National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Open enrollment with an early-phase pipeline tilt

According to ClinicalTrials.gov-derived indexes, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) sits in the top decile of US sponsors by registered trial count (#74 of 15,742 sponsors by registered trial count).

490 total trials 50 currently recruiting 398 completed early-phase tilt top decile by trial count

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK): 490 sponsored US clinical trials, 50 recruiting.

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) sponsors 490 registered US clinical trials on ClinicalTrials.gov, 50 of them currently recruiting, and 398 completed. 69 of these trials are in Phase 3-4 (later-stage) and 178 in Phase 1-2 (earlier-stage). The most-studied condition in this pipeline is Obesity, with 25 trials.

Top-decile sponsor footprint

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) ranks in the top decile of sponsors by registered trial count (#74 of 15,742 sponsors by registered trial count). Volume at this scale usually reflects a long institutional pipeline, read phase tilt and therapeutic areas below before treating it as current-year activity.

Trial completion reliability score

C 74/100

398 of 424 decided trials (Completed vs. Terminated on ClinicalTrials.gov) reached their planned completion (93.9%), vs. national p10 68.4% / p90 100% among 1,234 sponsors with at least 10 decided trials. Still-open trials (Recruiting, Active-not-recruiting, Not-yet-recruiting) are excluded since they have not reached an outcome yet.

Open and recent trials

490 total, page 8 of 10

COMPLETED Phase 2

Leptin to Treat Lipodystrophy

NCT00025883

COMPLETED NA

Motivations for Weight Loss

NCT00011115

COMPLETED

Genetic Analysis of Familial Keloids

NCT00008502

COMPLETED Phase 2

Lamivudine and Adefovir to Treat Chronic Hepatitis B

NCT00023309

COMPLETED Phase 2

Pegylated Interferon to Treat Chronic Hepatitis D

NCT00023322

COMPLETED Phase 3

Diabetes Therapy to Improve BMI and Lung Function in CF

NCT00072904

COMPLETED

Prevention of Recurrent Hepatitis B After Liver Transplantation

NCT00059267

COMPLETED Phase 2

Treatment of Nonalcoholic Steatohepatitis With Pioglitazone

NCT00013598

COMPLETED NA

Prevention of Weight Gain

NCT00011102

COMPLETED Phase 2

Kidney Transplant for HIV-Infected Patients in Renal Failure

NCT00009009

COMPLETED Phase 1

Permeability Factor in Focal Segmental Glomerulosclerosis

NCT00007475

COMPLETED Phase 2

Solitary Islet Transplantation for Type 1 Diabetes Mellitus Using Steroid Sparing Immunosuppression

NCT00006505

COMPLETED Phase 3

Gabapentin to Treat Itch in Patients With Liver Disease

NCT00058890

COMPLETED Phase 4

A Study to Determine How and Why HIV-Infected Subjects on Anti-viral Treatment Develop Lipodystrophy

NCT00006190

COMPLETED NA

Randomized Trial of Health Events Costs in Diabetic Blacks

NCT00022750

COMPLETED

Immune Response to Hepatitis C Virus

NCT00006301

COMPLETED Phase 2

Oxidative Stress and Vitamin E Requirements

NCT00067899

COMPLETED Phase 3

Vitamin K and Bone Turnover in Postmenopausal Women

NCT00062595

COMPLETED NA

The Use of the Internet to Facilitate Weight Loss and Maintenance.

NCT00008827

COMPLETED NA

Differential Metabolism of Dietary Fatty Acids

NCT00059254

COMPLETED Phase 2

Sirolimus and Thymoglobulin to Prevent Kidney Transplant Rejection

NCT00006178

COMPLETED Phase 2

Islet Cell Transplantation Alone in Patients With Type I Diabetes Mellitus: Steroid-free Immunosuppression

NCT00021788

TERMINATED

Search for New Methods to Detect Acute Renal Failure

NCT00026702

COMPLETED

Evaluation of New Test Method to Measure Kidney Function

NCT00026715

COMPLETED Phase 3

Long Term Interferon for Patients Who Did Not Clear Hepatitis C Virus With Standard Treatment

NCT00006164

COMPLETED NA

Laparoscopy to Remove Pancreatic Tumors (Insulinomas)

NCT00005910

COMPLETED Phase 2

5-Azacytidine and Phenylbutyrate to Treat Severe Thalassemia

NCT00005934

COMPLETED Phase 2

Leptin to Treat Lipodystrophy

NCT00005905

COMPLETED

Genetics of Hepatitis C Virus Infection

NCT00005657

COMPLETED NA

Altered Calcium and Vitamin D in PMDD or Severe PMS

NCT00005119

COMPLETED Phase 2

NEW DAY: Nutrition, Exercise, Weight Loss, Diabetes And You

NCT00007800

COMPLETED NA

Physical Activity in the Treatment of Obesity

NCT00615238

COMPLETED

Energy Homeostasis in Anorexia Nervosa

NCT00368667

COMPLETED Phase 2

Islet Cell Transplantation Alone and CD34+ Enriched Bone Marrow Cell Infusion in Patients With Diabetes Mellitus: Steroid-Free Regimen

NCT00021801

COMPLETED Phase 2

Once-A-Month Steroid Treatment for Patients With Focal Segmental Glomerulosclerosis

NCT00004990

COMPLETED Phase 1

A Phase I/II Trial of Recombinant-Methionyl Human Stem Cell Factor (SCF) in Adult Patients With Sickling Disorders

NCT00005783

COMPLETED Phase 2

A Study of the Safety and Efficacy of Tobramycin for Inhalation in Young Children With Cystic Fibrosis

NCT00006280

COMPLETED

Food Intake and Appetite in the Children of Mothers With Diabetes

NCT00339313

COMPLETED NA

Glomerular Injury of Preeclampsia

NCT00275158

COMPLETED NA

Evaluating "Health at Every Size"(HAES) as an Alternative Obesity Treatment Model

NCT00074633

COMPLETED Phase 3

Mobilization and Handling of Stem Cells for Transplant From Healthy Volunteers With Sickle Cell Trait

NCT00005782

COMPLETED

Genetic Influence on Susceptibility to Type 1 Diabetes Mellitus

NCT00001985

COMPLETED Phase 2

Hydroxyurea to Treat Beta-Thalassemia (Cooley's Anemia)

NCT00001958

COMPLETED Phase 2

Pirfenidone to Treat Kidney Disease (Focal Segmental Glomerulosclerosis)

NCT00001959

COMPLETED

The Food Intake Phenotype: Assessing Eating Behavior and Food Preferences as Risk Factors for Obesity

NCT00342732

COMPLETED Phase 2

Effectiveness of the Investigational Drug Campath-1H in Preventing Rejection of Transplanted Kidneys

NCT00001984

COMPLETED

The Family Investigation of Nephropathy and Diabetes Study

NCT00301249

COMPLETED NA

Education and Group Support for Diabetic Hispanics

NCT00004983

COMPLETED Phase 1

Stem Cell (Modified Bone Marrow) Transplantation in HIV-Infected Patients With Blood Cancer

NCT00005785

COMPLETED NA

Biofeedback for Dyssynergic Constipation

NCT00127257

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Phase Distribution

PhaseTrial count
Phase 1 42
Phase 2 136
Phase 3 55
Phase 4 14

What is open in the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) pipeline

50 recruiting of 490 indexed (10% open); 398 completed (81%).

Phase mix: 69 late (III/IV) vs 178 early (I/II) (early-phase heavy).

Top condition: Obesity (25 trials), 9 others listed.

How open-pipeline share is computed

Recruiting share is recruiting_count divided by trial_count for this sponsor in the public registry export. Status can change between pulls; treat the figure as a research-attention snapshot, not product availability.

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK): open-pipeline peers nationwide

Peers matched on 490 registered trials and 10% open enrollment, not the therapeutic-area sidebar.

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) sits at or above the median trial volume and below the median recruiting share among these 9 nationwide peers -- the two do not always move together. Source: ClinicalTrials.gov (2026-08-08 snapshot). 2×2 strategic matrix plotting 9 entities by Total trials (X) and Recruiting share (Y), with a crosshair dividing the plot into four quadrants. Higher volume & more openFocused & more openHigher volume, mostly closedSmaller & mostly closed 0200400600 8%10%12%14%16%18% Total trials Recruiting share National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)Beth Israel Deaconess Medical CenterFred Hutchinson Cancer CenterNational Heart, Lung, and Blood Institute (NHLBI)H. Lee Moffitt Cancer Center and Research InstituteMirati TherapeuticsJames J. Peters Veterans Affairs Medical CenterCalifornia Pacific Medical Center Research InstituteNational Institute of Environmental Health Sciences (NIEHS)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) sits at or above the median trial volume and below the median recruiting share among these 9 nationwide peers -- the two do not always move together. Source: ClinicalTrials.gov (2026-08-08 snapshot).

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) sits at or above the median trial volume and below the median recruiting share among these 9 nationwide peers -- the two do not always move together.

Sponsors near 490 trials (± recruiting share)

Sponsors near 10% open enrollment (± trial volume)

What to do with this National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) page

490 registered trials is a research-attention snapshot, not an endorsement of National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) or any single study.

  • 50 of National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)'s trials are currently recruiting, check each one's own eligibility criteria before contacting a site. Browse recruiting trials
  • Obesity is the condition National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) studies most, compare against other sponsors active in the same condition before evaluating a specific study. See Obesity trials
  • Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide

Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) pipeline card: 490 registered trials from official public datasets. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.