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NCT06105931 · ClinicalTrials.gov registry record · Phase 1
Physiologic Markers of Cardiometabolic Risk in People With Type 1 Diabetes
A Phase 1 study of Obesity and Type 1 Diabetes, sponsored by Yale University.
- Recruiting
- Registry status
- Phase 1
- Development phase
- 15
- Enrollment target
- 1
- Study location
NCT06105931: Recruiting Phase 1 study of Obesity and Type 1 Diabetes, sponsored by Yale University.
NCT06105931 is a Phase 1 study of Obesity and Type 1 Diabetes that is actively recruiting participants, run by Yale University. The registered enrollment target is 15 participants, below the 819-participant average among 1,053 other Obesity trials with a reported enrollment target (98% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06105931, a Phase 1 study of Obesity and Type 1 Diabetes, is actively recruiting participants, sponsored by Yale University.
- RECRUITING
- Registry status
- Phase 1
- Development phase
- 15 participants
- Enrollment target
- 1
- Study location
Study Summary
More than 40% of young adults with type 1 diabetes (T1D) also have overweight or obesity. Each of these diagnoses increase the risk of adverse cardiovascular events. Investigators aim to obtain reference data for individuals with T1D who do not have overweight obesity, to understand how close GLP-1 analogue obesity treatment in those with overweight/obesity brings physiologic markers of cardiometabolic risk to those with BMI in the normal range. Specifically, investigators will describe how drivers of gluconeogenesis and lipemia (specifically measured as visceral fat ratio, insulin resistance, and postprandial lipemia,) that contribute to cardiometabolic risk in T1D change over time.
Primary Outcome
Measured as VAT/Subcutaneous Adipose Tissue + VAT changes over 1 year in young adults with T1D and body mass index \<25kg/m2.
Conditions Studied
Interventions
- BIOLOGICAL Hyperinsulinemic-euglycemic clamp
- OTHER High Fat Mixed Meal Tolerance Test
Study Locations (1)
Connecticut
- Yale Pediatric Diabetes Research - New Haven
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 15 participants |
| Start Date | 2023-12-13 |
| Est. Completion | 2028-06 |
| Phase | Phase 1 |
What NCT06105931 shows while recruiting
NCT06105931 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 15 participants, a relatively small participant target, below the 819-participant average among 1,053 other Obesity trials with a reported enrollment target (98% lower).
The record links to 2 conditions, with Obesity appearing as the primary indexed condition, and to 2 interventions - of which Hyperinsulinemic-euglycemic clamp is the first listed.
NCT06105931 reports a single indexed study location in Connecticut.
Frequently Asked Questions
What is clinical trial NCT06105931 about?
NCT06105931 is a clinical study titled "Physiologic Markers of Cardiometabolic Risk in People With Type 1 Diabetes". More than 40% of young adults with type 1 diabetes (T1D) also have overweight or obesity. Each of these diagnoses increase the risk of adverse cardiovascular events. Investigators aim to obtain reference data for individuals with T1D who do not have overweight obesity, to understand how close GLP-1 ...
What is the current status of trial NCT06105931?
This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 15 participants. The study started on 2023-12-13. Estimated completion is 2028-06.
What conditions does trial NCT06105931 study?
This clinical trial studies the following conditions: Obesity, Type 1 Diabetes.
What interventions are being tested in trial NCT06105931?
The interventions under investigation include: Hyperinsulinemic-euglycemic clamp (BIOLOGICAL), High Fat Mixed Meal Tolerance Test (OTHER).
Who is sponsoring clinical trial NCT06105931?
This trial is sponsored by Yale University, which has 1,492 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06105931 being conducted?
This trial has 1 study location across Connecticut. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Obesity
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT06105931's enrollment target sits among peer trials
15 999th of 1053 higher than 46 of 1,053 other Obesity trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Obesity trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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