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A Study of GRC 54276 in Participants With Advanced Solid Tumors and Lymphomas.
NCT05878691 · View on ClinicalTrials.gov ↗
Study Summary
This is first in human (FIH) study to a) evaluate the safety and tolerability profile of GRC54276, b) determine the maximum tolerated dose (MTD) and recommended Phase 2 doses (RP2D), and c) pharmacokinetic profile of GRC54276 alone and in combination with pembrolizumab or atezolizumab in participants with advanced solid tumors and lymphomas.
Conditions Studied
Interventions
- DRUG GRC 54276
- DRUG GRC 54276 + Pembrolizumab
- DRUG GRC 54276 + Atezolizumab
Study Locations (18)
Maharashtra
- Krupamayi Hospitals — Aurangabad
- PD Hinduja Hospital and Medical Research Centre — Mumbai
- HCG Manavata Cancer Centre — Nashik
- Sankalp Hospital — Nashik
- Bhaktivedanta Hospital and Research Institute — Thane
Karnataka
- Health Care Global Enterprises Ltd (HCG) — Bangalore
- Vydehi Hospital — Bangalore
- Cytecare Hospitals Pvt Ltd. — Bengaluru
- Aster CMI Hospital — Bengaluru
Andhra Pradesh
- Hcg City Cancer Centre — Vijayawada
- Mahatma Gandhi Cancer Hospital and Research Institute — Visakhapatnam
Telangana
- AIG Hospitals, (A unit of asian Institute of Gastroenterology) — Hyderabad
- Basavatarakam Indo American Cancer Hospital Research Institute — Hyderabad
North Carolina
- Carolina BioOncology Institute — Huntersville
Wisconsin
- Froedtert & Medical College of Wisconsin - Froedtert Hospital - Clinical Cancer Center — Milwaukee
Haryana
- Artemis Hospital — Gurgaon
Kerala
- Malabar Cancer Centre — Kannur
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 320 participants |
| Start Date | 2022-06-28 |
| Est. Completion | 2027-07-30 |
| Phase | Phase 1 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT05878691
The ClinicalTrials.gov registry entry for NCT05878691 describes a study currently listed as active not recruiting. It is categorized as Phase 1, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 320 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Glenmark Specialty S.A., which has 4 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 2 conditions, with Lymphoma appearing as the primary indexed condition, and to 3 interventions — of which GRC 54276 is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT05878691 reports 18 study locations spanning 9 distinct geographic areas — top geographies include Maharashtra, Karnataka, Andhra Pradesh. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT05878691 about?
NCT05878691 is a clinical study titled "A Study of GRC 54276 in Participants With Advanced Solid Tumors and Lymphomas.". This is first in human (FIH) study to a) evaluate the safety and tolerability profile of GRC54276, b) determine the maximum tolerated dose (MTD) and recommended Phase 2 doses (RP2D), and c) pharmacokinetic profile of GRC54276 alone and in combination with pembrolizumab or atezolizumab in participant...
What is the current status of trial NCT05878691?
This trial is currently active not recruiting. It is a Phase 1 study. The enrollment target is 320 participants. The study started on 2022-06-28. Estimated completion is 2027-07-30.
What conditions does trial NCT05878691 study?
This clinical trial studies the following conditions: Lymphoma, Advanced Solid Tumor. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT05878691?
The interventions under investigation include: GRC 54276 (DRUG), GRC 54276 + Pembrolizumab (DRUG), GRC 54276 + Atezolizumab (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT05878691?
This trial is sponsored by Glenmark Specialty S.A., which has 4 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT05878691 being conducted?
This trial has 18 study locations across North Carolina, Wisconsin, Andhra Pradesh, Haryana, Karnataka. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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