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NCT06005740 · ClinicalTrials.gov registry record · Phase 1
A Phase 1, First in Human Study of TORL-4-500 in Patients With Advanced Cancer
A Phase 1 study of Advanced Solid Tumor and Hepatocellular Carcinoma, sponsored by TORL Biotherapeutics.
- Recruiting
- Registry status
- Phase 1
- Development phase
- 70
- Enrollment target
- 10
- Study locations
NCT06005740: Recruiting Phase 1 study of Advanced Solid Tumor and Hepatocellular Carcinoma, sponsored by TORL Biotherapeutics.
NCT06005740 is a Phase 1 study of Advanced Solid Tumor and Hepatocellular Carcinoma that is actively recruiting participants, run by TORL Biotherapeutics. The registered enrollment target is 70 participants, below the 193-participant average among 189 other Advanced Solid Tumor trials with a reported enrollment target (64% lower). The trial reports 10 study locations across 7 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06005740, a Phase 1 study of Advanced Solid Tumor and Hepatocellular Carcinoma, is actively recruiting participants, sponsored by TORL Biotherapeutics.
- RECRUITING
- Registry status
- Phase 1
- Development phase
- 70 participants
- Enrollment target
- 10
- Study locations
Study Summary
This first-in-human study will evaluate the safety, tolerability, pharmacokinetics, and antitumor activity of TORL-4-500 in patients with advanced cancer. For Part 1, any advanced or metastatic solid tumor malignancy will be evaluated including, for example, adrenocortical carcinoma (ACC).
Primary Outcome
Incidence and severity of adverse events, serious adverse events, according to NCI-CTCAE Version 5.0
Conditions Studied
Interventions
- DRUG TORL-4-500
Study Locations (10)
California
- Providence Medical Foundation - Fullerton
- UCLA - JCCC Clinical Research Unit - Los Angeles
- Torrance Memorial Physician Network - Torrance
Florida
- Mayo Clinic Jacksonville - Jacksonville
- Florida Cancer Specialists Lake Nona Drug Development Unit - Orlando
Arizona
- Mayo Clinic Phoenix - Phoenix
Minnesota
- Mayo Clinic Rochester - Rochester
Virginia
- Virginia Cancer Specialists - Lexington
Ontario
- University Health Network, Princess Margaret Cancer Centre - Toronto
Quebec
- McGill University Health Centre - Montreal
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 70 participants |
| Start Date | 2023-12-04 |
| Est. Completion | 2026-10-31 |
| Phase | Phase 1 |
What NCT06005740 shows while recruiting
NCT06005740 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 70 participants, a relatively small participant target, below the 193-participant average among 189 other Advanced Solid Tumor trials with a reported enrollment target (64% lower).
The record links to 2 conditions, with Advanced Solid Tumor appearing as the primary indexed condition, and to 1 intervention - of which TORL-4-500 is the first listed.
NCT06005740 lists 10 locations in 7 states (California, Florida, Arizona).
Frequently Asked Questions
What is clinical trial NCT06005740 about?
NCT06005740 is a clinical study titled "A Phase 1, First in Human Study of TORL-4-500 in Patients With Advanced Cancer". This first-in-human study will evaluate the safety, tolerability, pharmacokinetics, and antitumor activity of TORL-4-500 in patients with advanced cancer. For Part 1, any advanced or metastatic solid tumor malignancy will be evaluated including, for example, adrenocortical carcinoma (ACC).
What is the current status of trial NCT06005740?
This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 70 participants. The study started on 2023-12-04. Estimated completion is 2026-10-31.
What conditions does trial NCT06005740 study?
This clinical trial studies the following conditions: Advanced Solid Tumor, Hepatocellular Carcinoma.
What interventions are being tested in trial NCT06005740?
The interventions under investigation include: TORL-4-500 (DRUG).
Who is sponsoring clinical trial NCT06005740?
This trial is sponsored by TORL Biotherapeutics, which has 8 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06005740 being conducted?
This trial has 10 study locations across Arizona, California, Florida, Minnesota, Virginia. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Advanced Solid Tumor
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT06005740's enrollment target sits among peer trials
70 142nd of 189 higher than 42 of 189 other Advanced Solid Tumor trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Advanced Solid Tumor trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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