National Institute of Neurological Disorders and Stroke (NINDS)

Open enrollment with an early-phase pipeline tilt

According to ClinicalTrials.gov-derived indexes, National Institute of Neurological Disorders and Stroke (NINDS) sits in the top decile of US sponsors by registered trial count (#61 of 15,742 sponsors by registered trial count).

567 total trials 48 currently recruiting 467 completed early-phase tilt top decile by trial count

National Institute of Neurological Disorders and Stroke (NINDS): 567 sponsored US clinical trials, 48 recruiting.

National Institute of Neurological Disorders and Stroke (NINDS) sponsors 567 registered US clinical trials on ClinicalTrials.gov, 48 of them currently recruiting, and 467 completed. 16 of these trials are in Phase 3-4 (later-stage) and 158 in Phase 1-2 (earlier-stage). The most-studied condition in this pipeline is Healthy, with 23 trials.

Top-decile sponsor footprint

National Institute of Neurological Disorders and Stroke (NINDS) ranks in the top decile of sponsors by registered trial count (#61 of 15,742 sponsors by registered trial count). Volume at this scale usually reflects a long institutional pipeline, read phase tilt and therapeutic areas below before treating it as current-year activity.

Trial completion reliability score

C 70/100

467 of 508 decided trials (Completed vs. Terminated on ClinicalTrials.gov) reached their planned completion (91.9%), vs. national p10 68.4% / p90 100% among 1,234 sponsors with at least 10 decided trials. Still-open trials (Recruiting, Active-not-recruiting, Not-yet-recruiting) are excluded since they have not reached an outcome yet.

Open and recent trials

567 total, page 11 of 12

COMPLETED Phase 2

Recombinant Human Interferon Beta-1a (Avonex) for the Treatment of Patients With HTLV-1-Associated Myelopathy (HAM)

NCT00001785

COMPLETED Phase 2

Mexiletine for the Treatment of Focal Dystonia

NCT00001784

COMPLETED Phase 2

Motor Recovery in Recent Stroke Patients Treated With Amphetamine and Physical Therapy

NCT00001783

COMPLETED

Areas of Brain Responsible for Understanding American Sign Language

NCT00001782

COMPLETED

Magnetic Stimulation of the Human Nervous System

NCT00001780

COMPLETED Phase 2

Safety, Tolerability, and Effectiveness of CGP77116 in Patients With Multiple Sclerosis (MS)

NCT00001781

COMPLETED Phase 3

Timing of Levodopa Treatment in Parkinson's Disease

NCT00004733

COMPLETED Phase 1

Sertraline for the Treatment of Patients With Frontal Lobe Dementia (FLD)

NCT00001777

COMPLETED

Vasodilation in Patients With Fabry's Disease

NCT00001774

COMPLETED

Effects of Brain Stimulation on Learning and Reasoning

NCT00001776

COMPLETED

The Classification and Cause of Leukodystrophies of Unknown Cause

NCT00001671

COMPLETED

Language Localization Using Repetitive Transcranial Magnetic Stimulation (rTMS) in Patients With Epilepsy

NCT00001672

COMPLETED NA

Ketogenic Diet for Child Epilepsy and Seizure Control

NCT00004729

COMPLETED Phase 2

A 48-Week (24-Week Baseline Followed by a 24-Week Treatment) Phase II Pilot Study of the Tolerability and Effect/Efficacy of Subcutaneously Administered Insulin-Like Growth Factor-1 (rhIGF) (CEP-151) in Multiple Sclerosis (MS) Patients

NCT00001669

COMPLETED

Endolymphatic Sac Tumors in a Population of Patients With Von Hippel-Lindau Disease:The Natural History and Pathobiology, and a Prospective Non-Randomized Clinical Trial of Hearing Preservation Surgery in Patients With Early Stage Endolymphatic Sac Tumors

NCT00001668

COMPLETED

Transcranial Magnetic Stimulation for the Treatment of Poorly Controlled Partial Epilepsy

NCT00001666

COMPLETED

Genotype/Phenotype Correlation of Movement Disorders and Other Neurological Diseases

NCT00001667

COMPLETED Phase 1

Treatment of Cortical Myoclonus With Repetitive Transcranial Magnetic Stimulation

NCT00001663

COMPLETED

Transcranial Magnetic Stimulation for the Treatment of Parkinson's Disease

NCT00001665

COMPLETED

Sleep Disorders of Patients With Diseases of the Nervous System

NCT00001664

COMPLETED

Mechanisms of Human Plasticity in the Human System

NCT00001661

COMPLETED Phase 2

Treatment of Alzheimer's Disease With CX516 (Ampalex)

NCT00001662

COMPLETED Phase 3

Vitamin Therapy for Prevention of Stroke

NCT00004734

COMPLETED Phase 1

Infrared Camera for Brain Mapping During Surgery

NCT00001554

COMPLETED

Characteristics of Idiopathic Familial Speech Disorders

NCT00001551

COMPLETED

Characteristics of Idiopathic Familial Voice Disorders

NCT00001552

COMPLETED

Motor Changes Associated With Recovery From Stroke After Therapy

NCT00001553

COMPLETED Phase 1

Intravenous Immunoglobulin (IVIg) for the Treatment of Stiff-Man Syndrome (SMS)

NCT00001550

COMPLETED

Diagnosis and Natural History Study of Patients With Neurological Conditions

NCT00001549

COMPLETED

Analysis of the Nervous System in Patients With Fabry's Disease

NCT00001491

COMPLETED

Effect of Vigabatrin on Brain Blood Flow and Glucose Metabolism

NCT00001489

COMPLETED

PET Scan of Brain Metabolism in Relation to Age and Disease

NCT00001972

COMPLETED

PET Scan in Patients With Neurocardiologic Disorders

NCT00001418

COMPLETED

Direct Injection of Alcohol for the Treatment of Spinal Tumors

NCT00001417

COMPLETED Phase 2

Bone Response to Enzyme Replacement in Gaucher's Disease

NCT00001416

COMPLETED Phase 1

Potential Risk Factors for Stroke

NCT00001368

COMPLETED

Diagnosis and History Study of Patients With Different Neurological Conditions

NCT00001367

COMPLETED

Mapping the Areas of the Brain Associated With Language in Children With Epilepsy

NCT00001366

COMPLETED Phase 2

Dextromethorphan for the Treatment of Parkinson's Disease and Similar Conditions of the Nervous System

NCT00001365

COMPLETED

Evaluation and Treatment of Patients Spinal Blood Vessel Abnormalities

NCT00001364

COMPLETED

PET Scan to Map the Areas of the Brain Involved in Planning

NCT00001363

COMPLETED

Magnetic Resonance Imaging for the Study of Patients With Neurological Disorders

NCT00001362

COMPLETED

Magnetic Resonance Imaging Studies of Motor and Thought Processes

NCT00001361

COMPLETED

Study of Norepinephrine Levels and Sympathetic Nervous System Activity

NCT00001329

COMPLETED Phase 1

Gene Therapy for the Treatment of Brain Tumors

NCT00001328

COMPLETED

Establishing the Physiology of Syringomyelia

NCT00001327

COMPLETED

Metabolic Abnormalities in Children With Epilepsy

NCT00001325

COMPLETED

PET Scan to Study Brain Control of Human Movement

NCT00001324

COMPLETED

Effects of Enzyme Replacement in Gaucher's Disease

NCT00001289

COMPLETED

Brain Blood Flow Studies of Language and Memory

NCT00001288

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Phase Distribution

PhaseTrial count
Phase 1 80
Phase 2 78
Phase 3 11
Phase 4 5

What is open in the National Institute of Neurological Disorders and Stroke (NINDS) pipeline

48 recruiting of 567 indexed (8% open); 467 completed (82%).

Phase mix: 16 late (III/IV) vs 158 early (I/II) (early-phase heavy).

Top condition: Healthy (23 trials), 9 others listed.

How open-pipeline share is computed

Recruiting share is recruiting_count divided by trial_count for this sponsor in the public registry export. Status can change between pulls; treat the figure as a research-attention snapshot, not product availability.

National Institute of Neurological Disorders and Stroke (NINDS): open-pipeline peers nationwide

Peers matched on 567 registered trials and 8% open enrollment, not the therapeutic-area sidebar.

National Institute of Neurological Disorders and Stroke (NINDS) sits at or above the median trial volume and below the median recruiting share among these 9 nationwide peers -- the two do not always move together. Source: ClinicalTrials.gov (2026-08-08 snapshot). 2×2 strategic matrix plotting 9 entities by Total trials (X) and Recruiting share (Y), with a crosshair dividing the plot into four quadrants. Higher volume & more openFocused & more openHigher volume, mostly closedSmaller & mostly closed 0200400600 5%10%15%20%25% Total trials Recruiting share National Institute of Neurological Disorders and Stroke (NINDS)Children's Hospital Medical Center, CincinnatiUniversity of Maryland, BaltimoreAmgenMerck Sharp & DohmeNational Jewish HealthACADIA PharmaceuticalsTexas Tech University Health Sciences Center, El PasoBoehringer Ingelheim
National Institute of Neurological Disorders and Stroke (NINDS) sits at or above the median trial volume and below the median recruiting share among these 9 nationwide peers -- the two do not always move together. Source: ClinicalTrials.gov (2026-08-08 snapshot).

National Institute of Neurological Disorders and Stroke (NINDS) sits at or above the median trial volume and below the median recruiting share among these 9 nationwide peers -- the two do not always move together.

Sponsors near 567 trials (± recruiting share)

Sponsors near 8% open enrollment (± trial volume)

What to do with this National Institute of Neurological Disorders and Stroke (NINDS) page

567 registered trials is a research-attention snapshot, not an endorsement of National Institute of Neurological Disorders and Stroke (NINDS) or any single study.

  • 48 of National Institute of Neurological Disorders and Stroke (NINDS)'s trials are currently recruiting, check each one's own eligibility criteria before contacting a site. Browse recruiting trials
  • Healthy is the condition National Institute of Neurological Disorders and Stroke (NINDS) studies most, compare against other sponsors active in the same condition before evaluating a specific study. See Healthy trials
  • Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide

Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. National Institute of Neurological Disorders and Stroke (NINDS) pipeline card: 567 registered trials from official public datasets. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.