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A Study of Milvexian Versus Apixaban in Participants With Atrial Fibrillation
NCT05757869 · View on ClinicalTrials.gov ↗
Study Summary
The purpose of this study is to evaluate if milvexian is at least as effective as apixaban for reducing the risk of the composite stroke and non-central nervous system (CNS) systemic embolism.
Conditions Studied
Interventions
- DRUG Placebo
- DRUG Apixaban
- DRUG Milvexian
- DRUG Apixaban Placebo
Study Locations (20)
California
- Bakersfield Memorial Hospital — Bakersfield
- Vitality Clinical Research — Beverly Hills
- Chula Vista Cardiac Clinic — Chula Vista
- Sharp Chula Vista Medical Center — Chula Vista
- Mission Cardiovascular Research Institute — Fremont
- Paradise Clinical Research Group LLC — Glendora
- Miller Children's at Long Beach Medical Center — Long Beach
- Los Angeles Cardiology Associates — Los Angeles
- University of Southern California — Los Angeles
Alabama
- Advanced Cardiovascular, LLC — Alexander City
- Ascension St. Vincent's Health System — Birmingham
- SEC Clinical Research — Dothan
- HH Heart Center and Heart Center — Huntsville
- CB Flock Research Corporation — Mobile
Arizona
- Mercy Gilbert Medical Center — Gilbert
- Valleywise Health Medical Center — Phoenix
- Arizona Arrhythmia Research Center — Phoenix
- Arizona Heart Hospital — Phoenix
- HonorHealth Neurology — Scottsdale
Arkansas
- Arkansas Heart Hospital — Little Rock
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 20,284 participants |
| Start Date | 2023-04-11 |
| Est. Completion | 2026-10-31 |
| Phase | Phase 3 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT05757869
The ClinicalTrials.gov registry entry for NCT05757869 describes a study currently listed as active not recruiting. It is categorized as Phase 3, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 20,284 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Janssen Research & Development, which has 442 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 1 condition, with Atrial Fibrillation appearing as the primary indexed condition, and to 4 interventions — of which Placebo is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT05757869 reports 20 study locations spanning 4 distinct geographic areas — top geographies include California, Alabama, Arizona. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT05757869 about?
NCT05757869 is a clinical study titled "A Study of Milvexian Versus Apixaban in Participants With Atrial Fibrillation". The purpose of this study is to evaluate if milvexian is at least as effective as apixaban for reducing the risk of the composite stroke and non-central nervous system (CNS) systemic embolism.
What is the current status of trial NCT05757869?
This trial is currently active not recruiting. It is a Phase 3 study. The enrollment target is 20,284 participants. The study started on 2023-04-11. Estimated completion is 2026-10-31.
What conditions does trial NCT05757869 study?
This clinical trial studies the following conditions: Atrial Fibrillation. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT05757869?
The interventions under investigation include: Placebo (DRUG), Apixaban (DRUG), Milvexian (DRUG), Apixaban Placebo (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT05757869?
This trial is sponsored by Janssen Research & Development, which has 442 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT05757869 being conducted?
This trial has 20 study locations across Alabama, Arizona, Arkansas, California. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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