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ClinicalTrials.gov 60 recruiting now official registry

Atrial Fibrillation clinical trials

60 of 204 indexed Atrial Fibrillation trials are currently recruiting.

204 US clinical trials · 60 currently recruiting

Atrial Fibrillation is the subject of 204 registered US clinical trials on ClinicalTrials.gov, 60 of them currently open to new participants. 45 are in Phase 3-4 (later-stage) and 19 in Phase 1-2 (earlier-stage). The most active sponsor is The Cleveland Clinic, running 9 of these trials.

The research picture

Atrial Fibrillation has 204 registered US clinical trials, 60 of them open to new participants right now, about 29% of the total.

60
recruiting participants now
29%
of trials open to enrollment
45
in Phase 3–4 (later-stage)
9
top sponsor: The Cleveland Clinic
Phase 17Phase 212Phase 326Phase 419

Active & Recent Trials

204 total, page 1 of 5

RECRUITING 17,198 participants

Get With the Guidelines Atrial Fibrillation Registry

American Heart Association

NCT06245187

RECRUITING 10,000 participants

Tracking Results of Ablations to Combat AF Registry Generation 2

AtriCure

NCT05111015

RECRUITING Phase 3 5,350 participants

The Rhythm Evaluation for AntiCoagulaTion With Continuous Monitoring of Atrial Fibrillation

Johns Hopkins University

NCT05836987

RECRUITING NA 4,000 participants

The Fourth Left Atrial Appendage Occlusion Study

Hamilton Health Sciences Corporation

NCT05963698

RECRUITING 4,000 participants

Identification of Genomic Predictors of Adverse Events After Cardiac Surgery

Brigham and Women's Hospital

NCT01258231

RECRUITING Phase 3 3,200 participants

Anticoagulation for New-Onset Post-Operative Atrial Fibrillation After CABG

Icahn School of Medicine at Mount Sinai

NCT04045665

RECRUITING 3,000 participants

The Vanderbilt Atrial Fibrillation Ablation Registry

Vanderbilt University

NCT02404415

RECRUITING 3,000 participants

Left Atrial Appendage Occlusion Registry (LAAO Registry)

American College of Cardiology

NCT02699957

RECRUITING Phase 4 2,270 participants

Anticoagulation for Stroke Prevention In Patients With Recent Episodes of Atrial Fibrillation Occurring Transiently With Stress

Population Health Research Institute

NCT03968393

RECRUITING NA 1,600 participants

The CONFORM Pivotal Trial

Conformal Medical

NCT05147792

RECRUITING NA 1,400 participants

Pericardiotomy in Cardiac Surgery

Population Health Research Institute

NCT06486636

RECRUITING 1,125 participants

Volunteers to Investigate Best Results for Ablation and Novel Therapies for Atrial Fibrillation

University of California, San Francisco

NCT05504356

RECRUITING 1,000 participants

MANAGE-AF Registry -MANAGEment of Atrial Fibrillation Outcomes Registry (MANAGE-AF)

CorVita Science Foundation

NCT05978466

RECRUITING 1,000 participants

COMparison of Physiological Algorithms for Real-time Evaluation of Atrial Fibrillation

Stanford University

NCT02997254

RECRUITING 1,000 participants

Development of CIRC Technologies

The Cleveland Clinic

NCT05654272

RECRUITING Phase 3 700 participants

Anticoagulation in ICH Survivors for Stroke Prevention and Recovery

Yale University

NCT03907046

RECRUITING 678 participants

Safety and Efficacy of Workflows of High Volume Single Operators in a LAAO Device Implant Procedural Day

Heart Rhythm Clinical and Research Solutions

NCT06436924

RECRUITING 580 participants

PULSED AF Post-Approval Study

Medtronic Cardiac Ablation Solutions

NCT06578104

RECRUITING NA 440 participants

A Study of Assessment on Safety and Effectiveness of BWI Pulsed Field Ablation With OMNYPULSE Catheter for the Treatment of Paroxysmal Atrial Fibrillation (PAF)

Biosense Webster

NCT06455098

RECRUITING 400 participants

Clinical and Healthcare Outcomes From Real-World Use in the United States of a Companion AI During AF Ablation

Volta Medical

NCT06056271

RECRUITING Phase 4 360 participants

Treatment Of Atrial Fibrillation In Preserved Cardiac Function Heart Failure

Electrophysiology Research Foundation

NCT04160000

RECRUITING 360 participants

Tulane iPredict, Prevent Study to Evaluate the Progression of Atrial Myopathy.

Tulane University School of Medicine

NCT04703166

RECRUITING NA 276 participants

A Study Assessing Long-Term Safety and Effectiveness in Treatment Management of Atrial Fibrillation With VARIPULSE Catheter System

Biosense Webster

NCT07227532

RECRUITING NA 250 participants

CardioFocus HeartLight Post-Approval Study

CardioFocus

NCT03168659

RECRUITING NA 248 participants

Mobile Health Technology-Enabled AFib Management

Johns Hopkins University

NCT06500988

RECRUITING 225 participants

Prospective Phenotyping for Genetic Subtypes of Early-onset Atrial Fibrillation

Vanderbilt University Medical Center

NCT05190679

RECRUITING Phase 2 220 participants

A Study of Stellate Ganglion Block for Prevention of Atrial Fibrillation

Mayo Clinic

NCT05357690

RECRUITING 200 participants

The Dynamics of Human Atrial Fibrillation

Stanford University

NCT05366361

RECRUITING 200 participants

Defining the Risk of Ventricular Tachycardia in Genetic Forms of Early-onset Atrial Fibrillation

Vanderbilt University Medical Center

NCT06647459

RECRUITING NA 200 participants

The Z Stitch Early Bed Rest Assessment Study

Oregon Health and Science University

NCT06087497

RECRUITING Phase 3 200 participants

Semaglutide for Metabolic Intervention and Adipose Loss to Treat Atrial Fibrillation

University of Chicago

NCT06499857

RECRUITING 200 participants

Defining the Risk of Ventricular Tachycardia in Genetic Cardiomyopathies

Vanderbilt University Medical Center

NCT06575881

RECRUITING Phase 1 165 participants

Positron Emission Tomography (PET) Imaging of Thrombosis

Massachusetts General Hospital

NCT03830320

RECRUITING Phase 2 165 participants

A Study to Investigate the Efficacy, Safety, Tolerability and Pharmacokinetics of PKN605 in Participants With Atrial Fibrillation

Novartis Pharmaceuticals

NCT07217067

RECRUITING Phase 4 162 participants

Pharmacogenetic Study of Antiarrhythmic Drugs for Atrial Fibrillation

University of Illinois at Chicago

NCT02347111

RECRUITING Phase 3 153 participants

Comparing Magnesium 2g Versus 4g Versus Placebo in the Incidence of Treating AFF RVR

Wake Forest University Health Sciences

NCT06376916

RECRUITING 150 participants

Assessing the Burden of Perioperative Atrial Fibrillation in Patients Undergoing Cardiac Surgery

Brigham and Women's Hospital

NCT04880265

RECRUITING NA 150 participants

Warfarin Patient Self-management Implementation in the US Healthcare System

University of Utah

NCT04766216

RECRUITING NA 135 participants

CellFX® Nanosecond Pulsed Field Ablation (nsPFA)™ Cardiac Surgery Clamp System to Treat Atrial Fibrillation

Pulse Biosciences

NCT06959121

RECRUITING NA 120 participants

Exercise Activity Intervention With Sensor-Based Engagement in Patients With Atrial Fibrillation

Icahn School of Medicine at Mount Sinai

NCT06938412

RECRUITING 120 participants

Machine Learning in Atrial Fibrillation

Stanford University

NCT05371405

RECRUITING NA 110 participants

Vascular Closure With a Device Compared to Manual Compression After Atrial Fibrillation Ablation: The LockeT II Study

Kansas City Heart Rhythm Research Foundation

NCT06078735

RECRUITING Phase 2 100 participants

TIRzepatide for the Treatment of Obesity in Patients With Atrial Fibrillation

The Cleveland Clinic

NCT06802081

RECRUITING NA 100 participants

320-detector Computed Tomography to Assess Myocardial Extracellular Volume Fraction in Patients With Atrial Fibrillation Before AF Ablation.

Johns Hopkins University

NCT06308094

RECRUITING 100 participants

Long-Term Outcomes of LAA Contrast Flow in CT Scans After Endocardial LAA Closure: The CF-CT Registry

Kansas City Heart Rhythm Research Foundation

NCT06075628

RECRUITING NA 100 participants

Intracardiac Echocardiography Guided Watchman Device Implant

The Cleveland Clinic

NCT06007872

RECRUITING Phase 2 90 participants

Amiodarone for the Prevention of Atrial Fibrillation After Minimally Invasive Esophagectomy in Patients With Esophageal Cancer

OHSU Knight Cancer Institute

NCT06067438

RECRUITING Phase 1 90 participants

Synaptic Plasticity in the Epicardial Ganglionated Plexi

University of Oklahoma

NCT05034419

RECRUITING Phase 4 80 participants

Ondansetron for the Management of Atrial Fibrillation

Indiana University

NCT05844501

RECRUITING 75 participants

Surveillance Trial of the Apple Watch in Reliable Burden Assessment in Unseen Recurrence of Surgically Treated AF

The Cleveland Clinic

NCT07122947

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Phase Distribution

PhaseTrial count
Phase 1 7
Phase 2 12
Phase 3 26
Phase 4 19

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Atrial Fibrillation Trial Landscape

204 indexed Atrial Fibrillation studies · 60 recruiting (29%).

Phase mix: 45 late (III/IV) vs 19 early (I/II).

Top sponsor: The Cleveland Clinic (9 trials), 9 others listed. 50 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Atrial Fibrillation?

PlainTrial tracks 204 US clinical trials for Atrial Fibrillation, of which 60 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Atrial Fibrillation?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.