR502, a Monoclonal Antibody Targeting LILRB2, Alone and in Combination With Anticancer Agents

OncoResponse

NCT06090266

RECRUITING Phase 2 130 participants

KEYMAKER-U01 Substudy 01J: A Study of Pembrolizumab Plus MK-1084 in Participants With Non-Small Cell Lung Cancer (NSCLC) With Kirsten Rat Sarcoma Viral Oncogene Homolog (KRAS) G12C Mutations (MK-3475-01J/KEYMAKER-U01J)

Merck Sharp & Dohme

NCT07252739

RECRUITING Phase 2 100 participants

Cytotoxic T Lymphocytes in Treating Patients With Malignancies With BK and/or JC Virus

M.D. Anderson Cancer Center

NCT02479698

RECRUITING Phase 2 100 participants

Intraoperative Tumor Margin Identification With ICG Dye Imaging

Massachusetts General Hospital

NCT04752137

RECRUITING NA 70 participants

Decreasing Chemotherapy Induced Distress Using Immersive Virtual Reality in Patients With Cancer

Case Comprehensive Cancer Center

NCT06446115

RECRUITING Phase 1 50 participants

A Study of Patritumab Deruxtecan in Pediatric Participants With Relapsed or Refractory Solid Tumors (MK-9999-01C/LIGHTBEAM-U01)

Merck Sharp & Dohme

NCT06941272

RECRUITING NA 20 participants

A Study to See if an iPhone Weight Management App Can Help Promote Weight Loss in Adolescents and Young Adults After a Stem Cell Transplant

Jonsson Comprehensive Cancer Center

NCT04453072

ACTIVE NOT RECRUITING NA 434 participants

Reproductive Health Program in Patients With Cancer

ECOG-ACRIN Cancer Research Group

NCT01806129

ACTIVE NOT RECRUITING NA 325 participants

Use of a Pre-Surgical Toolkit in Improving Surgical Care and Outcomes in Older Participants With Cancer

Alliance for Clinical Trials in Oncology

NCT03857620

ACTIVE NOT RECRUITING 170 participants

Molecular Profiling in Tissue Samples From Patients With Cancer Who Are Exceptional Responders to Treatment

National Cancer Institute (NCI)

NCT02243592

ACTIVE NOT RECRUITING 160 participants

Novel Single Wave Assessment in Measuring Cardiac Dysfunction and Metabolic Syndrome in Patients With Cancer

City of Hope Medical Center

NCT04014231

ACTIVE NOT RECRUITING Phase 1 155 participants

Bevacizumab and Temsirolimus Alone or in Combination With Valproic Acid or Cetuximab in Treating Patients With Advanced or Metastatic Malignancy or Other Benign Disease

M.D. Anderson Cancer Center

NCT01552434

ACTIVE NOT RECRUITING Phase 2 135 participants

Dexamethasone in Controlling Dyspnea in Patients With Cancer

M.D. Anderson Cancer Center

NCT03367156

ACTIVE NOT RECRUITING 72 participants

Blood Samples to Identify Biomarkers in Patients Treated With Cyclophosphamide After Donor Stem Cell Transplant

City of Hope Medical Center

NCT04160390

ACTIVE NOT RECRUITING NA 56 participants

rTMS in Improving Neuropathy in Patients With Stage I-IV Cancer Who Have Received Oxaliplatin Chemotherapy

M.D. Anderson Cancer Center

NCT03219502

ACTIVE NOT RECRUITING NA 35 participants

Meditation Therapy in Improving Anxiety and Depression in Cancer Patients With Psychosocial Distress

M.D. Anderson Cancer Center

NCT02988271

ACTIVE NOT RECRUITING NA 28 participants

Measuring Changes in Body Composition and Physical Function in Patients With Childhood Cancers

UNC Lineberger Comprehensive Cancer Center

NCT05823740

ACTIVE NOT RECRUITING Phase 1 24 participants

HER2-CAR T Cells in Treating Patients With Recurrent Brain or Leptomeningeal Metastases

City of Hope Medical Center

NCT03696030

ACTIVE NOT RECRUITING 10 participants

Web-Based Family Outreach Program for Cancer Prevention in High-Risk Families

M.D. Anderson Cancer Center

NCT02337452

ACTIVE NOT RECRUITING Phase 2 6 participants

Gene and Vaccine Therapy in Treating Patients With Advanced Malignancies

Jonsson Comprehensive Cancer Center

NCT01697527

COMPLETED NA 1,000 participants

Music in Reducing Distress in Participants with Cancer During Chemotherapy Treatment

Barbara Ann Karmanos Cancer Institute

NCT03683420

COMPLETED NA 746 participants

Yoga, Survivorship Health Education, and Cognitive Behavioral Therapy in Reducing Insomnia in Cancer Survivors

University of Rochester NCORP Research Base

NCT02613364

COMPLETED Phase 3 690 participants

Olanzapine With or Without Fosaprepitant Dimeglumine in Preventing Chemotherapy Induced Nausea and Vomiting in Cancer Patients Receiving Highly Emetogenic Chemotherapy

Alliance for Clinical Trials in Oncology

NCT03578081

COMPLETED NA 418 participants

Multimedia Psychoeducation or Print Education in Preparing Cancer Patients for Decision Making About Clinical Trials

Gary Morrow

NCT02054715

COMPLETED NA 377 participants

Evidence-Based Tobacco Cessation Strategies in Patients With Cancer

Wake Forest University Health Sciences

NCT02211196

COMPLETED Phase 3 300 participants

Apixaban or Dalteparin in Reducing Blood Clots in Patients With Cancer Related Venous Thromboembolism

Academic and Community Cancer Research United

NCT02585713

COMPLETED NA 125 participants

Videos and Questionnaires in Assessing Patient Perception of Physician's Compassion, Communication Skills, and Professionalism During Clinic Visits

M.D. Anderson Cancer Center

NCT03856060

COMPLETED NA 124 participants

Music Therapy Video Development in Improving Communication, Emotional Distress, and Recovery in Adolescents/Young Adults Undergoing Treatment for High-Risk Cancer and Their Parents

Children's Oncology Group

NCT01556256

COMPLETED Phase 3 118 participants

Music Therapy or Book Discussion in Improving Quality of Life in Young Patients Undergoing Stem Cell Transplant

Children's Oncology Group

NCT00305851

COMPLETED 115 participants

A Survey of Parent/Caregiver Practices on the Storage, Use, and Disposal of Opioids in a Comprehensive Cancer Center

M.D. Anderson Cancer Center

NCT03390283

COMPLETED NA 102 participants

Palliative Radiation Therapy in Reducing Pain in Patients With Bone Metastasis

Wake Forest University Health Sciences

NCT02699697

COMPLETED 100 participants

Communication Effectiveness in Cancer Treatment

Wake Forest University Health Sciences

NCT02197091

COMPLETED NA 91 participants

Tailoring Patient Education to Perceived Risk for Falls in Hospitalized Oncology Patients

Case Comprehensive Cancer Center

NCT02081794

COMPLETED Phase 2 87 participants

Low-Dose Ibuprofen in Improving Cognitive Impairment in Patients With Cancer

University of Rochester NCORP Research Base

NCT03186638

COMPLETED 82 participants

Factors Affecting Patient Participation in AIDS Malignancy Clinical Trials Consortium Clinical Trials

AIDS Malignancy Consortium

NCT01946217

COMPLETED Phase 1 63 participants

Evaluation of Food Effect on Pharmacokinetics of Vismodegib

National Cancer Institute (NCI)

NCT01174264

COMPLETED Phase 2 53 participants

Netupitant and Palonosetron Hydrochloride in Preventing Chronic Nausea and Vomiting in Patients With Cancer

M.D. Anderson Cancer Center

NCT03040726

COMPLETED NA 41 participants

Meditative Slow Breathing or Isha Kriya Meditation in Improving Cancer-Related Symptoms in Hospitalized Participants With Cancer

M.D. Anderson Cancer Center

NCT03445572

COMPLETED NA 30 participants

Sensory Evaluation of Oral Nutrition Supplements in Patients at Risk for Mucositis Undergoing Cancer Treatment

Rutgers, The State University of New Jersey

NCT03228147

COMPLETED NA 22 participants

Psycho-Educational Program in Increasing Knowledge and Satisfaction and Decreasing Distress in Younger Patients With Cancer Receiving Treatment

City of Hope Medical Center

NCT01817335

COMPLETED NA 20 participants

A Computer-Based System for Symptom Reporting in Patients With Cancer Undergoing Treatment

Thomas Jefferson University

NCT03979846

COMPLETED NA 16 participants

Scrambler Therapy for the Reduction of Chemotherapy-Induced Neuropathic Pain

M.D. Anderson Cancer Center

NCT04239976

COMPLETED Phase 1 15 participants

Extended Use of Sodium Bicarbonate in Patients With Cancer

University of Arizona

NCT02531919

COMPLETED NA 14 participants

Bovine Lactoferrin Supplement in Improving Taste in Patients With Cancer Receiving Chemotherapy

Wake Forest University Health Sciences

NCT01941810

COMPLETED NA 12 participants

Short-Term Fasting Before Chemotherapy in Treating Patients With Cancer

Mayo Clinic

NCT01175837

COMPLETED NA 12 participants

SPECT/CT in Measuring Lung Function in Patients With Cancer Undergoing Radiation Therapy

University of Washington

NCT01982123

COMPLETED Phase 1 9 participants

Curcumin and Piperine in Reducing Inflammation for Ureteral Stent-Induced Symptoms in Patients With Cancer

Mayo Clinic

NCT02598726

Phase Distribution

PhaseTrial count
Phase 1 10
Phase 2 8
Phase 3 4

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Malignant Neoplasm Trial Landscape

ClinicalTrials.gov lists 61 US studies indexed under Malignant Neoplasm, and 21 of those are currently open to recruitment — roughly 34% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

The phase distribution for Malignant Neoplasm shows 4 late-stage studies (Phase 3 and Phase 4 combined) alongside 18 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

Top sponsor activity for Malignant Neoplasm is led by M.D. Anderson Cancer Center with 14 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 61 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Malignant Neoplasm?

PlainTrial tracks 61 US clinical trials for Malignant Neoplasm, of which 21 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Malignant Neoplasm?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Related

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

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