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NCT05784805 · ClinicalTrials.gov registry record · NA
Acute Effects of Focused Ultrasound Modulation on EEG Behavior in Status Epilepticus Patients
A NA study of Seizures, sponsored by Yale University.
- Recruiting
- Registry status
- NA
- Development phase
- 10
- Enrollment target
- 1
- Study location
NCT05784805: Recruiting NA study of Seizures, sponsored by Yale University.
NCT05784805 is a NA study of Seizures that is actively recruiting participants, run by Yale University. The registered enrollment target is 10 participants, below the 934-participant average among 39 other Seizures trials with a reported enrollment target (99% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05784805, a NA study of Seizures, is actively recruiting participants, sponsored by Yale University.
- RECRUITING
- Registry status
- NA
- Development phase
- 10 participants
- Enrollment target
- 1
- Study location
Study Summary
In this study, the investigators propose Pulsed Low-Intensity Focused Ultrasound (PLIFU) stimulation of brain regions that modulate (thalamus) or generate focal motor seizures (primary motor cortex), with the goal of ameliorating seizure activity in subjects in non-convulsive or focal motor status epilepticus. The course of treatment will consist of an initial 10 minute PLIFU treatment session with an option for a 2nd session if necessary. The primary objective of this study is to determine whether PLIFU reduces or suppresses epileptic activity in patients with Non-Convulsive Status Epilepticus (NCSE)/Focal Motor Status Epilepticus (FMSE) that have not responded to standard of care.
Primary Outcome
To determine the effect of PLIFU (duration of 10 minutes) on epileptic activity in participants with NCSE/FMSE that have not responded to standard of care using continuous surface EEG. A reduction or suppression of epileptic activity indicates a positive outcome.
Conditions Studied
Interventions
- DEVICE PLIFU
Study Locations (1)
Connecticut
- Yale New Haven Hospital - New Haven
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 10 participants |
| Start Date | 2023-06-24 |
| Est. Completion | 2026-02 |
| Phase | NA |
What NCT05784805 shows while recruiting
NCT05784805 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 10 participants, a relatively small participant target, below the 934-participant average among 39 other Seizures trials with a reported enrollment target (99% lower).
The record links to 1 condition, with Seizures appearing as the primary indexed condition, and to 1 intervention - of which PLIFU is the first listed.
NCT05784805 reports a single indexed study location in Connecticut.
Frequently Asked Questions
What is clinical trial NCT05784805 about?
NCT05784805 is a clinical study titled "Acute Effects of Focused Ultrasound Modulation on EEG Behavior in Status Epilepticus Patients". In this study, the investigators propose Pulsed Low-Intensity Focused Ultrasound (PLIFU) stimulation of brain regions that modulate (thalamus) or generate focal motor seizures (primary motor cortex), with the goal of ameliorating seizure activity in subjects in non-convulsive or focal motor status e...
What is the current status of trial NCT05784805?
This trial is currently recruiting. It is a NA study. The enrollment target is 10 participants. The study started on 2023-06-24. Estimated completion is 2026-02.
What conditions does trial NCT05784805 study?
This clinical trial studies the following conditions: Seizures.
What interventions are being tested in trial NCT05784805?
The interventions under investigation include: PLIFU (DEVICE).
Who is sponsoring clinical trial NCT05784805?
This trial is sponsored by Yale University, which has 1,492 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05784805 being conducted?
This trial has 1 study location across Connecticut. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Seizures
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT05784805's enrollment target sits among peer trials
10 38th of 39 higher than 2 of 39 other Seizures trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Seizures trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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