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RECRUITING NA

The Dragon PLC Trial (DRAGON-PLC)

NCT06914648 · View on ClinicalTrials.gov ↗

Study Summary

The goal of the DRAGON PLC clinical trial is to determine whether portal vein embolization (PVE) combined with hepatic vein embolization (HVE) improves resectability and overall survival in patients with initially unresectable primary liver cancer compared to standard PVE alone. This trial specifically focuses on patients with hepatocellular carcinoma and cholangiocarcinoma. The main questions this trial aims to answer are whether combined PVE and HVE increases the proportion of patients who become resectable within 3 weeks and improves 5-year overall survival compared to PVE alone by enhancing liver hypertrophy. Participants will: * Undergo either standard PVE or combined PVE and HVE. * Have regular imaging to assess liver resectability. * Be monitored for survival outcomes up to 5 years after intervention.

Interventions

  • PROCEDURE Portal Vein Embolization
  • PROCEDURE Hepatic Vein Embolization

Study Locations (20)

Other

  • Monash Medical Center — Melbourne
  • Cliniques Universitaires Saint Luc, UCLouvain — Brussels
  • Jessa Hospital — Hasselt
  • UZ Brussel — Jette
  • AZ Groeninge Hospital Kortrijk — Kortrijk

Vienna

  • Medical University of Vienna — Vienna
  • Social Center South — Vienna

Connecticut

  • Yale School of Medicine Hospital — New Haven

Illinois

  • Rush University Medical Center — Chicago

Minnesota

  • Mayo Clinic — Rochester

New York

  • Memorial Sloan Kettering Cancer Center — New York

Ohio

  • Cleveland Clinic — Cleveland

Brussels Capital

  • Erasmus Hospital — Brussels

Trial Details

FieldValue
Enrollment Target 358 participants
Start Date 2025-04-01
Est. Completion 2032-11-15
Phase NA

Sponsor

Maastricht University

2 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT06914648

The ClinicalTrials.gov registry entry for NCT06914648 describes a study currently listed as recruiting. It is categorized as NA, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 358 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Maastricht University, which has 2 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 3 conditions, with Cholangiocarcinoma appearing as the primary indexed condition, and to 2 interventions — of which Portal Vein Embolization is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT06914648 reports 20 study locations spanning 15 distinct geographic areas — top geographies include Other, Vienna, Connecticut. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT06914648 about?

NCT06914648 is a clinical study titled "The Dragon PLC Trial (DRAGON-PLC)". The goal of the DRAGON PLC clinical trial is to determine whether portal vein embolization (PVE) combined with hepatic vein embolization (HVE) improves resectability and overall survival in patients with initially unresectable primary liver cancer compared to standard PVE alone. This trial specifica...

What is the current status of trial NCT06914648?

This trial is currently recruiting. It is a NA study. The enrollment target is 358 participants. The study started on 2025-04-01. Estimated completion is 2032-11-15.

What conditions does trial NCT06914648 study?

This clinical trial studies the following conditions: Cholangiocarcinoma, Hepatocellular Carcinoma (HCC), Primary Liver Cancer. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT06914648?

The interventions under investigation include: Portal Vein Embolization (PROCEDURE), Hepatic Vein Embolization (PROCEDURE). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT06914648?

This trial is sponsored by Maastricht University, which has 2 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT06914648 being conducted?

This trial has 20 study locations across Connecticut, Illinois, Minnesota, New York, Ohio. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial