National Heart, Lung, and Blood Institute (NHLBI)

501 total trials 62 currently recruiting 381 completed

National Heart, Lung, and Blood Institute (NHLBI) sponsors 501 registered US clinical trials on ClinicalTrials.gov, 62 of them currently recruiting, and 381 completed. 33 of these trials are in Phase 3-4 (later-stage) and 205 in Phase 1-2 (earlier-stage). The most-studied condition in this pipeline is Atherosclerosis, with 12 trials.

Trial Pipeline

501 total, page 6 of 11

COMPLETED Phase 3

Effectiveness of Etanercept for Idiopathic Pneumonia Syndrome Following Stem Cell Transplantation (BMT CTN 0403)

NCT00421174

TERMINATED Phase 2

Drug Study of Albuterol to Treat Acute Lung Injury

NCT00434993

TERMINATED

Establishing a Repository of Blood and DNA Samples From People With Sickle Cell Disease (Comprehensive Sickle Cell Centers Collaborative Genotype-Phenotype Database and Sample Repository)

NCT00528203

COMPLETED Phase 2

Niacin to Improve Blood Flow in People With Sickle Cell Disease

NCT00508989

COMPLETED

Genes Causing Ebstein's Anomaly

NCT00497705

COMPLETED

Pulmonary Hypertension, Hypoxia and Sickle Cell Disease

NCT00495638

COMPLETED Phase 2

Peptide Vaccinations to Treat Patients With Low-Risk Myeloid Cancers

NCT00488592

TERMINATED Phase 2

Sildenafil Therapy for Pulmonary Hypertension and Sickle Cell Disease

NCT00492531

COMPLETED Phase 1

Imaging of Totally Blocked Arteries

NCT00459446

COMPLETED Phase 2

Stem Cell Transplantation for Patients With Cancers of the Blood

NCT00467961

COMPLETED Phase 2

Effectiveness of an Anger and Stress Management Program on Reducing Blood Pressure Levels in Youth

NCT00508612

COMPLETED Phase 1

Model System for Transient Forearm Blood Vessel Dysfunction

NCT00453531

COMPLETED

Using Differences in Peripheral Blood Leukocyte Gene Expression to Determine Cardiovascular Disease Risk

NCT00613158

COMPLETED Phase 2

Wilm's Tumor 1 (WT1) Peptide Vaccine for High Risk Hematologic Malignancy

NCT00433745

COMPLETED

Role of p53 Gene in Metabolism Regulation in Patients With Li-Fraumeni Syndrome

NCT00406445

COMPLETED

Collection of Heart Tissue Sample During Open Heart Surgery

NCT00423553

COMPLETED

Validation of MRI Measurement of Cardiac Blood Flow

NCT00417625

COMPLETED Phase 2

Rilonacept to Improve Artery Function in Patients With Atherosclerosis

NCT00417417

COMPLETED Phase 2

Dexamethasone to Prevent Oral Chronic Graft-versus-Host Disease

NCT00391170

COMPLETED

Genetic Disorders of Mucociliary Clearance in Nontuberculous Mycobacterial Lung Disease

NCT00368446

COMPLETED Phase 2

Alemtuzumab (Campath) to Treat T-Large Granular Lymphocyte Leukemia

NCT00345345

COMPLETED NA

Catheter-Based Treatment of Cardiovascular Disease

NCT00380016

COMPLETED

Role of Helicobacter Pylori and Its Toxins in Lung and Digestive System Diseases

NCT00366509

COMPLETED Phase 2

Methods to Enhance the Safety and Effectiveness of Stem Cell Transplants

NCT00378534

COMPLETED Phase 1

Lower But More Frequent Dose Rituximab to Treat Chronic Lymphocytic Leukemia

NCT00366418

COMPLETED

Predicting Response to Cardiac Resynchronization Therapy in Heart Failure

NCT00359372

COMPLETED

Cardiovascular Magnetic Resonance Imaging of Pediatric Normal Volunteers

NCT00353899

COMPLETED Phase 1

Cardiopulmonary Function Assessment and NO-Based Therapies for Patients With Hemolysis-Associated Pulmonary Hypertension

NCT00352430

COMPLETED

Genetic and Nutritional Causes of Heart Birth Defects

NCT00368732

COMPLETED

The Link Between Anemia and Deficits in Memory and Attention in Individuals With Sickle Cell Disease

NCT00451919

COMPLETED

Lifetime Risk for Cardiovascular Disease Among Non-White Ethnic Groups

NCT00377702

COMPLETED Phase 1

An Evaluation of Safety and Efficacy of Escalating Doses of AMD3100 to Mobilize CD34+ Cells in Healthy Volunteers

NCT00322127

COMPLETED

Telomere Repair Gene Mutation in Inflammatory Bowel Disease

NCT00353639

TERMINATED Phase 1

Sildenafil to Treat HIV-Associated Pulmonary Hypertension

NCT00327080

COMPLETED

Endothelial Progenitor Cells and Nitric Oxide in Cardiac Rehabilitation Program Participants

NCT00308633

TERMINATED Phase 4

Childhood Asthma Research and Education (CARE) Network Trial - Montelukast or Azithromycin for Reduction of Inhaled Corticosteroids in Childhood Asthma (MARS)

NCT00471809

COMPLETED Phase 2

Atorvastatin to Treat Pulmonary Sarcoidosis

NCT00279708

COMPLETED Phase 1

Safety of Peptide Vaccination for Patients With Myelodysplastic Syndrome

NCT00270452

COMPLETED Phase 1

Hydroxyurea and Erythropoietin to Treat Sickle Cell Anemia

NCT00270478

COMPLETED Phase 3

Rituxan/BEAM vs Bexxar/BEAM in Autologous Hematopoietic Stem Cell Transplant for Non-Hodgkin's Lymphoma (BMTCTN0401)

NCT00329030

COMPLETED Phase 2

Three Immunosuppressive Treatment Regimens for Severe Aplastic Anemia

NCT00260689

COMPLETED Phase 1

The Role of Nitrite in Preconditioning Mediated Tolerance to Ischemic Stress

NCT00250185

COMPLETED Phase 2

Effect of Regular Exercise on Vascular Function and Cardiovascular Risk in a Sedentary Work Force

NCT00246883

COMPLETED Phase 2

Alemtuzumab to Treat Severe Aplastic Anemia

NCT00195624

COMPLETED Phase 2

Treatment for Acute Graft-Versus-Host Disease (BMT CTN 0302)

NCT00224874

COMPLETED Phase 2

Rituximab to Treat Moderate Aplastic Anemia, Pure Red Cell Aplasia, or Diamond Blackfan Anemia

NCT00229619

COMPLETED

Genomics of In-Stent Restenosis

NCT00341562

COMPLETED Phase 3

Eculizumab to Treat Paroxysmal Nocturnal Hemoglobinuria

NCT00130000

COMPLETED Phase 2

A Pilot Study of Alemtuzumab (Campath[R]) in Patients With Myelodysplastic Syndrome

NCT00217594

COMPLETED Phase 2

Acute Myeloid Leukemia T Cell Depletion to Improve Transplants in Adults With Acute Myeloid Leukemia (BMT CTN 0303)

NCT00201240

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Phase Distribution

PhaseTrial count
Phase 1 87
Phase 2 118
Phase 3 29
Phase 4 4

What the Pipeline for National Heart, Lung, and Blood Institute (NHLBI) Shows

According to the ClinicalTrials.gov registry, National Heart, Lung, and Blood Institute (NHLBI) is linked to 501 US clinical trials across every stage of research activity. Of those, 62 studies are currently recruiting, about 12% of the sponsor's indexed portfolio, and 381 are already marked complete, representing roughly 76% of the total.

The phase mix for National Heart, Lung, and Blood Institute (NHLBI) reports 33 late-stage studies (Phase 3 and Phase 4 combined) and 205 earlier-phase studies (Phase 1 and Phase 2).

The top therapeutic focus area indexed for National Heart, Lung, and Blood Institute (NHLBI) is Atherosclerosis with 12 linked trials, and 9 other condition areas appear in the top list above.

How to read these pipeline numbers

Recruiting share is one of the more practical signals here: it reflects how much of a sponsor's research is presently open to new participants, while the completed share indicates the depth of finished work that has already contributed registry results. Both counts come directly from the public ClinicalTrials.gov dataset and are refreshed on the registry side; this page mirrors the latest data pull without altering it.

A portfolio weighted toward Phase 3 usually reflects an organization advancing candidates toward regulatory review, where the research centers on comparative efficacy and broader safety across larger populations. A heavier Phase 1 and Phase 2 tilt generally indicates exploratory work, safety, dosing, and early signal detection, and is common among research-forward sponsors that seed many early programs. Phase 4 entries, when present, track interventions already in real-world use and typically focus on long-term safety, effectiveness across subgroups, or formulation comparisons.

That distribution is a quick read of where the organization concentrates its research attention; it does not imply product availability, market share, or any clinical endorsement. All numbers on this page come from ClinicalTrials.gov maintained by the National Library of Medicine, and counts can shift as new studies are registered or existing ones update their status. This information is provided for reference and educational purposes only, not as medical, investment, or regulatory advice, verify current details directly with ClinicalTrials.gov before relying on any figure here.

Data sourced from official public datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial from this sponsor, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.