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Depressive Symptoms clinical trials
Every US clinical trial registered for Depressive Symptoms — phase mix, recruiting status, and the sponsors running them, straight from the NIH ClinicalTrials.gov registry.
61 US clinical trials · 28 currently recruiting
The research picture
Depressive Symptoms has 61 registered US clinical trials, 28 of them open to new participants right now — about 46% of the total.
- 28
- recruiting participants now
- 46%
- of trials open to enrollment
- 1
- in Phase 3–4 (later-stage)
- 3
- top sponsor: Johns Hopkins University
Counts reflect the public ClinicalTrials.gov registry as last mirrored by PlainTrial. Status and phase are reported by each study's sponsor. This is reference information, not medical advice.
Active & Recent Trials
My Wellbeing Guide: a Novel Tool for Managing Stress and Improving Quality of Life
Northwestern University
NCT05369429
A Remotely Delivered Tai Chi/Qigong Intervention for Older People Living With HIV
Florida International University
NCT06586619
Cancer Pain Management Using a Web-based Intervention
University of Texas at Austin
NCT06085313
Our Voices Matter: Intervention for Depression in Youth
Ann & Robert H Lurie Children's Hospital of Chicago
NCT07216326
IMPACT (IMproving Proactive Approaches for Cancer Survivors' Mental Health Treatment)
Medical University of South Carolina
NCT06582784
rTMS for Military TBI-related Depression
Henry M. Jackson Foundation for the Advancement of Military Medicine
NCT05426967
Family Spirit Strengths
Johns Hopkins Bloomberg School of Public Health
NCT05836090
Benefits of Outdoor Walks in Reducing Depressive Symptoms
University of Washington
NCT06989801
A New Clinical Model for the Engagement of Latinx Youth With Suicidal Behavior
Bradley Hospital
NCT06882798
RXWell to Decrease Post-Operative Opioid Use in Total Knee or Hip Arthroplasty
University of Pittsburgh
NCT05658796
Reward Processing and Depressive Subtypes: Identifying Neural Biotypes
San Francisco Veterans Affairs Medical Center
NCT06080646
Strengthening Health and Insight in New Educators
University of Alabama, Tuscaloo
NCT06745934
Caregiver Stress and Sleep Study
University of Pittsburgh
NCT05219955
Survivorship Care for Women Living With Ovarian Cancer: (POSTCARE-O)
Baylor College of Medicine
NCT05752448
Video-feedback Intervention to Promote Racial-Ethnic Socialization Competency (VIP-RACE)
Penn State University
NCT07055906
Building Resilience for Surgical Recovery
The University of Texas Health Science Center, Houston
NCT06174701
Expressive Writing on Minority Stressors Among Sexual Minority Veterans
VA Office of Research and Development
NCT05897021
Michigan Men's Diabetes Project III(MenDIII): Mind and Motion
University of Michigan
NCT06574035
Cannabidiol for Reduction of Brain Neuroinflammation
Massachusetts General Hospital
NCT05066308
Mood and Thought Process Study
Butler Hospital
NCT05585775
Acute and Long-Term Antidepressant Treatment Success in Adolescents With Anxiety (AtLAS-A)
University of Cincinnati
NCT04245436
Mind-Body Skills Group for Graduate Students
Weill Medical College of Cornell University
NCT05447689
BTL-699-2 and HPM-6000UF Devices for the Improvement of Depressive Symptoms and Sexual Function Among Perimenopausal and Postmenopausal Women
BTL Industries
NCT07413705
BTL-699-2 and HPM-6000UF Devices for the Improvement of Depressive Symptoms and Urinary Incontinence in Postpartum and Early Post-Childbirth Women
BTL Industries
NCT07413692
Mobile CBT for Middle Aged and Older Adults
Weill Medical College of Cornell University
NCT05754151
Improving Mood for Adolescents Through Teaming With End-Users in Routine Care (The iMATTER Project)
Children's Hospital of Philadelphia
NCT07020572
VR-PMR for Post-Burn Symptoms
Johns Hopkins University
NCT07317271
Psilocybin for Depression in People With Mild Cognitive Impairment or Early Alzheimer's Disease
Johns Hopkins University
NCT04123314
Northern Manhattan Study of Metabolism and Mind
Columbia University
NCT02470260
Evaluating a Virtual Mentoring Program Plus Mental Health Videos for Teens
Appa Health
NCT06138730
A Trial of a Positive Psychology Intervention for Older Adults (RESET)
University of Michigan
NCT05451589
Treatment for Migraine and Mood
Amanda Shallcross
NCT05576467
Digital Therapeutic for Depression After Head Injury in Current and Former US Military Personnel
Henry M. Jackson Foundation for the Advancement of Military Medicine
NCT05147506
Neurotechnology Following Traumatic Brain Injury
Brain State Technologies
NCT03649958
Virtual Reality in Hemodialysis to Improve Psychological Well-being
University of Illinois at Urbana-Champaign
NCT05642364
Pain Reduction Through Empowered Recovery (PRIME) Study
Johns Hopkins University
NCT05619510
Glutamatergic Modulation as a Treatment for Depressive Symptoms Among Patients With Post-acute Sequelae of COVID (PASC): A Pilot Trial
New York State Psychiatric Institute
NCT05690503
Rare Group Problem Management Plus
Children's National Research Institute
NCT06548022
Brief Video Interventions for Depression
Ohio State University
NCT04643964
Evaluation of an Entrepreneurship Program for American-Indian Youth
Johns Hopkins Bloomberg School of Public Health
NCT02157493
An IT Approach to Implementing Depression Treatment in Cardiac Patients (iHeart DepCare)
Columbia University
NCT03882411
Guided Feedback in an Online Game Impacts Decision Making
Bard College
NCT05925816
Insomnia Self-Management in Heart Failure
Yale University
NCT02660385
Building Resiliency and Increasing Community Hope
University of California, Los Angeles
NCT01698047
Study to Evaluate TNX-601 ER Monotherapy Versus Placebo in Patients With Major Depressive Disorder (MDD)
Tonix Pharmaceuticals
NCT05686408
Preventing Depression in People With Epilepsy: an Extension of Project UPLIFT
Emory University
NCT01941706
College Student Stress: Transitions Over Time
University of Michigan
NCT06583096
A Self-directed Mobile Mindfulness Intervention to Address Distress and Burnout in Frontline Healthcare Workers
Duke University
NCT04816708
Effects of a Single-session Implicit Theories of Personality Intervention on Early Adolescent Psychopathology
Harvard University
NCT03132298
Adapting Project UPLIFT for Blacks in Georgia
Morehouse School of Medicine
NCT02909387
Testing a Positive Psychology-based Intervention for Couples Coping With Stroke
University of Utah
NCT03335358
Stepped-Care Telehealth for Distress in Cancer Survivors
Wake Forest University Health Sciences
NCT03060096
Accelerated Resolution Therapy for Complicated Grief
University of South Florida
NCT03484338
Examine the Effects of Meditation on Daily Psychological Stress Responses in Woman With a History of Child Adversity
University of California, San Francis
NCT04606199
Stress-reduction Wellness Program for Midlife Black Women (B-SWELL)
University of Cincinnati
NCT04404478
Vitamin D for Improving Metabolic Control and Depressive Symptoms
Loyola University
NCT01185574
Attachment and Biobehavioral Catch-up for Depression
University of California, San Francis
NCT04050202
Beating the Blues for Your Heart
Indiana University
NCT01605552
Internet-Based Cognitive Behavioral Therapy for Depressive Symptoms in Adolescents With Type 1 Diabetes Mellitus
University of Texas Southwestern Medical Center
NCT03655067
Can Rumination-Focused Cognitive Behavioral Therapy Reduce the Risk of Cardio-vascular Disease?
University of Louisville
NCT05980130
Programs to Support You During Chemotherapy (Pro-You)
Vanderbilt-Ingram Cancer Center
NCT02148406
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 1 |
| Phase 2 | 4 |
| Phase 4 | 1 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Depressive Symptoms Trial Landscape
ClinicalTrials.gov lists 61 US studies indexed under Depressive Symptoms, and 28 of those are currently open to recruitment — roughly 46% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
The phase distribution for Depressive Symptoms shows 1 late-stage studies (Phase 3 and Phase 4 combined) alongside 5 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
Top sponsor activity for Depressive Symptoms is led by Johns Hopkins University with 3 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 61 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Depressive Symptoms?
PlainTrial tracks 61 US clinical trials for Depressive Symptoms, of which 28 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Depressive Symptoms?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology — how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.