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Depressive Symptoms: early-phase trial registry
28 of 61 indexed Depressive Symptoms trials are currently recruiting, with more weight in Phase 1-2.
Corpus placement: #232 of 28,707 conditions by registered trial count.
61 US clinical trials · 28 currently recruiting · #232 of 28,707 conditions by registered trial count
Depressive Symptoms: 61 US clinical trials tracked, 28 recruiting.
Depressive Symptoms is the subject of 61 registered US clinical trials on ClinicalTrials.gov, 28 of them currently open to new participants. 1 are in Phase 3-4 (later-stage) and 5 in Phase 1-2 (earlier-stage). The most active sponsor is Johns Hopkins University, running 3 of these trials.
Enrollment posture brief
Registry condition depressive-symptoms
OPEN 28 | RECR 46% | LATE 1 | EARLY 5 | RANK #232 | SPON 3
Volume-matched condition peers
Nearest open-share peer: Breastfeeding (46% recruiting · 37 trials)
Depressive Symptoms lists 28 open slots (46% of 61 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Depressive Symptoms on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Depressive Symptoms is recruiting above its size-band peers.
28 of 61 indexed trials (45.9%) are open to enrollment, against a 39.7% average across 762 conditions with 20-99 trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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Sponsorship of Depressive Symptoms trials is spread across many organizations.
Johns Hopkins University accounts for 3 of 61 trials (4.9%). 49 distinct sponsors appear on at least one study for this condition label.
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Typical Depressive Symptoms enrolment sits around 96 participants.
Median target enrolment is 96 among the 61 trials that report a genuine target (sentinel values excluded). 31 of those (50.8%) plan for fewer than 100 participants.
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Depressive Symptoms research is mostly interventional.
59 interventional and 2 observational studies make up this index (96.7% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
61 total, page 1 of 2
My Wellbeing Guide: a Novel Tool for Managing Stress and Improving Quality of Life
Northwestern University
NCT05369429
A Remotely Delivered Tai Chi/Qigong Intervention for Older People Living With HIV
Florida International University
NCT06586619
Cancer Pain Management Using a Web-based Intervention
University of Texas at Austin
NCT06085313
Our Voices Matter: Intervention for Depression in Youth
Ann & Robert H Lurie Children's Hospital of Chicago
NCT07216326
IMPACT (IMproving Proactive Approaches for Cancer Survivors' Mental Health Treatment)
Medical University of South Carolina
NCT06582784
rTMS for Military TBI-related Depression
Henry M. Jackson Foundation for the Advancement of Military Medicine
NCT05426967
Family Spirit Strengths
Johns Hopkins Bloomberg School of Public Health
NCT05836090
Benefits of Outdoor Walks in Reducing Depressive Symptoms
University of Washington
NCT06989801
A New Clinical Model for the Engagement of Latinx Youth With Suicidal Behavior
Bradley Hospital
NCT06882798
RXWell to Decrease Post-Operative Opioid Use in Total Knee or Hip Arthroplasty
University of Pittsburgh
NCT05658796
Reward Processing and Depressive Subtypes: Identifying Neural Biotypes
San Francisco Veterans Affairs Medical Center
NCT06080646
Strengthening Health and Insight in New Educators
University of Alabama, Tuscaloo
NCT06745934
Caregiver Stress and Sleep Study
University of Pittsburgh
NCT05219955
Survivorship Care for Women Living With Ovarian Cancer: (POSTCARE-O)
Baylor College of Medicine
NCT05752448
Video-feedback Intervention to Promote Racial-Ethnic Socialization Competency (VIP-RACE)
Penn State University
NCT07055906
Building Resilience for Surgical Recovery
The University of Texas Health Science Center, Houston
NCT06174701
Expressive Writing on Minority Stressors Among Sexual Minority Veterans
VA Office of Research and Development
NCT05897021
Michigan Men's Diabetes Project III(MenDIII): Mind and Motion
University of Michigan
NCT06574035
Cannabidiol for Reduction of Brain Neuroinflammation
Massachusetts General Hospital
NCT05066308
Mood and Thought Process Study
Butler Hospital
NCT05585775
Acute and Long-Term Antidepressant Treatment Success in Adolescents With Anxiety (AtLAS-A)
University of Cincinnati
NCT04245436
Mind-Body Skills Group for Graduate Students
Weill Medical College of Cornell University
NCT05447689
BTL-699-2 and HPM-6000UF Devices for the Improvement of Depressive Symptoms and Sexual Function Among Perimenopausal and Postmenopausal Women
BTL Industries
NCT07413705
BTL-699-2 and HPM-6000UF Devices for the Improvement of Depressive Symptoms and Urinary Incontinence in Postpartum and Early Post-Childbirth Women
BTL Industries
NCT07413692
Mobile CBT for Middle Aged and Older Adults
Weill Medical College of Cornell University
NCT05754151
Improving Mood for Adolescents Through Teaming With End-Users in Routine Care (The iMATTER Project)
Children's Hospital of Philadelphia
NCT07020572
VR-PMR for Post-Burn Symptoms
Johns Hopkins University
NCT07317271
Psilocybin for Depression in People With Mild Cognitive Impairment or Early Alzheimer's Disease
Johns Hopkins University
NCT04123314
Northern Manhattan Study of Metabolism and Mind
Columbia University
NCT02470260
Evaluating a Virtual Mentoring Program Plus Mental Health Videos for Teens
Appa Health
NCT06138730
A Trial of a Positive Psychology Intervention for Older Adults (RESET)
University of Michigan
NCT05451589
Treatment for Migraine and Mood
Amanda Shallcross
NCT05576467
Digital Therapeutic for Depression After Head Injury in Current and Former US Military Personnel
Henry M. Jackson Foundation for the Advancement of Military Medicine
NCT05147506
Neurotechnology Following Traumatic Brain Injury
Brain State Technologies
NCT03649958
Virtual Reality in Hemodialysis to Improve Psychological Well-being
University of Illinois at Urbana-Champaign
NCT05642364
Pain Reduction Through Empowered Recovery (PRIME) Study
Johns Hopkins University
NCT05619510
Glutamatergic Modulation as a Treatment for Depressive Symptoms Among Patients With Post-acute Sequelae of COVID (PASC): A Pilot Trial
New York State Psychiatric Institute
NCT05690503
Rare Group Problem Management Plus
Children's National Research Institute
NCT06548022
Brief Video Interventions for Depression
Ohio State University
NCT04643964
Evaluation of an Entrepreneurship Program for American-Indian Youth
Johns Hopkins Bloomberg School of Public Health
NCT02157493
An IT Approach to Implementing Depression Treatment in Cardiac Patients (iHeart DepCare)
Columbia University
NCT03882411
Guided Feedback in an Online Game Impacts Decision Making
Bard College
NCT05925816
Insomnia Self-Management in Heart Failure
Yale University
NCT02660385
Building Resiliency and Increasing Community Hope
University of California, Los Angeles
NCT01698047
Study to Evaluate TNX-601 ER Monotherapy Versus Placebo in Patients With Major Depressive Disorder (MDD)
Tonix Pharmaceuticals
NCT05686408
Preventing Depression in People With Epilepsy: an Extension of Project UPLIFT
Emory University
NCT01941706
College Student Stress: Transitions Over Time
University of Michigan
NCT06583096
A Self-directed Mobile Mindfulness Intervention to Address Distress and Burnout in Frontline Healthcare Workers
Duke University
NCT04816708
Effects of a Single-session Implicit Theories of Personality Intervention on Early Adolescent Psychopathology
Harvard University
NCT03132298
Adapting Project UPLIFT for Blacks in Georgia
Morehouse School of Medicine
NCT02909387
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 1 |
| Phase 2 | 4 |
| Phase 4 | 1 |
Top Sponsors
Named interventions
Most-linked intervention names on Depressive Symptoms records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Depressive Symptoms trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Depressive Symptoms page
61 registered trials, 28 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 28 Depressive Symptoms trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- Johns Hopkins University sponsors the most Depressive Symptoms trials on record, review their full trial history before evaluating a specific study. See Johns Hopkins University's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Depressive Symptoms condition card totals 61 registered trials; most-linked intervention EMSELLA (HPM-6000UF) Sham Treatment; top US site state California. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.