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Atrial Fibrillation clinical trials
60 of 204 indexed Atrial Fibrillation trials are currently recruiting.
204 US clinical trials · 60 currently recruiting
Atrial Fibrillation is the subject of 204 registered US clinical trials on ClinicalTrials.gov, 60 of them currently open to new participants. 45 are in Phase 3-4 (later-stage) and 19 in Phase 1-2 (earlier-stage). The most active sponsor is The Cleveland Clinic, running 9 of these trials.
The research picture
Atrial Fibrillation has 204 registered US clinical trials, 60 of them open to new participants right now, about 29% of the total.
- 60
- recruiting participants now
- 29%
- of trials open to enrollment
- 45
- in Phase 3–4 (later-stage)
- 9
- top sponsor: The Cleveland Clinic
Active & Recent Trials
204 total, page 3 of 5
A Trial With Dronedarone to Prevent Hospitalization or Death in Patients With Atrial Fibrillation
Sanofi
NCT00174785
Evaluation of Dual Therapy With Dabigatran vs. Triple Therapy With Warfarin in Patients With AF That Undergo a PCI With Stenting (REDUAL-PCI)
Boehringer Ingelheim
NCT02164864
Omega-3 Fatty Acids for Prevention of Post-Operative Atrial Fibrillation
Brigham and Women's Hospital
NCT00970489
Study Of The Blood Thinner, Apixaban, For Patients Who Have An Abnormal Heart Rhythm (Atrial Fibrillation) And Expected To Have Treatment To Put Them Back Into A Normal Heart Rhythm (Cardioversion)
Pfizer
NCT02100228
A Prospective, Open Label Study Evaluating Two Management Strategies on Gastrointestinal Symptoms in Patients Newly on Treatment With Pradaxa for the Prevention of Stroke and Systemic Embolism With Non-valvular Atrial Fibrillation
Boehringer Ingelheim
NCT01493557
Placebo Controlled Double-blind Dose Ranging Study of the Efficacy and Safety of SSR149744C 50, 100, 200 or 300 mg OD With Amiodarone as Calibrator for the Maintenance of Sinus Rhythm in Patients With Recent Atrial Fibrillation/Flutter
Sanofi
NCT00233441
Solutions for Atrial Fibrillation Edvocacy (SAFE)
American Pharmacists Association Foundation
NCT05067114
Withings ECG-Monitor Study
Withings
NCT05316337
American-Australian-African Trial With Dronedarone in Patients With Atrial Fibrillation or Atrial Flutter for the Maintenance of Sinus Rhythm
Sanofi
NCT00259376
EHR-Embedded Decision Support to Prevent Stroke in Patients With AF
University of Cincinnati
NCT04099485
Electrocardiogram Clinical Validation Study
Apple
NCT03492554
Understanding and Improving Anticoagulation Dosing for Patients With Atrial Fibrillation
Duke University
NCT03719144
LEAVE Safe With DOACs
University of Massachusetts, Worcester
NCT04068727
Clinical Trial Comparing Devices Used for Cardioversion of Atrial Fibrillation
Inova Health Care Services
NCT05992623
Atrial Fibrillation/Flutter Outcome Risk Determination
Vanderbilt University
NCT01138644
Efficacy & Safety of Dronedarone Versus Amiodarone for the Maintenance of Sinus Rhythm in Patients With Atrial Fibrillation
Sanofi
NCT00489736
AMBULATE VASCADE MVP Same Day Discharge Retrospective Registry
Cardiva Medical
NCT04538781
Renin-angiotensin-aldosterone System (RAAS), Inflammation, and Post-Operative Atrial Fibrillation (AF)
Vanderbilt University
NCT00141778
Sensing Atrial High Rate Episodes With Implantable Cardioverter-Defibrillators Trial (The SENSE Trial)
Weill Medical College of Cornell University
NCT02186704
Efficacy and Safety of Azimilide for the Treatment of Patients With Atrial Fibrillation
Forest Laboratories
NCT00035477
Effect of Oral and Intravenous Diltiazem Protocol for Emergency Department Atrial Fibrillation
Corewell Health South
NCT05391893
Efficacy and Safety of Azimilide in the Prophylactic Treatment of Patients With Atrial Fibrillation.
Forest Laboratories
NCT00035464
Pulsed Field Ablation to Irreversibly Electroporate Tissue and Treat AF
Medtronic Cardiac Ablation Solutions
NCT04198701
Outcome of Atrial Fibrillation Ablation After Permanent Pulmonary Vein Antrum Isolation With or Without Proven Left Atrial Posterior Wall Isolation
Texas Cardiac Arrhythmia Research Foundation
NCT01660100
WIBOFA - Validation of SCT02 With ECG-App for Detection of AF
Withings
NCT06351761
Phase III Tolerance and Efficacy Study of RSD1235 in Patients With Atrial Fibrillation
Advanz Pharma
NCT00468767
Study to Develop a Reliable Nomogram That Incorporates Clinical and Genetic Information
Brigham and Women's Hospital
NCT00401414
DECAAF: Delayed-Enhancement MRI (DE-MRI) Determinant of Successful Radiofrequency Catheter Ablation of Atrial Fibrillation
University of Utah
NCT01150214
Influence of Sleep Apnea on Risk of Atrial Fibrillation
The Cleveland Clinic
NCT02576587
Prophylaxis to Reduce Postoperative Atrial Fibrillation in Cardiac Surgery
MaineHealth
NCT00953212
Study to Determine the Response and Effectiveness of RSD1235 in Subjects With Atrial Fibrillation or Atrial Flutter
Astellas Pharma
NCT00115791
Evaluation of the Accuracy and Precision of the INRatio® Prothrombin Time (PT) Monitoring System With New INRatio Test Strip Designed for Low Sample Volume and Heparin Insensitivity
Abbott RDx Cardiometabolic
NCT01037270
iPhone Helping Evaluate Atrial Fibrillation Rhythm Through Technology
Columbia University
NCT02731326
Fish Oil for Reduction of Atrial Fibrillation After Cardiac Surgery
Chirag Sandesara
NCT00446966
Video-based Detection of Atrial Fibrillation
University of Rochester
NCT04267133
A Study Exploring Two Treatment Strategies in Patients With Atrial Fibrillation Who Undergo Catheter Ablation Therapy
Janssen Scientific Affairs
NCT01729871
Eliminate Thromboembolism: Improving Anticoagulation in Non-valvular Atrial Fibrillation Patients
Duke University
NCT02461602
Atrial Fibrillation Screening in Nursing Homes
State University of New York at Buffalo
NCT03860246
STOP AF First: Cryoballoon Catheter Ablation in an Antiarrhythmic Drug Naive Paroxysmal Atrial Fibrillation
Medtronic Cardiac Ablation Solutions
NCT03118518
Study of RSD1235-SR for the Prevention of Atrial Fibrillation/Atrial Flutter Recurrence
Advanz Pharma
NCT00267930
Management of Gastrointestinal and Urogenital (GI/GU) Bleedings in Atrial Fibrillation Patients Using Pradaxa
Boehringer Ingelheim
NCT02022020
QT Variability Pre and Post Cardioversion
Vanderbilt University
NCT00885391
A Genomic Approach to Warfarin Dose Prescription in Admixed Caribbean Hispanics
University of Puerto Ri
NCT02345356
Evaluating the Effectiveness of Fish Oil Supplements at Reducing the Recurrence of Atrial Fibrillation
Vanderbilt University
NCT00552084
STOP Persistent AF
Medtronic Cardiac Ablation Solutions
NCT03012841
Effect of Amiodarone on the Procedure Outcome in Long-standing Persistent Atrial Fibrillation Undergoing Pulmonary Vein Antral Isolation
Texas Cardiac Arrhythmia Research Foundation
NCT01173809
Early Detection and Treatment of Esophageal Injury After Catheter Ablation for Atrial Fibrillation
University of Oklahoma
NCT00584922
Safety and Efficacy of CryoCor™ Cryoablation for PAF
Boston Scientific Corporation
NCT00231296
Effect of Catheter Ablation on Clinical Course of Migraine in AF Patients With or Without Previous History of Migraine
Texas Cardiac Arrhythmia Research Foundation
NCT01391091
Study Watch Atrial Fibrillation (AF) Detection Investigation
Verily Life Sciences
NCT04074434
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 7 |
| Phase 2 | 12 |
| Phase 3 | 26 |
| Phase 4 | 19 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Atrial Fibrillation Trial Landscape
204 indexed Atrial Fibrillation studies · 60 recruiting (29%).
Phase mix: 45 late (III/IV) vs 19 early (I/II).
Top sponsor: The Cleveland Clinic (9 trials), 9 others listed. 50 shown below, recruiting first.
How to read this condition's trial landscape
That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Atrial Fibrillation?
PlainTrial tracks 204 US clinical trials for Atrial Fibrillation, of which 60 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Atrial Fibrillation?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology - how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.