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ClinicalTrials.gov 133 recruiting now official registry

Advanced Solid Tumor clinical trials

133 of 190 indexed Advanced Solid Tumor trials are currently recruiting.

190 US clinical trials · 133 currently recruiting

Advanced Solid Tumor is the subject of 190 registered US clinical trials on ClinicalTrials.gov, 133 of them currently open to new participants. 0 are in Phase 3-4 (later-stage) and 186 in Phase 1-2 (earlier-stage). The most active sponsor is Daiichi Sankyo, running 7 of these trials.

The research picture

Advanced Solid Tumor has 190 registered US clinical trials, 133 of them open to new participants right now, about 70% of the total.

133
recruiting participants now
70%
of trials open to enrollment
0
in Phase 3–4 (later-stage)
7
top sponsor: Daiichi Sankyo
Phase 1180Phase 26

Active & Recent Trials

190 total, page 4 of 4

ACTIVE NOT RECRUITING Phase 1 157 participants

BGB-15025 Alone and in Combination With Anti-PD-1 Monoclonal Antibody Tislelizumab in Participants With Advanced Solid Tumors

BeiGene

NCT04649385

ACTIVE NOT RECRUITING Phase 1 150 participants

Dose Escalation and Expansion Study of WTX-124 as Monotherapy and in Combination With Pembrolizumab (Pembro) in Patients With Selected Advanced or Metastatic Solid Tumors

Werewolf Therapeutics

NCT05479812

ACTIVE NOT RECRUITING Phase 1 144 participants

A Phase 1/2 Study of Inlexisertib (DCC-3116) in Patients With RAS/MAPK Pathway Mutant Solid Tumors

Deciphera Pharmaceuticals

NCT04892017

ACTIVE NOT RECRUITING Phase 1 141 participants

M9466 Alone or in Combination in Advanced Solid Tumors (DDriver 501)

EMD Serono Research & Development Institute

NCT06421935

ACTIVE NOT RECRUITING Phase 1 132 participants

Study Of ATRN-119 In Patients With Advanced Solid Tumors

Aprea Therapeutics

NCT04905914

ACTIVE NOT RECRUITING Phase 1 125 participants

A Study of DSP107 Alone and in Combination with Atezolizumab for Patients with Advanced Solid Tumors

Kahr Medical

NCT04440735

ACTIVE NOT RECRUITING Phase 1 123 participants

Study of RP3 Monotherapy and RP3 in Combination With Nivolumab in Patients With Solid Tumours

Replimune

NCT04735978

ACTIVE NOT RECRUITING Phase 1 120 participants

A First-in-Human Study of BGB-C354 Alone and in Combination With Tislelizumab in Participants With Advanced Solid Tumors

BeiGene

NCT06422520

ACTIVE NOT RECRUITING Phase 1 117 participants

A Phase 1/2 Study of OBI-992 in Subjects With Advanced Solid Tumors

OBI Pharma

NCT06480240

ACTIVE NOT RECRUITING Phase 1 98 participants

A Study of SNS-101 (Anti VISTA) Monotherapy and in Combination With Cemiplimab in Patients With Advanced Solid Tumors

Sensei Biotherapeutics

NCT05864144

ACTIVE NOT RECRUITING Phase 1 95 participants

Study of TPX-0022 in Patients With Advanced NSCLC, Gastric Cancer or Solid Tumors Harboring Genetic Alterations in MET

Turning Point Therapeutics

NCT03993873

ACTIVE NOT RECRUITING Phase 1 78 participants

A Study of DS-1103a Combination Therapy in Participants With Advanced Solid Tumors

Daiichi Sankyo

NCT05765851

ACTIVE NOT RECRUITING Phase 1 78 participants

Less Frequent IV Dosing & Tumor Microenvironment (TME) Study of Nemvaleukin Alfa (ALKS 4230) Monotherapy and in Combination With Pembrolizumab (ARTISTRY-3)

Mural Oncology

NCT04592653

ACTIVE NOT RECRUITING Phase 1 70 participants

First in Human Study of TORL-3-600 in Participants With Advanced Cancer

TORL Biotherapeutics

NCT05948826

ACTIVE NOT RECRUITING Phase 1 70 participants

First in Human Study of TORL-2-307-MAB in Participants With Advanced Cancer

TORL Biotherapeutics

NCT05159440

ACTIVE NOT RECRUITING Phase 1 45 participants

A Phase 1 Clinical Study of NXP800 in Subjects With Advanced Cancers and Expansion in Subjects With Ovarian Cancer

Nuvectis Pharma

NCT05226507

ACTIVE NOT RECRUITING Phase 1 44 participants

CFI-402257, a Potent and Selective TTK Inhibitor, in Solid Tumors and With Fulvestrant in Breast Cancer

Treadwell Therapeutics

NCT05251714

ACTIVE NOT RECRUITING Phase 1 42 participants

Phase 1 Study of SON-1010 in Adult Patients With Advanced Solid Tumors

Sonnet BioTherapeutics

NCT05352750

ACTIVE NOT RECRUITING Phase 1 39 participants

A Phase I Study, Evaluating the Safety, Pharmacokinetics and Efficacy of PRJ1-3024 in Subjects With Advanced Solid Tumors

Zhuhai Yufan Biotechnologies Co.

NCT05159700

ACTIVE NOT RECRUITING Phase 1 37 participants

Lurbinectedin With Berzosertib, an ATR Kinase Inhibitor in Small Cell Cancers and High-Grade Neuroendocrine Cancers

National Cancer Institute (NCI)

NCT04802174

ACTIVE NOT RECRUITING Phase 1 23 participants

A Phase 1/2 Study of GEN1286 in Patients With Advanced Solid Tumors

Genmab

NCT06685068

ACTIVE NOT RECRUITING Phase 1 18 participants

Niraparib and Neratinib in Advanced Solid Tumors With Expansion Cohort in Advanced Ovarian Cancer

Virginia Commonwealth University

NCT04502602

ACTIVE NOT RECRUITING Phase 1 16 participants

Study of TTX-MC138 in Subjects With Advanced Solid Tumors

TransCode Therapeutics

NCT06260774

ACTIVE NOT RECRUITING Phase 1 15 participants

A Phase 1/2 Study of KSQ-001EX, Autologous Tumor Infiltrating Lymphocytes Engineered to Inactivate the SOCS1 Gene, in Patients With Select Advanced Solid Tumors

M.D. Anderson Cancer Center

NCT06237881

ACTIVE NOT RECRUITING Phase 1 15 participants

Phase IB Metformin, Digoxin, Simvastatin in Solid Tumors

Danae Hamouda, MD

NCT03889795

ACTIVE NOT RECRUITING Phase 2 8 participants

Study of Rituximab or Tocilizumab for Patients With Steroid-Dependent Immune-Related Adverse Events (irAEs)

Columbia University

NCT04375228

COMPLETED Phase 1 258 participants

A Study of NB003 in Patients With Advanced Malignancies

Ningbo Newbay Technology Development Co.

NCT04936178

COMPLETED Phase 1 204 participants

Safety and Preliminary Effectiveness of BGB-A445 in Combination With Tislelizumab in Participants With Advanced Solid Tumors

BeiGene

NCT04215978

COMPLETED Phase 1 105 participants

A Study of SY 5609, a Selective CDK7 Inhibitor, in Advanced Solid Tumors

Syros Pharmaceuticals

NCT04247126

COMPLETED Phase 1 95 participants

XTX202 in Patients With Advanced Solid Tumors

Xilio Development

NCT05052268

COMPLETED Phase 1 86 participants

A Study of PRT811 in Participants With Advanced Solid Tumors, CNS Lymphoma and Gliomas

Prelude Therapeutics

NCT04089449

COMPLETED Phase 1 78 participants

A Phase 1a/b Study of IK-175 as a Single Agent and in Combination With Nivolumab in Patients With Locally Advanced or Metastatic Solid Tumors and Urothelial Carcinoma

Ikena Oncology

NCT04200963

COMPLETED Phase 1 44 participants

Study of BMS-986315 Alone and in Combination With Nivolumab or Cetuximab in Participants With Advanced Solid Tumors

Bristol-Myers Squibb

NCT04349267

COMPLETED Phase 1 42 participants

Oral Administration of STC-15 in Subjects With Advanced Malignancies

STORM Therapeutics

NCT05584111

COMPLETED Phase 1 29 participants

JAB-21822 Activity in Adult Patients With Advanced Solid Tumors Harboring KRAS G12C Mutation

Jacobio Pharmaceuticals Co.

NCT05002270

COMPLETED Phase 1 22 participants

Study of AGEN1571 in Participants With Advanced Solid Tumors

Agenus

NCT05377528

COMPLETED Phase 1 15 participants

First-in-Human Study of the Safety, Tolerability, and Pharmacokinetic/Pharmacodynamic Profile of VX-984 in Combination With Chemotherapy

EMD Serono Research & Development Institute

NCT02644278

COMPLETED Phase 2 15 participants

Ivosidenib (AG-120) With Nivolumab in IDH1 Mutant Tumors

Jason J. Luke, MD

NCT04056910

COMPLETED Phase 1 15 participants

Phase 1b Study to Investigate the Safety and Maximum Tolerated Dose of Aldoxorubicin (INNO-206) Plus Doxorubicin HCL in Subjects With Advanced Solid Tumors

ImmunityBio

NCT01673438

COMPLETED Phase 1 8 participants

A Study of ES002023 (Anti-CD39 Antibody) in Patients With Locally Advanced or Metastatic Solid Tumors

Elpiscience Biopharma

NCT05075564

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Phase Distribution

PhaseTrial count
Phase 1 180
Phase 2 6

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Advanced Solid Tumor Trial Landscape

190 indexed Advanced Solid Tumor studies · 133 recruiting (70%).

Phase mix: 0 late (III/IV) vs 186 early (I/II).

Top sponsor: Daiichi Sankyo (7 trials), 9 others listed. 40 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Advanced Solid Tumor?

PlainTrial tracks 190 US clinical trials for Advanced Solid Tumor, of which 133 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Advanced Solid Tumor?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.