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Atrial Fibrillation clinical trials
60 of 204 indexed Atrial Fibrillation trials are currently recruiting.
204 US clinical trials · 60 currently recruiting
Atrial Fibrillation is the subject of 204 registered US clinical trials on ClinicalTrials.gov, 60 of them currently open to new participants. 45 are in Phase 3-4 (later-stage) and 19 in Phase 1-2 (earlier-stage). The most active sponsor is The Cleveland Clinic, running 9 of these trials.
The research picture
Atrial Fibrillation has 204 registered US clinical trials, 60 of them open to new participants right now, about 29% of the total.
- 60
- recruiting participants now
- 29%
- of trials open to enrollment
- 45
- in Phase 3–4 (later-stage)
- 9
- top sponsor: The Cleveland Clinic
Active & Recent Trials
204 total, page 2 of 5
Prevention of Postoperative Atrial Fibrillation (POAF) Using Intra-Pericardial Amiodarone
University of Chicago
NCT06063538
Atrial Fibrosis in Obstructive Sleep Apnea Patients: A Pilot Study
Tulane University
NCT04814420
Use of 4D-ICE in Conjunction With TEE for Left Atrial Appendage Closure
Kansas City Heart Rhythm Research Foundation
NCT06061757
Renal Denervation + PVI vs PVI Alone for Persistent AF
University of Rochester
NCT05116384
Implanted Loop Recorders for Detection and Management of Arrhythmia With Bruton Tyrosine Kinase Inhibitors
Northwell Health
NCT05643235
Baseline Atrial Fibrosis Predicts Risk for Post-operative Atrial Fibrillation in Patients Undergoing Cardiac Surgery
Tulane University
NCT05014802
Safety and Efficacy of the Sentinel Cerebral Protection Device in Atrial Fibrillation Ablation
Malini Madhavan
NCT04685317
Chloroquine for Patients With Symptomatic Persistent Atrial Fibrillation: A Prospective Pilot Study
University of South Florida
NCT02932007
Dapagliflozin in Patients With Atrial Fibrillation (DAPA-AF)
University of Oklahoma
NCT05174052
The CoAGulation Biomarkers and Atrial Fibrillation (COAG-AF) Pilot Study
Tulane University
NCT04947657
A Study of Milvexian Versus Apixaban in Participants With Atrial Fibrillation
Janssen Research & Development
NCT05757869
Genomic Investigation of Cardiovascular Diseases
Scripps Translational Science Institute
NCT00722748
CHAMPION-AF Clinical Trial
Boston Scientific Corporation
NCT04394546
Amplatzer Amulet LAAO vs. NOAC
Abbott Medical Devices
NCT04226547
Realtime Diagnosis From Electrocardiogram Artificial Intelligence-Guided Screening for Atrial Fibrillation With Long Follow-Up (REGAL)
Mayo Clinic
NCT05923359
SIMPLAAFY Clinical Trial
Boston Scientific Corporation
NCT06521463
Confirm Rx Insertable Cardiac Monitor SMART Registry
Abbott Medical Devices
NCT03505801
PaTH Clinical Data Research Network (CDRN) Atrial Fibrillation (AF) Clinician-Patient Partnership Cohort
University of Pittsburgh
NCT02485288
Identification of Genetic, Biochemical and Hormonal Factors Contributing to Atrial Fibrillation
The Cleveland Clinic
NCT00599118
Electrocardiogram-based Artificial Intelligence-assisted Detection of Heart Disease
Tempus AI
NCT05442203
EdoxabaN foR IntraCranial Hemorrhage Survivors With Atrial Fibrillation (ENRICH-AF)
Population Health Research Institute
NCT03950076
STrategies for Catheter Ablation of peRsistent Atrial Fibrlllation
McGill University Health Centre/Research Institute of the McGill University Health Centre
NCT04428944
Amulet™ ADVANCE LAA
Abbott Medical Devices
NCT05997446
Acute Cognitive Changes During Atrial Fibrillation Episodes (AFCOG)
David Brunk, PA-C, MMS
NCT04033510
Insertable Cardiac Monitor for Primary Atrial Fibrillation Detection in High-Risk Heart Failure Patients
University of Rochester
NCT04818645
RESOLVE-AF: Clinical Evaluation of the Ablacath™ Mapping Catheter and Ablamap® System Utilizing Electrographic Flow (EGF) Mapping to Resolve Extra-PV Sources of Atrial Fibrillation and Guide Ablation Therapy.
Cortex
NCT05883631
Safety and Effectiveness of Pulmonary Vein isOLation And posterioR Wall Ablation wIth pulSed Field Energy in Patients With Paroxysmal and Persistent AF
Massachusetts General Hospital
NCT06099730
REView of ProcEdural FactoRs and Outcomes After Atrial Fibrillation Ablation With Active Esophageal COOLing: A Sub-Study of the REAL AF Registry
Heart Rhythm Clinical and Research Solutions
NCT06354777
Implementing Prescriber-Pharmacist Collaborative Care for Evidence-based Anticoagulant Use
University of Michigan
NCT05351749
AF at Home: A Virtual Education Program for Patients With Atrial Fibrillation (AF)
University of North Carolina, Chapel Hill
NCT05810896
Targeting Risk Interventions and Metformin for Atrial Fibrillation (TRIM-AF)
Mina Chung, MD
NCT03603912
A Study of IV HBI-3000 for the Conversion Recent Onset Atrial Fibrillation (AF)
HUYABIO International
NCT04680026
Therapeutic Initial Heparin Dosing for Patients With Clots or Certain Heart Conditions Admitted to the Hospital
Inova Health Care Services
NCT07250763
ECG Validation Study
Analog Device
NCT05445726
Atrial Fibrillation (AF) and Electrocardiogram (EKG) Interpretation Project ECHO
University of North Carolina, Chapel Hill
NCT05890274
Insertable Cardiac Monitor-Guided Early Intervention to Reduce Atrial Fibrillation Burden Following Catheter Ablation
University of Rochester
NCT04922281
Ablation Versus Medical Management of Atrial Fibrillation in HFpEF
Inova Health Care Services
NCT04282850
Liraglutide Effect in Atrial Fibrillation
University of Miami
NCT03856632
Non-Invasive Median Nerve Stimulation to Attenuate Atrial Tachyarrhythmias After Catheter Ablation for Atrial Fibrillation
Icahn School of Medicine at Mount Sinai
NCT06748157
Replication of the ARISTOTLE Anticoagulant Trial in Healthcare Claims Data
Brigham and Women's Hospital
NCT04593030
Effectiveness of Oral Anticoagulants in Elderly Patients With Non-Valvular Atrial Fibrillation and Heart Failure
Bristol-Myers Squibb
NCT03508271
Real-world Comparative Effectiveness of Rivaroxaban Versus VKA
Bayer
NCT02690155
GLORIA-AF Registry Program - Second and Third Phases
Boehringer Ingelheim
NCT01468701
Apixaban for the Prevention of Stroke in Subjects With Atrial Fibrillation
Bristol-Myers Squibb
NCT00412984
Randomized Evaluation of Long Term Anticoagulant Therapy (RE-LY) With Dabigatran Etexilate
Boehringer Ingelheim
NCT00262600
Clinical Outcomes Among Non-valvular Atrial Fibrillation Patients With Renal Dysfunction
Bayer
NCT03359876
Real-world Dosing Patterns of Rivaroxaban in the United States
Bayer
NCT03242278
Personalized Patient Data and Behavioral Nudges to Improve Adherence to Chronic Cardiovascular Medications
University of Colorado, Denver
NCT03973931
Atrial Fibrillation Clopidogrel Trial With Irbesartan for Prevention of Vascular Events (ACTIVE I)
Sanofi
NCT00249795
Atrial Fibrillation Clopidogrel Trial With Irbesartan for Prevention of Vascular Events (ACTIVE A)
Sanofi
NCT00249873
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 7 |
| Phase 2 | 12 |
| Phase 3 | 26 |
| Phase 4 | 19 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Atrial Fibrillation Trial Landscape
204 indexed Atrial Fibrillation studies · 60 recruiting (29%).
Phase mix: 45 late (III/IV) vs 19 early (I/II).
Top sponsor: The Cleveland Clinic (9 trials), 9 others listed. 50 shown below, recruiting first.
How to read this condition's trial landscape
That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Atrial Fibrillation?
PlainTrial tracks 204 US clinical trials for Atrial Fibrillation, of which 60 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Atrial Fibrillation?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology - how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.