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RECRUITING Phase 1

An Engineered Sirpα Fused to Anti-Pd-L1 And Tgf-β Fusion Protein (HCB301) in Subjects With Selected Advanced Tumors

NCT06487624 · View on ClinicalTrials.gov ↗

Study Summary

The purpose of this study is to find out whether IV injection of HCB301 is an effective treatment for different types of advanced solid tumors and relapsed and refractory classical Hodgkin lymphomas and what side effects (unwanted effects) may occur in subjects aged 18 years old and above.

Interventions

  • DRUG HCB301

Study Locations (6)

Other

  • The First Affiliated Hospital, Zhejiang University School of Medicine — Hangzhou
  • Zhejiang Provincial Cancer Hospital — Hangzhou
  • Xuzhou Central Hospital — Xuzhou
  • Yantai Yuhuangding Hospital — Yantai
  • Southern Medical University Zhujiang Hospital — Zhujiang

South Carolina

  • Prisma Health-Upstate — Greenville

Trial Details

FieldValue
Enrollment Target 50 participants
Start Date 2025-04-02
Est. Completion 2027-05-31
Phase Phase 1

Sponsor

FBD Biologics Limited

2 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT06487624

The ClinicalTrials.gov registry entry for NCT06487624 describes a study currently listed as recruiting. It is categorized as Phase 1, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 50 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is FBD Biologics Limited, which has 2 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 2 conditions, with Advanced Solid Tumor appearing as the primary indexed condition, and to 1 intervention — of which HCB301 is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT06487624 reports 6 study locations spanning 2 distinct geographic areas — top geographies include Other, South Carolina. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT06487624 about?

NCT06487624 is a clinical study titled "An Engineered Sirpα Fused to Anti-Pd-L1 And Tgf-β Fusion Protein (HCB301) in Subjects With Selected Advanced Tumors". The purpose of this study is to find out whether IV injection of HCB301 is an effective treatment for different types of advanced solid tumors and relapsed and refractory classical Hodgkin lymphomas and what side effects (unwanted effects) may occur in subjects aged 18 years old and above.

What is the current status of trial NCT06487624?

This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 50 participants. The study started on 2025-04-02. Estimated completion is 2027-05-31.

What conditions does trial NCT06487624 study?

This clinical trial studies the following conditions: Advanced Solid Tumor, Refractory Hodgkin Lymphoma. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT06487624?

The interventions under investigation include: HCB301 (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT06487624?

This trial is sponsored by FBD Biologics Limited, which has 2 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT06487624 being conducted?

This trial has 6 study locations across South Carolina. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial