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Neural Substrates of Approach-Avoidance Conflict
NCT02119624 · View on ClinicalTrials.gov ↗
Study Summary
Background: \- People who are dependent on alcohol drink even when they know something bad might happen. Researchers want to learn more about why they do this. Objectives: \- To study brain response when a person plays a game in different threat conditions. Eligibility: * Healthy right-handed adult heavy drinkers age 21 60 * Healthy right-handed adult light drinkers age 21 60 Design: * Participants will be screened with medical history, physical exam, and blood and urine tests. They will have an EKG and psychiatric interview. * Participants will have one or two clinic visits. * Participants will be asked about their alcohol drinking. * They will choose a snack and alcoholic beverage that they must drink in 5 minutes. After their breath alcohol content (BrAC) is zero, they will play a game in the MRI scanner. * The scanner is a metal cylinder that takes pictures of the brain. Participants lie on a table that slides in and out of the cylinder. They will be in it for about 90 minutes, lying still for up to 20 minutes. * During the MRI, participants will play a simple computer game to earn food or drink points under different threats of electric shock. Points can be exchanged for food or alcohol after the game. Sometimes, participants will receive a mild electric shock through a metal disk on the wrist. Electric shocks will only happen if the participant tries to earn a reward point. * After the MRI, participants use their points for another drink and snack. They will stay at the clinic until their BrAC is low, usually within 3 hours. Participants cannot drive themselves home. * Participants will have a follow-up phone call the next day.
Conditions Studied
Study Locations (1)
Maryland
- National Institutes of Health Clinical Center, 9000 Rockville Pike — Bethesda
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 62 participants |
| Start Date | 2014-07-23 |
| Est. Completion | 2020-09-01 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT02119624
The ClinicalTrials.gov registry entry for NCT02119624 describes a study currently listed as completed. It is categorized as an unspecified phase, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 62 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is National Institute on Alcohol Abuse and Alcoholism (NIAAA), which has 118 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 3 conditions, with Alcoholism appearing as the primary indexed condition, and to 0 interventions. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT02119624 reports 1 study location spanning 1 distinct geographic area — top geographies include Maryland. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT02119624 about?
NCT02119624 is a clinical study titled "Neural Substrates of Approach-Avoidance Conflict". Background: \- People who are dependent on alcohol drink even when they know something bad might happen. Researchers want to learn more about why they do this. Objectives: \- To study brain response when a person plays a game in different threat conditions. Eligibility: * Healthy right-handed a...
What is the current status of trial NCT02119624?
This trial is currently completed. The enrollment target is 62 participants. The study started on 2014-07-23. Estimated completion is 2020-09-01.
What conditions does trial NCT02119624 study?
This clinical trial studies the following conditions: Alcoholism, fMRI, Rewarding Mediating System. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
Who is sponsoring clinical trial NCT02119624?
This trial is sponsored by National Institute on Alcohol Abuse and Alcoholism (NIAAA), which has 118 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT02119624 being conducted?
This trial has 1 study location across Maryland. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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