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NCT05163041 · ClinicalTrials.gov registry record · Phase 1

Study BT7480-100 in Patients With Advanced Malignancies Associated With Nectin-4 Expression

A Phase 1 study of Advanced Solid Tumor, sponsored by BicycleTx Limited.

Active
Registry status
Phase 1
Development phase
200
Enrollment target
9
Study locations

NCT05163041 is a Phase 1 study of Advanced Solid Tumor that is active but no longer recruiting, run by BicycleTx Limited. The registered enrollment target is 200 participants, roughly in line with the 192-participant average among 189 other Advanced Solid Tumor trials with a reported enrollment target. The trial reports 9 study locations across 8 states.

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The verdict

NCT05163041, a Phase 1 study of Advanced Solid Tumor, is active but no longer recruiting, sponsored by BicycleTx Limited.

ACTIVE NOT RECRUITING
Registry status
Phase 1
Development phase
200 participants
Enrollment target
9
Study locations

Study Summary

This clinical study is evaluating a drug called BT7480 alone and in combination with nivolumab in participants with advanced solid tumors associated with Nectin-4 expression. The main goals of the study are to: * Find the recommended dose of BT7480 that can be given safely to participants alone and in combination with nivolumab * Learn about the side effects and effectiveness of BT7480 alone and in combination with nivolumab * Learn about the effect BT7480 has on the body and how BT7480 is cleared by the body * Learn about the side effects and effectiveness of BT7480 in patients with reduced kidney function

Conditions Studied

Advanced Solid Tumor

Interventions

  • DRUG Nivolumab
  • DRUG BT7480

Study Locations (9)

Texas

  • MD Anderson Cancer Center - Houston
  • START Center for Cancer Care - San Antonio

Iowa

  • State University of Iowa - Iowa City

New York

  • Columbia University Irving Medical Center - New York

Ohio

  • University Hospitals Cleveland Medical Center - Cleveland

Pennsylvania

  • Fox Chase Cancer Center - Philadelphia

Virginia

  • Virginia Cancer Specialists - Fairfax

Surrey

  • The Royal Marsden NHS Foundation Trust - Sutton

Other

  • The Beatson West of Scotland Cancer Centre - Glasgow

Trial Details

FieldValue
Enrollment Target 200 participants
Start Date 2021-11-02
Est. Completion 2026-12
Phase Phase 1

Sponsor

BicycleTx Limited

7 total trials

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What the Registry Record Tells You About NCT05163041

The ClinicalTrials.gov registry entry for NCT05163041 describes a study currently listed as active not recruiting, categorized as Phase 1. The registered enrollment target is 200 participants, a figure that helps gauge the scale of data the investigators plan to collect, roughly in line with the 192-participant average among 189 other Advanced Solid Tumor trials with a reported enrollment target. The listed sponsor is BicycleTx Limited, which has 7 total studies on file at ClinicalTrials.gov.

The record links to 1 condition, with Advanced Solid Tumor appearing as the primary indexed condition, and to 2 interventions - of which Nivolumab is the first listed.

NCT05163041 reports 9 study locations spanning 8 distinct geographic areas - top geographies include Texas, Iowa, New York.

Frequently Asked Questions

What is clinical trial NCT05163041 about?

NCT05163041 is a clinical study titled "Study BT7480-100 in Patients With Advanced Malignancies Associated With Nectin-4 Expression". This clinical study is evaluating a drug called BT7480 alone and in combination with nivolumab in participants with advanced solid tumors associated with Nectin-4 expression. The main goals of the study are to: * Find the recommended dose of BT7480 that can be given safely to participants alone an...

What is the current status of trial NCT05163041?

This trial is currently active not recruiting. It is a Phase 1 study. The enrollment target is 200 participants. The study started on 2021-11-02. Estimated completion is 2026-12.

What conditions does trial NCT05163041 study?

This clinical trial studies the following conditions: Advanced Solid Tumor.

What interventions are being tested in trial NCT05163041?

The interventions under investigation include: Nivolumab (DRUG), BT7480 (DRUG).

Who is sponsoring clinical trial NCT05163041?

This trial is sponsored by BicycleTx Limited, which has 7 total clinical trials registered on ClinicalTrials.gov.

Where is trial NCT05163041 being conducted?

This trial has 9 study locations across Iowa, New York, Ohio, Pennsylvania, Texas. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

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Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page mirrors this trial's own ClinicalTrials.gov registry record, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.