National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)

Open enrollment with an early-phase pipeline tilt

According to ClinicalTrials.gov-derived indexes, National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) sits in the top decile of US sponsors by registered trial count (#253 of 15,742 sponsors by registered trial count).

93 total trials 12 currently recruiting 71 completed early-phase tilt top decile by trial count

National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS): 93 sponsored US clinical trials, 12 recruiting.

National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) sponsors 93 registered US clinical trials on ClinicalTrials.gov, 12 of them currently recruiting, and 71 completed. 4 of these trials are in Phase 3-4 (later-stage) and 45 in Phase 1-2 (earlier-stage). The most-studied condition in this pipeline is Arthritis, with 4 trials.

Top-decile sponsor footprint

National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) ranks in the top decile of sponsors by registered trial count (#253 of 15,742 sponsors by registered trial count). Volume at this scale usually reflects a long institutional pipeline, read phase tilt and therapeutic areas below before treating it as current-year activity.

Trial completion reliability score

D 62/100

71 of 80 decided trials (Completed vs. Terminated on ClinicalTrials.gov) reached their planned completion (88.8%), vs. national p10 68.4% / p90 100% among 1,234 sponsors with at least 10 decided trials. Still-open trials (Recruiting, Active-not-recruiting, Not-yet-recruiting) are excluded since they have not reached an outcome yet.

Open and recent trials

93 total, page 1 of 2

RECRUITING Phase 2

The Role of Anifrolumab in Improving Markers of Vascular Risk in Patients With Systemic Lupus Erythematosus (SLE) - IFN-CVD

NCT05440422

RECRUITING

Natural History of Inflammatory Muscle Diseases

NCT05738824

RECRUITING

Gonadotropin-releasing Hormone Agonist (GnRHa) in Ovarian Preservation in SLE Subjects Receiving Cyclophosphamide as Determined by Questionnaires

NCT05567198

RECRUITING

Natural History, Genetics, and Pathophysiology of Systemic Juvenile Idiopathic Arthritis, Adult-Onset Still's Disease, and Related Conditions

NCT03510442

RECRUITING

Natural History, Pathogenesis and Outcome of Melorheostosis A Rare Osteosclerotic Disease

NCT02504879

RECRUITING

Studies of Dermatologic Diseases Biospecimen Acquisition Protocol

NCT02471352

RECRUITING

Studies of the Natural History, Pathogenesis, and Outcome of Idiopathic Systemic Vasculitis

NCT02257866

RECRUITING Phase 2

Effects of Treatments on Atopic Dermatitis

NCT01631617

RECRUITING

Natural History and Development of Spondyloarthritis

NCT01422694

RECRUITING

Studies of the Natural History, Pathogenesis, and Outcome of Autoinflammatory Diseases Including Juvenile Dermatomyositis

NCT00059748

RECRUITING

Studies of the Natural History of Rheumatic Diseases

NCT00024479

RECRUITING

Study of Systemic Lupus Erythematosus

NCT00001372

ACTIVE NOT RECRUITING

Frequency and Complications of Major Orthopedic Procedures in Medicare Beneficiaries

NCT02281747

COMPLETED

Natural History and Pathogenesis of Alopecia in Children and Adults

NCT05502796

COMPLETED

Natural History of Coronavirus Disease (COVID-19) in Systemic Autoimmune Diseases

NCT04690816

COMPLETED Early Phase 1

Genomic Effects of Glucocorticoids in Patients With Systemic Lupus Erythematosus

NCT04233164

TERMINATED Phase 2

Topical Ruxolitinib for Cutaneous Chronic Graft Versus Host Disease (cGVHD)

NCT03395340

COMPLETED Phase 1

Safety of Tofacitinib, an Oral Janus Kinase Inhibitor, in Systemic Lupus Erythematosus

NCT02535689

COMPLETED Phase 1

Role of PPAR-y Agonists in Immunomodulation and Vascular Prevention in SLE (PPAR-SLE)

NCT02338999

COMPLETED Phase 1

Omalizumab for Lupus

NCT01716312

COMPLETED Phase 2

Anakinra for Inflammatory Pustular Skin Diseases

NCT01794117

COMPLETED Phase 2

Rilonacept for Deficiency of the Interleukin-1 Receptor Antagonist (DIRA)

NCT01801449

COMPLETED Phase 1

Anakinra for Behcet s Disease

NCT01441076

TERMINATED

Genetic Basis of Primary Immunodeficiencies

NCT00001788

COMPLETED

Bisphosphonate Users Radiographic Characteristics of the Hip (BURCH) Study

NCT01360099

COMPLETED Phase 2

Abatacept for Treating Adults With Giant Cell Arteritis and Takayasu's Arteritis

NCT00556439

COMPLETED

Insulin Resistance and Atherosclerosis in Women With Lupus

NCT00544102

COMPLETED Phase 1

A Pilot of Pediatric/Adult Study of Gene Expression Profiling and Clinical Characterization of Phototoxicity

NCT00353158

COMPLETED

Progression of Spinal Fusion in Ankylosing Spondylitis

NCT00085995

COMPLETED Phase 2

Interleukin-1 Trap to Treat Autoinflammatory Diseases

NCT00094900

COMPLETED

Osteoarthritis Initiative (OAI): A Knee Health Study

NCT00080171

COMPLETED Phase 1

Electromagnetic Treatment For Bone Loss After Forearm Fracture

NCT00067834

COMPLETED NA

Protective Brace to Prevent Hand and Arm Injuries

NCT00074893

TERMINATED Phase 1

Anakinra to Treat Patients With Neonatal Onset Multisystem Inflammatory Disease

NCT00069329

COMPLETED

Genetic Determinants of Ankylosing Spondylitis Severity - Longitudinal Study

NCT00056719

COMPLETED Phase 2

Treating Rheumatoid Arthritis With Tripterygium Wilfordi Hook F or Sulfasalazine

NCT00062465

COMPLETED

Genetic Determinants of Ankylosing Spondylitis Severity

NCT00056849

COMPLETED

Clinically Important Changes in Rheumatoid Arthritis

NCT00056602

COMPLETED Phase 2

Gabapentin in Fibromyalgia Trial (GIFT)

NCT00057278

TERMINATED Phase 2

Image Guided System for Orthopaedic Surgery

NCT00022802

COMPLETED Phase 1

Monoclonal Antibody Treatment for Systemic Lupus Erythematosus

NCT00046774

COMPLETED

Role of Antibodies in Cognitive Dysfunction in Patients With Systemic Lupus Erythematosus

NCT00042523

COMPLETED Phase 3

Nitroglycerin Ointment for Preventing Bone Loss in Postmenopausal Women

NCT00043719

TERMINATED Phase 1

Safety and Value of Self Bone Marrow Transplants Following Chemotherapy in Scleroderma Patients

NCT00040651

COMPLETED Phase 1

Management of Compartment Syndrome With Ultrafiltration

NCT00022815

COMPLETED Phase 2

Infliximab (Remicade ) to Treat Dermatomyositis and Polymyositis

NCT00033891

COMPLETED Phase 2

The Role of Cytokines on Growth Hormone Suppression in Premenopausal Women With Rheumatoid Arthritis and the Effect of Treatment With Etanercept

NCT00034060

TERMINATED

Blood Component Collection From Patients With Rheumatic or Kidney Disease and Healthy Volunteers

NCT00031174

COMPLETED

Positron Emission Tomography (PET) to Locate Areas of White Blood Cell Activity

NCT00029926

TERMINATED Phase 2

Infliximab to Treat Children With Juvenile Rheumatoid Arthritis

NCT00029042

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What is open in the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) pipeline

12 recruiting of 93 indexed (13% open); 71 completed (76%).

Phase mix: 4 late (III/IV) vs 45 early (I/II) (early-phase heavy).

Top condition: Arthritis (4 trials), 9 others listed.

How open-pipeline share is computed

Recruiting share is recruiting_count divided by trial_count for this sponsor in the public registry export. Status can change between pulls; treat the figure as a research-attention snapshot, not product availability.

National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS): open-pipeline peers nationwide

Peers matched on 93 registered trials and 13% open enrollment, not the therapeutic-area sidebar.

National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) sits at or above the median trial volume and at or above the median recruiting share among these 9 nationwide peers -- the two do not always move together. Source: ClinicalTrials.gov (2026-08-08 snapshot). 2×2 strategic matrix plotting 9 entities by Total trials (X) and Recruiting share (Y), with a crosshair dividing the plot into four quadrants. Higher volume & more openFocused & more openHigher volume, mostly closedSmaller & mostly closed 05001,0001,500 0%5%10%15%20%25% Total trials Recruiting share National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)National Institute on Alcohol Abuse and Alcoholism (NIAAA)Roxane LaboratoriesColorado State UniversityEndeavor HealthMcMaster UniversityTemple UniversityUniversity of PittsburghIntermountain Health Care
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) sits at or above the median trial volume and at or above the median recruiting share among these 9 nationwide peers -- the two do not always move together. Source: ClinicalTrials.gov (2026-08-08 snapshot).

National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) sits at or above the median trial volume and at or above the median recruiting share among these 9 nationwide peers -- the two do not always move together.

Sponsors near 93 trials (± recruiting share)

Sponsors near 13% open enrollment (± trial volume)

What to do with this National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) page

93 registered trials is a research-attention snapshot, not an endorsement of National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) or any single study.

  • 12 of National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)'s trials are currently recruiting, check each one's own eligibility criteria before contacting a site. Browse recruiting trials
  • Arthritis is the condition National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) studies most, compare against other sponsors active in the same condition before evaluating a specific study. See Arthritis trials
  • Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide

Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.

National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) pipeline card: 93 registered trials from official public datasets.Report a data error.