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ClinicalTrials.gov 60 recruiting now official registry

Atrial Fibrillation clinical trials

60 of 204 indexed Atrial Fibrillation trials are currently recruiting.

204 US clinical trials · 60 currently recruiting

Atrial Fibrillation is the subject of 204 registered US clinical trials on ClinicalTrials.gov, 60 of them currently open to new participants. 45 are in Phase 3-4 (later-stage) and 19 in Phase 1-2 (earlier-stage). The most active sponsor is The Cleveland Clinic, running 9 of these trials.

The research picture

Atrial Fibrillation has 204 registered US clinical trials, 60 of them open to new participants right now, about 29% of the total.

60
recruiting participants now
29%
of trials open to enrollment
45
in Phase 3–4 (later-stage)
9
top sponsor: The Cleveland Clinic
Phase 17Phase 212Phase 326Phase 419

Active & Recent Trials

204 total, page 3 of 5

COMPLETED Phase 3 4,628 participants

A Trial With Dronedarone to Prevent Hospitalization or Death in Patients With Atrial Fibrillation

Sanofi

NCT00174785

COMPLETED Phase 3 2,725 participants

Evaluation of Dual Therapy With Dabigatran vs. Triple Therapy With Warfarin in Patients With AF That Undergo a PCI With Stenting (REDUAL-PCI)

Boehringer Ingelheim

NCT02164864

COMPLETED Phase 3 1,516 participants

Omega-3 Fatty Acids for Prevention of Post-Operative Atrial Fibrillation

Brigham and Women's Hospital

NCT00970489

COMPLETED Phase 4 1,500 participants

Study Of The Blood Thinner, Apixaban, For Patients Who Have An Abnormal Heart Rhythm (Atrial Fibrillation) And Expected To Have Treatment To Put Them Back Into A Normal Heart Rhythm (Cardioversion)

Pfizer

NCT02100228

COMPLETED Phase 4 1,067 participants

A Prospective, Open Label Study Evaluating Two Management Strategies on Gastrointestinal Symptoms in Patients Newly on Treatment With Pradaxa for the Prevention of Stroke and Systemic Embolism With Non-valvular Atrial Fibrillation

Boehringer Ingelheim

NCT01493557

COMPLETED Phase 2 673 participants

Placebo Controlled Double-blind Dose Ranging Study of the Efficacy and Safety of SSR149744C 50, 100, 200 or 300 mg OD With Amiodarone as Calibrator for the Maintenance of Sinus Rhythm in Patients With Recent Atrial Fibrillation/Flutter

Sanofi

NCT00233441

COMPLETED 650 participants

Solutions for Atrial Fibrillation Edvocacy (SAFE)

American Pharmacists Association Foundation

NCT05067114

COMPLETED NA 650 participants

Withings ECG-Monitor Study

Withings

NCT05316337

COMPLETED Phase 3 629 participants

American-Australian-African Trial With Dronedarone in Patients With Atrial Fibrillation or Atrial Flutter for the Maintenance of Sinus Rhythm

Sanofi

NCT00259376

COMPLETED NA 608 participants

EHR-Embedded Decision Support to Prevent Stroke in Patients With AF

University of Cincinnati

NCT04099485

COMPLETED NA 602 participants

Electrocardiogram Clinical Validation Study

Apple

NCT03492554

COMPLETED 581 participants

Understanding and Improving Anticoagulation Dosing for Patients With Atrial Fibrillation

Duke University

NCT03719144

COMPLETED NA 561 participants

LEAVE Safe With DOACs

University of Massachusetts, Worcester

NCT04068727

COMPLETED NA 546 participants

Clinical Trial Comparing Devices Used for Cardioversion of Atrial Fibrillation

Inova Health Care Services

NCT05992623

COMPLETED 519 participants

Atrial Fibrillation/Flutter Outcome Risk Determination

Vanderbilt University

NCT01138644

COMPLETED Phase 3 504 participants

Efficacy & Safety of Dronedarone Versus Amiodarone for the Maintenance of Sinus Rhythm in Patients With Atrial Fibrillation

Sanofi

NCT00489736

COMPLETED 497 participants

AMBULATE VASCADE MVP Same Day Discharge Retrospective Registry

Cardiva Medical

NCT04538781

COMPLETED Phase 2 455 participants

Renin-angiotensin-aldosterone System (RAAS), Inflammation, and Post-Operative Atrial Fibrillation (AF)

Vanderbilt University

NCT00141778

COMPLETED 450 participants

Sensing Atrial High Rate Episodes With Implantable Cardioverter-Defibrillators Trial (The SENSE Trial)

Weill Medical College of Cornell University

NCT02186704

COMPLETED Phase 3 446 participants

Efficacy and Safety of Azimilide for the Treatment of Patients With Atrial Fibrillation

Forest Laboratories

NCT00035477

COMPLETED Phase 4 444 participants

Effect of Oral and Intravenous Diltiazem Protocol for Emergency Department Atrial Fibrillation

Corewell Health South

NCT05391893

COMPLETED Phase 3 431 participants

Efficacy and Safety of Azimilide in the Prophylactic Treatment of Patients With Atrial Fibrillation.

Forest Laboratories

NCT00035464

COMPLETED NA 421 participants

Pulsed Field Ablation to Irreversibly Electroporate Tissue and Treat AF

Medtronic Cardiac Ablation Solutions

NCT04198701

COMPLETED NA 400 participants

Outcome of Atrial Fibrillation Ablation After Permanent Pulmonary Vein Antrum Isolation With or Without Proven Left Atrial Posterior Wall Isolation

Texas Cardiac Arrhythmia Research Foundation

NCT01660100

COMPLETED NA 373 participants

WIBOFA - Validation of SCT02 With ECG-App for Detection of AF

Withings

NCT06351761

COMPLETED Phase 3 356 participants

Phase III Tolerance and Efficacy Study of RSD1235 in Patients With Atrial Fibrillation

Advanz Pharma

NCT00468767

COMPLETED NA 344 participants

Study to Develop a Reliable Nomogram That Incorporates Clinical and Genetic Information

Brigham and Women's Hospital

NCT00401414

COMPLETED 339 participants

DECAAF: Delayed-Enhancement MRI (DE-MRI) Determinant of Successful Radiofrequency Catheter Ablation of Atrial Fibrillation

University of Utah

NCT01150214

COMPLETED NA 317 participants

Influence of Sleep Apnea on Risk of Atrial Fibrillation

The Cleveland Clinic

NCT02576587

COMPLETED Phase 3 304 participants

Prophylaxis to Reduce Postoperative Atrial Fibrillation in Cardiac Surgery

MaineHealth

NCT00953212

COMPLETED Phase 3 276 participants

Study to Determine the Response and Effectiveness of RSD1235 in Subjects With Atrial Fibrillation or Atrial Flutter

Astellas Pharma

NCT00115791

COMPLETED 271 participants

Evaluation of the Accuracy and Precision of the INRatio® Prothrombin Time (PT) Monitoring System With New INRatio Test Strip Designed for Low Sample Volume and Heparin Insensitivity

Abbott RDx Cardiometabolic

NCT01037270

COMPLETED NA 264 participants

iPhone Helping Evaluate Atrial Fibrillation Rhythm Through Technology

Columbia University

NCT02731326

COMPLETED Phase 4 260 participants

Fish Oil for Reduction of Atrial Fibrillation After Cardiac Surgery

Chirag Sandesara

NCT00446966

COMPLETED NA 256 participants

Video-based Detection of Atrial Fibrillation

University of Rochester

NCT04267133

COMPLETED Phase 3 253 participants

A Study Exploring Two Treatment Strategies in Patients With Atrial Fibrillation Who Undergo Catheter Ablation Therapy

Janssen Scientific Affairs

NCT01729871

COMPLETED 251 participants

Eliminate Thromboembolism: Improving Anticoagulation in Non-valvular Atrial Fibrillation Patients

Duke University

NCT02461602

COMPLETED 245 participants

Atrial Fibrillation Screening in Nursing Homes

State University of New York at Buffalo

NCT03860246

COMPLETED NA 225 participants

STOP AF First: Cryoballoon Catheter Ablation in an Antiarrhythmic Drug Naive Paroxysmal Atrial Fibrillation

Medtronic Cardiac Ablation Solutions

NCT03118518

COMPLETED Phase 2 221 participants

Study of RSD1235-SR for the Prevention of Atrial Fibrillation/Atrial Flutter Recurrence

Advanz Pharma

NCT00267930

COMPLETED 220 participants

Management of Gastrointestinal and Urogenital (GI/GU) Bleedings in Atrial Fibrillation Patients Using Pradaxa

Boehringer Ingelheim

NCT02022020

COMPLETED 219 participants

QT Variability Pre and Post Cardioversion

Vanderbilt University

NCT00885391

COMPLETED 200 participants

A Genomic Approach to Warfarin Dose Prescription in Admixed Caribbean Hispanics

University of Puerto Ri

NCT02345356

COMPLETED Phase 4 190 participants

Evaluating the Effectiveness of Fish Oil Supplements at Reducing the Recurrence of Atrial Fibrillation

Vanderbilt University

NCT00552084

COMPLETED NA 186 participants

STOP Persistent AF

Medtronic Cardiac Ablation Solutions

NCT03012841

COMPLETED Phase 3 176 participants

Effect of Amiodarone on the Procedure Outcome in Long-standing Persistent Atrial Fibrillation Undergoing Pulmonary Vein Antral Isolation

Texas Cardiac Arrhythmia Research Foundation

NCT01173809

COMPLETED 175 participants

Early Detection and Treatment of Esophageal Injury After Catheter Ablation for Atrial Fibrillation

University of Oklahoma

NCT00584922

COMPLETED NA 174 participants

Safety and Efficacy of CryoCor™ Cryoablation for PAF

Boston Scientific Corporation

NCT00231296

COMPLETED Phase 3 173 participants

Effect of Catheter Ablation on Clinical Course of Migraine in AF Patients With or Without Previous History of Migraine

Texas Cardiac Arrhythmia Research Foundation

NCT01391091

COMPLETED 160 participants

Study Watch Atrial Fibrillation (AF) Detection Investigation

Verily Life Sciences

NCT04074434

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Phase Distribution

PhaseTrial count
Phase 1 7
Phase 2 12
Phase 3 26
Phase 4 19

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Atrial Fibrillation Trial Landscape

204 indexed Atrial Fibrillation studies · 60 recruiting (29%).

Phase mix: 45 late (III/IV) vs 19 early (I/II).

Top sponsor: The Cleveland Clinic (9 trials), 9 others listed. 50 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Atrial Fibrillation?

PlainTrial tracks 204 US clinical trials for Atrial Fibrillation, of which 60 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Atrial Fibrillation?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.