National Institute of Neurological Disorders and Stroke (NINDS)

Open enrollment with an early-phase pipeline tilt

According to ClinicalTrials.gov-derived indexes, National Institute of Neurological Disorders and Stroke (NINDS) sits in the top decile of US sponsors by registered trial count (#61 of 15,742 sponsors by registered trial count).

567 total trials 48 currently recruiting 467 completed early-phase tilt top decile by trial count

National Institute of Neurological Disorders and Stroke (NINDS): 567 sponsored US clinical trials, 48 recruiting.

National Institute of Neurological Disorders and Stroke (NINDS) sponsors 567 registered US clinical trials on ClinicalTrials.gov, 48 of them currently recruiting, and 467 completed. 16 of these trials are in Phase 3-4 (later-stage) and 158 in Phase 1-2 (earlier-stage). The most-studied condition in this pipeline is Healthy, with 23 trials.

Top-decile sponsor footprint

National Institute of Neurological Disorders and Stroke (NINDS) ranks in the top decile of sponsors by registered trial count (#61 of 15,742 sponsors by registered trial count). Volume at this scale usually reflects a long institutional pipeline, read phase tilt and therapeutic areas below before treating it as current-year activity.

Trial completion reliability score

C 70/100

467 of 508 decided trials (Completed vs. Terminated on ClinicalTrials.gov) reached their planned completion (91.9%), vs. national p10 68.4% / p90 100% among 1,234 sponsors with at least 10 decided trials. Still-open trials (Recruiting, Active-not-recruiting, Not-yet-recruiting) are excluded since they have not reached an outcome yet.

Open and recent trials

567 total, page 10 of 12

COMPLETED

Physiologic Studies of Spasticity

NCT00014976

COMPLETED Phase 2

Amlodipine Plus Botulinum Toxin for Focal Dystonia

NCT00015457

COMPLETED

Effects of Flumazenil on Brain Excitability

NCT00015678

COMPLETED

Magnetic Resonance Imaging to Investigate Silent Strokes During Neck and Skull Angioplasty

NCT00015717

COMPLETED Phase 2

Riluzole to Treat Parkinson's Disease

NCT00013624

TERMINATED Phase 2

E-Selectin Nasal Spray to Prevent Stroke Recurrence

NCT00012454

COMPLETED

Study and Surgical Treatment of Syringomyelia

NCT00011245

COMPLETED Phase 2

Rolipram to Treat Multiple Sclerosis

NCT00011375

COMPLETED Phase 2

EMD 128130 for the Treatment of Parkinson's Disease

NCT00009048

COMPLETED

Ketogenic Diet in Lafora Disease

NCT00007124

COMPLETED

Gluten-Free Diet in Patients With Gluten Sensitivity and Cerebellar Ataxia

NCT00006492

COMPLETED

Study of Brain Changes Shaped by Experience

NCT00006424

COMPLETED Phase 2

KW-6002 to Treat Parkinson's Disease

NCT00006337

COMPLETED

Hand Exercise and Upper Arm Anesthesia to Improvements Hand Function in Chronic Stroke Patients

NCT00006414

COMPLETED

Sensory Training to Treat Focal Dystonia

NCT00006336

COMPLETED Phase 2

Effects of Monoamine Reuptake Inhibitor NS2330 in Parkinson's Disease

NCT00006077

COMPLETED

Effect of Levetiracetam on Brain Excitability

NCT00006191

TERMINATED Phase 1

Brain Infusion of Muscimol to Treat Epilepsy

NCT00005925

COMPLETED Phase 2

Continuously Infused Recombinant-Methionyl Human Glial Cell Line-Derived Neurotrophic Factor (GDNF) to Treat Progressive Supranuclear Palsy

NCT00005903

COMPLETED

PET Scans in Normal Volunteers and Patients With Fabry Disease

NCT00005111

COMPLETED

Study of Brain Activity During Speech Production and Speech Perception

NCT00004991

COMPLETED NA

Electromyography to Diagnose Neuromuscular Disorders

NCT00004553

COMPLETED Phase 1

Gentamicin Treatment of Muscular Dystrophy

NCT00005574

COMPLETED Phase 3

Hypothermia During Intracranial Aneurysm Surgery Trial

NCT00029133

COMPLETED Phase 2

Study of LY300164 for the Treatment of Parkinson's Disease

NCT00004576

COMPLETED

Positron Emission Tomography (PET) to Study Brain Signaling

NCT00044200

COMPLETED Phase 1

1-Octanol to Treat Essential Tremor

NCT00001986

COMPLETED Phase 2

Brain Imaging and Retreatment Study of Persistent Lyme Disease

NCT00037479

COMPLETED

Blood Sampling for Neurochemical and Genetic Testing

NCT00001147

COMPLETED

Detecting Malignant Brain Tumor Cells in the Bloodstream During Surgery to Remove the Tumor

NCT00001148

COMPLETED Phase 2

Oxandrolone Compared With a Placebo on Growth Rate in Girls With Growth Hormone-Treated Turner's Syndrome

NCT00004275

COMPLETED

Electrical Muscle Stimulation to Aid Swallowing in Dysphagia

NCT00001936

COMPLETED Phase 2

Zenapax to Treat Multiple Sclerosis

NCT00001934

COMPLETED

Study of Phenotype and Genotype Correlations in Patients With Contiguous Gene Deletion Syndromes

NCT00004351

COMPLETED Phase 2

Nefiracetam in the Treatment of Alzheimer's Disease

NCT00001933

COMPLETED

Serotonin Receptors in Seizure Disorders

NCT00001932

COMPLETED Phase 2

Treatment of Parkinson's Disease With a Transdermal Skin Patch

NCT00001931

COMPLETED

The Connection Between Areas in the Brain of Blind Patients

NCT00001926

COMPLETED Phase 2

Treatment of Huntington's Chorea With Amantadine

NCT00001930

COMPLETED Phase 2

Treatment of Parkinson's Disease With Eliprodil

NCT00001929

COMPLETED

Intravenous Levodopa for the Diagnosis of Parkinson's Disease

NCT00001928

COMPLETED

Study of Abnormal Blood Clotting in Children With Stroke

NCT00001927

COMPLETED

Study of Attention Deficit/Hyperactivity Disorder Using Transcranial Magnetic Stimulation

NCT00001915

COMPLETED Phase 3

Reduced Manipulation of the Aorta and Neurobehavioral Outcome Trial

NCT00059319

COMPLETED Phase 3

Theory-Based Interventions for Smoking and Obesity (Challenge) Trial

NCT00040287

COMPLETED Phase 2

Effect of Alcohol on Tremors

NCT00001925

COMPLETED Phase 1

Transcranial Magnetic Stimulation for the Treatment of Phantom Pain

NCT00001923

COMPLETED

Sensory Function in Idiopathic Voice Disorders

NCT00001922

COMPLETED Phase 2

Efficacy of a Family Telephone Intervention for Stroke

NCT00031265

COMPLETED Phase 2

Parkinson's Disease Treatment With Coenzyme Q10

NCT00004731

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Phase Distribution

PhaseTrial count
Phase 1 80
Phase 2 78
Phase 3 11
Phase 4 5

What is open in the National Institute of Neurological Disorders and Stroke (NINDS) pipeline

48 recruiting of 567 indexed (8% open); 467 completed (82%).

Phase mix: 16 late (III/IV) vs 158 early (I/II) (early-phase heavy).

Top condition: Healthy (23 trials), 9 others listed.

How open-pipeline share is computed

Recruiting share is recruiting_count divided by trial_count for this sponsor in the public registry export. Status can change between pulls; treat the figure as a research-attention snapshot, not product availability.

National Institute of Neurological Disorders and Stroke (NINDS): open-pipeline peers nationwide

Peers matched on 567 registered trials and 8% open enrollment, not the therapeutic-area sidebar.

National Institute of Neurological Disorders and Stroke (NINDS) sits at or above the median trial volume and below the median recruiting share among these 9 nationwide peers -- the two do not always move together. Source: ClinicalTrials.gov (2026-08-08 snapshot). 2×2 strategic matrix plotting 9 entities by Total trials (X) and Recruiting share (Y), with a crosshair dividing the plot into four quadrants. Higher volume & more openFocused & more openHigher volume, mostly closedSmaller & mostly closed 0200400600 5%10%15%20%25% Total trials Recruiting share National Institute of Neurological Disorders and Stroke (NINDS)Children's Hospital Medical Center, CincinnatiUniversity of Maryland, BaltimoreAmgenMerck Sharp & DohmeNational Jewish HealthACADIA PharmaceuticalsTexas Tech University Health Sciences Center, El PasoBoehringer Ingelheim
National Institute of Neurological Disorders and Stroke (NINDS) sits at or above the median trial volume and below the median recruiting share among these 9 nationwide peers -- the two do not always move together. Source: ClinicalTrials.gov (2026-08-08 snapshot).

National Institute of Neurological Disorders and Stroke (NINDS) sits at or above the median trial volume and below the median recruiting share among these 9 nationwide peers -- the two do not always move together.

Sponsors near 567 trials (± recruiting share)

Sponsors near 8% open enrollment (± trial volume)

What to do with this National Institute of Neurological Disorders and Stroke (NINDS) page

567 registered trials is a research-attention snapshot, not an endorsement of National Institute of Neurological Disorders and Stroke (NINDS) or any single study.

  • 48 of National Institute of Neurological Disorders and Stroke (NINDS)'s trials are currently recruiting, check each one's own eligibility criteria before contacting a site. Browse recruiting trials
  • Healthy is the condition National Institute of Neurological Disorders and Stroke (NINDS) studies most, compare against other sponsors active in the same condition before evaluating a specific study. See Healthy trials
  • Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide

Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. National Institute of Neurological Disorders and Stroke (NINDS) pipeline card: 567 registered trials from official public datasets. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.