Yale University

Open enrollment with an early-phase pipeline tilt

According to ClinicalTrials.gov-derived indexes, Yale University sits in the top decile of US sponsors by registered trial count (#13 of 15,742 sponsors by registered trial count).

1,492 total trials 254 currently recruiting 1005 completed early-phase tilt top decile by trial count

Yale University: 1,492 sponsored US clinical trials, 254 recruiting.

Yale University sponsors 1,492 registered US clinical trials on ClinicalTrials.gov, 254 of them currently recruiting, and 1,005 completed. 99 of these trials are in Phase 3-4 (later-stage) and 579 in Phase 1-2 (earlier-stage). The most-studied condition in this pipeline is Opioid Use Disorder, with 19 trials.

Top-decile sponsor footprint

Yale University ranks in the top decile of sponsors by registered trial count (#13 of 15,742 sponsors by registered trial count). Volume at this scale usually reflects a long institutional pipeline, read phase tilt and therapeutic areas below before treating it as current-year activity.

Trial completion reliability score

D 60/100

1,005 of 1,138 decided trials (Completed vs. Terminated on ClinicalTrials.gov) reached their planned completion (88.3%), vs. national p10 68.4% / p90 100% among 1,234 sponsors with at least 10 decided trials. Still-open trials (Recruiting, Active-not-recruiting, Not-yet-recruiting) are excluded since they have not reached an outcome yet.

Open and recent trials

1,492 total, page 4 of 30

RECRUITING Early Phase 1

Addictive Threshold of Nicotine

NCT06096714

RECRUITING

The Society for Obstetric Anesthesia and Perinatology Research Network General Anesthesia Registry

NCT06030063

RECRUITING NA

SGM Evidenced-Based Mental Healthcare Implementation

NCT05890404

RECRUITING Phase 2

Efficacy of Valbenazine for the Treatment of Trichotillomania in Adults

NCT05207085

RECRUITING Phase 1

Greater Occipital Nerve Blockade in Veterans With Post-concussion Headache: Sub-study 1

NCT06069791

RECRUITING

Evaluating the Unmet Needs of Older Adults to Promote Functional Recovery After a Critical Illness

NCT06006000

RECRUITING Early Phase 1

Intradermal Influenza Vaccination

NCT06067555

RECRUITING

The OBSERVE Protocol

NCT06725277

RECRUITING NA

Father-Focused Intervention for Reducing Family Violence and Symptoms in Children

NCT06074068

RECRUITING Phase 2

Pregnenolone for the Treatment of Alcohol Use Disorder

NCT05781009

RECRUITING Phase 2

Trial Of Stereotactic Body Radiation Therapy (SBRT) for Oligoprogression on Immune Checkpoint Inhibitors (ICI) in Metastatic Renal Cell Carcinoma

NCT04974671

RECRUITING Phase 2

Sipuleucel-T Combined With Bipolar Androgen Therapy in Men With mCRPC

NCT06100705

RECRUITING Phase 1

AMPK-activation by Metformin in FSGS: AMP-FSGS

NCT06090227

RECRUITING Phase 1

Physiologic Markers of Cardiometabolic Risk in People With Type 1 Diabetes

NCT06105931

RECRUITING Phase 1

Supporting Parents in Affirming Their Children's Experiences of Stigma

NCT05919849

RECRUITING Early Phase 1

Investigating the Mu:Kappa Opioid Receptor Imbalance in Alcohol Use Disorder

NCT05957159

RECRUITING Phase 2

Off-Label Medications for Alcohol Use Disorder Among Patients With HIV: Pilot Study 1

NCT06004830

RECRUITING Phase 2

Systems Investigation of Vaccine Responses in Aging and Frailty

NCT05291676

RECRUITING Early Phase 1

PK/PD of Oral and Vaporized Delta-9-Tetrahydrocannabinol (THC) in Older Adults

NCT05906511

RECRUITING NA

Point-of-care Ultrasound and Treatment Disparities for Left Ventricular Hypertrophy

NCT05730309

RECRUITING NA

Mechanisms of Ultrasound Neuromodulation Effects in Diabetes

NCT06042517

RECRUITING Phase 2

Empagliflozin in Patients With Cirrhosis and Ascites

NCT05726032

RECRUITING Phase 1

Alpha-Amino-3-Hydroxy-5-Methyl-4- Isoxazole Propionic Acid Receptor Components of the Anti-Depressant Ketamine Response

NCT05915013

RECRUITING Phase 2

Enhancing Week-long Psychological Treatment for PTSD With Ketamine

NCT05737693

RECRUITING Phase 1

Mechanisms of Diuretic Resistance in Heart Failure, Aim 2

NCT05753059

RECRUITING NA

Expanding Medication-Assisted Therapies in Central Asia

NCT05579470

RECRUITING Phase 1

Effects of Acute and Chronic Empagliflozin Heart Failure

NCT05553938

RECRUITING Phase 4

Integrated e-Health (Electronic Health) for HIV and Substance Use Disorders in Justice Involved Women

NCT05547048

RECRUITING Phase 2

Semaglutide Effects in Obese Youth With Prediabetes/New Onset Type 2 Diabetes and Non-Alcoholic Fatty Liver Disease

NCT05067621

RECRUITING Phase 2

Pembrolizumab and Brentuximab Vedotin in Subjects With Relapsed/Refractory T-cell Lymphoma

NCT05313243

RECRUITING NA

Stepped Care for Patients to Optimize Whole Recovery

NCT05155163

RECRUITING NA

Acute Effects of Focused Ultrasound Modulation on EEG Behavior in Status Epilepticus Patients

NCT05784805

RECRUITING NA

Trauma-informed Approach to Timely Detection and Management of Early Postpartum Hypertension

NCT05884190

RECRUITING Phase 2

A Study of Sacituzumab Govitecan (IMMU-132) in Patients With Recurrent or Persistent Cervical Cancer

NCT05838521

RECRUITING

An Evaluation of Hip Preservation Outcomes

NCT05746533

RECRUITING Phase 1

SV2A & TSPO PET Imaging Measures to Reveal Mechanisms of HIV Neuropathogenesis During Antiretroviral Therapy

NCT05586581

RECRUITING Phase 4

LIVEBETTER: A Trial Comparing Medications in Older Adults With Stable Angina and Multiple Chronic Conditions

NCT05786417

RECRUITING

Social Disconnection Study

NCT06705348

RECRUITING

SHAPE Test for Preoperative Risk Stratification

NCT05743673

RECRUITING NA

Trial of Exercise and Lifestyle for Women With Ovarian and Endometrial Cancer

NCT05761561

RECRUITING Phase 2

The Impact of AMPA Receptor Blockade on Ketamine's Anti-Suicidal Effects

NCT05786066

RECRUITING Phase 1

OMAR Opioid Use Disorder

NCT05683184

RECRUITING Phase 4

Effect of Empagliflozin on Peritoneal and Kidney Function in End Stage Renal Disease

NCT05671991

RECRUITING NA

Immunometabolic Mechanisms of Blood Flow Restriction (BFR) Training After Anterior Cruciate Ligament Reconstruction

NCT05012982

RECRUITING Phase 2

Yale Steroid Enhanced Versus Exparel Nerveblock TKA Part 2

NCT05736549

RECRUITING NA

Affirmative Psychotherapy for Sexual Minority Women's Mental and Behavioral Health

NCT05509166

RECRUITING NA

TRUsted rEsidents and Housing Assistance to Decrease Violence Exposure in New Haven

NCT05723614

RECRUITING NA

Neuroplasticity in Maternal Opioid Use Disorder (OUD)

NCT05495984

RECRUITING NA

Ultrasound Effects on Glycemic Control in T2DM

NCT05354947

RECRUITING NA

Neurofeedback From the Supplementary Motor Area for Tourette Syndrome

NCT05558566

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Phase Distribution

PhaseTrial count
Phase 1 312
Phase 2 267
Phase 3 52
Phase 4 47

What is open in the Yale University pipeline

254 recruiting of 1,492 indexed (17% open); 1,005 completed (67%).

Phase mix: 99 late (III/IV) vs 579 early (I/II) (early-phase heavy).

Top condition: Opioid Use Disorder (19 trials), 9 others listed.

How open-pipeline share is computed

Recruiting share is recruiting_count divided by trial_count for this sponsor in the public registry export. Status can change between pulls; treat the figure as a research-attention snapshot, not product availability.

Yale University: open-pipeline peers nationwide

Peers matched on 1,492 registered trials and 17% open enrollment, not the therapeutic-area sidebar.

Yale University sits at or above the median trial volume and at or above the median recruiting share among these 9 nationwide peers -- the two do not always move together. Source: ClinicalTrials.gov (2026-08-08 snapshot). 2×2 strategic matrix plotting 9 entities by Total trials (X) and Recruiting share (Y), with a crosshair dividing the plot into four quadrants. Higher volume & more openFocused & more openHigher volume, mostly closedSmaller & mostly closed 05001,0001,5002,000 5%10%15%20% Total trials Recruiting share Yale UniversityWashington University School of MedicineJohns Hopkins UniversityUniversity of PennsylvaniaNovartis PharmaceuticalsNYU Langone HealthCSL BehringPenn State UniversityUniversity of Hawaii
Yale University sits at or above the median trial volume and at or above the median recruiting share among these 9 nationwide peers -- the two do not always move together. Source: ClinicalTrials.gov (2026-08-08 snapshot).

Yale University sits at or above the median trial volume and at or above the median recruiting share among these 9 nationwide peers -- the two do not always move together.

Sponsors near 1,492 trials (± recruiting share)

Sponsors near 17% open enrollment (± trial volume)

What to do with this Yale University page

1,492 registered trials is a research-attention snapshot, not an endorsement of Yale University or any single study.

  • 254 of Yale University's trials are currently recruiting, check each one's own eligibility criteria before contacting a site. Browse recruiting trials
  • Opioid Use Disorder is the condition Yale University studies most, compare against other sponsors active in the same condition before evaluating a specific study. See Opioid Use Disorder trials
  • Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide

Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.

Yale University pipeline card: 1,492 registered trials from official public datasets.Report a data error.