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ClinicalTrials.gov 28 recruiting now official registry

Depressive Symptoms clinical trials

28 of 61 indexed Depressive Symptoms trials are currently recruiting.

61 US clinical trials · 28 currently recruiting

Depressive Symptoms is the subject of 61 registered US clinical trials on ClinicalTrials.gov, 28 of them currently open to new participants. 1 are in Phase 3-4 (later-stage) and 5 in Phase 1-2 (earlier-stage). The most active sponsor is Johns Hopkins University, running 3 of these trials.

The research picture

Depressive Symptoms has 61 registered US clinical trials, 28 of them open to new participants right now, about 46% of the total.

28
recruiting participants now
46%
of trials open to enrollment
1
in Phase 3–4 (later-stage)
3
top sponsor: Johns Hopkins University
Phase 11Phase 24Phase 41

Active & Recent Trials

61 total, page 1 of 2

RECRUITING NA 6,516 participants

My Wellbeing Guide: a Novel Tool for Managing Stress and Improving Quality of Life

Northwestern University

NCT05369429

RECRUITING NA 326 participants

A Remotely Delivered Tai Chi/Qigong Intervention for Older People Living With HIV

Florida International University

NCT06586619

RECRUITING NA 300 participants

Cancer Pain Management Using a Web-based Intervention

University of Texas at Austin

NCT06085313

RECRUITING NA 300 participants

Our Voices Matter: Intervention for Depression in Youth

Ann & Robert H Lurie Children's Hospital of Chicago

NCT07216326

RECRUITING NA 279 participants

IMPACT (IMproving Proactive Approaches for Cancer Survivors' Mental Health Treatment)

Medical University of South Carolina

NCT06582784

RECRUITING NA 198 participants

rTMS for Military TBI-related Depression

Henry M. Jackson Foundation for the Advancement of Military Medicine

NCT05426967

RECRUITING NA 188 participants

Family Spirit Strengths

Johns Hopkins Bloomberg School of Public Health

NCT05836090

RECRUITING NA 180 participants

Benefits of Outdoor Walks in Reducing Depressive Symptoms

University of Washington

NCT06989801

RECRUITING NA 150 participants

A New Clinical Model for the Engagement of Latinx Youth With Suicidal Behavior

Bradley Hospital

NCT06882798

RECRUITING NA 150 participants

RXWell to Decrease Post-Operative Opioid Use in Total Knee or Hip Arthroplasty

University of Pittsburgh

NCT05658796

RECRUITING 150 participants

Reward Processing and Depressive Subtypes: Identifying Neural Biotypes

San Francisco Veterans Affairs Medical Center

NCT06080646

RECRUITING NA 140 participants

Strengthening Health and Insight in New Educators

University of Alabama, Tuscaloo

NCT06745934

RECRUITING NA 120 participants

Caregiver Stress and Sleep Study

University of Pittsburgh

NCT05219955

RECRUITING NA 120 participants

Survivorship Care for Women Living With Ovarian Cancer: (POSTCARE-O)

Baylor College of Medicine

NCT05752448

RECRUITING NA 110 participants

Video-feedback Intervention to Promote Racial-Ethnic Socialization Competency (VIP-RACE)

Penn State University

NCT07055906

RECRUITING NA 90 participants

Building Resilience for Surgical Recovery

The University of Texas Health Science Center, Houston

NCT06174701

RECRUITING NA 85 participants

Expressive Writing on Minority Stressors Among Sexual Minority Veterans

VA Office of Research and Development

NCT05897021

RECRUITING NA 80 participants

Michigan Men's Diabetes Project III(MenDIII): Mind and Motion

University of Michigan

NCT06574035

RECRUITING Phase 2 80 participants

Cannabidiol for Reduction of Brain Neuroinflammation

Massachusetts General Hospital

NCT05066308

RECRUITING NA 76 participants

Mood and Thought Process Study

Butler Hospital

NCT05585775

RECRUITING Phase 4 60 participants

Acute and Long-Term Antidepressant Treatment Success in Adolescents With Anxiety (AtLAS-A)

University of Cincinnati

NCT04245436

RECRUITING NA 60 participants

Mind-Body Skills Group for Graduate Students

Weill Medical College of Cornell University

NCT05447689

RECRUITING NA 60 participants

BTL-699-2 and HPM-6000UF Devices for the Improvement of Depressive Symptoms and Sexual Function Among Perimenopausal and Postmenopausal Women

BTL Industries

NCT07413705

RECRUITING NA 60 participants

BTL-699-2 and HPM-6000UF Devices for the Improvement of Depressive Symptoms and Urinary Incontinence in Postpartum and Early Post-Childbirth Women

BTL Industries

NCT07413692

RECRUITING NA 60 participants

Mobile CBT for Middle Aged and Older Adults

Weill Medical College of Cornell University

NCT05754151

RECRUITING NA 45 participants

Improving Mood for Adolescents Through Teaming With End-Users in Routine Care (The iMATTER Project)

Children's Hospital of Philadelphia

NCT07020572

RECRUITING NA 34 participants

VR-PMR for Post-Burn Symptoms

Johns Hopkins University

NCT07317271

RECRUITING Early Phase 1 20 participants

Psilocybin for Depression in People With Mild Cognitive Impairment or Early Alzheimer's Disease

Johns Hopkins University

NCT04123314

ACTIVE NOT RECRUITING 1,000 participants

Northern Manhattan Study of Metabolism and Mind

Columbia University

NCT02470260

ACTIVE NOT RECRUITING NA 475 participants

Evaluating a Virtual Mentoring Program Plus Mental Health Videos for Teens

Appa Health

NCT06138730

ACTIVE NOT RECRUITING NA 456 participants

A Trial of a Positive Psychology Intervention for Older Adults (RESET)

University of Michigan

NCT05451589

ACTIVE NOT RECRUITING NA 145 participants

Treatment for Migraine and Mood

Amanda Shallcross

NCT05576467

ACTIVE NOT RECRUITING NA 113 participants

Digital Therapeutic for Depression After Head Injury in Current and Former US Military Personnel

Henry M. Jackson Foundation for the Advancement of Military Medicine

NCT05147506

ACTIVE NOT RECRUITING NA 80 participants

Neurotechnology Following Traumatic Brain Injury

Brain State Technologies

NCT03649958

ACTIVE NOT RECRUITING NA 61 participants

Virtual Reality in Hemodialysis to Improve Psychological Well-being

University of Illinois at Urbana-Champaign

NCT05642364

ACTIVE NOT RECRUITING NA 30 participants

Pain Reduction Through Empowered Recovery (PRIME) Study

Johns Hopkins University

NCT05619510

ACTIVE NOT RECRUITING Phase 2 12 participants

Glutamatergic Modulation as a Treatment for Depressive Symptoms Among Patients With Post-acute Sequelae of COVID (PASC): A Pilot Trial

New York State Psychiatric Institute

NCT05690503

ACTIVE NOT RECRUITING NA 8 participants

Rare Group Problem Management Plus

Children's National Research Institute

NCT06548022

COMPLETED NA 655 participants

Brief Video Interventions for Depression

Ohio State University

NCT04643964

COMPLETED NA 449 participants

Evaluation of an Entrepreneurship Program for American-Indian Youth

Johns Hopkins Bloomberg School of Public Health

NCT02157493

COMPLETED NA 361 participants

An IT Approach to Implementing Depression Treatment in Cardiac Patients (iHeart DepCare)

Columbia University

NCT03882411

COMPLETED NA 350 participants

Guided Feedback in an Online Game Impacts Decision Making

Bard College

NCT05925816

COMPLETED NA 195 participants

Insomnia Self-Management in Heart Failure

Yale University

NCT02660385

COMPLETED NA 168 participants

Building Resiliency and Increasing Community Hope

University of California, Los Angeles

NCT01698047

COMPLETED Phase 2 132 participants

Study to Evaluate TNX-601 ER Monotherapy Versus Placebo in Patients With Major Depressive Disorder (MDD)

Tonix Pharmaceuticals

NCT05686408

COMPLETED NA 130 participants

Preventing Depression in People With Epilepsy: an Extension of Project UPLIFT

Emory University

NCT01941706

COMPLETED NA 120 participants

College Student Stress: Transitions Over Time

University of Michigan

NCT06583096

COMPLETED NA 102 participants

A Self-directed Mobile Mindfulness Intervention to Address Distress and Burnout in Frontline Healthcare Workers

Duke University

NCT04816708

COMPLETED NA 96 participants

Effects of a Single-session Implicit Theories of Personality Intervention on Early Adolescent Psychopathology

Harvard University

NCT03132298

COMPLETED NA 82 participants

Adapting Project UPLIFT for Blacks in Georgia

Morehouse School of Medicine

NCT02909387

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Phase Distribution

PhaseTrial count
Phase 1 1
Phase 2 4
Phase 4 1

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Depressive Symptoms Trial Landscape

61 indexed Depressive Symptoms studies · 28 recruiting (46%).

Phase mix: 1 late (III/IV) vs 5 early (I/II).

Top sponsor: Johns Hopkins University (3 trials), 9 others listed. 50 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Depressive Symptoms?

PlainTrial tracks 61 US clinical trials for Depressive Symptoms, of which 28 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Depressive Symptoms?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.