H. Lee Moffitt Cancer Center and Research Institute

502 total trials 82 currently recruiting 280 completed

H. Lee Moffitt Cancer Center and Research Institute sponsors 502 registered US clinical trials on ClinicalTrials.gov, 82 of them currently recruiting, and 280 completed. 5 of these trials are in Phase 3-4 (later-stage) and 335 in Phase 1-2 (earlier-stage). The most-studied condition in this pipeline is Prostate Cancer, with 12 trials.

Trial Pipeline

502 total, page 5 of 11

COMPLETED Phase 1

Lymphodepletion Plus Adoptive Cell Therapy With High Dose IL-2 in Adolescent and Young Adult Patients With Soft Tissue Sarcoma

NCT04052334

COMPLETED

Mobile APP Utilization for Enhanced Post-Operative Nutritional Recovery

NCT04091165

COMPLETED Phase 1

IRX-2 Regimen and Durvalumab, for Incurable H&N Squamous Cell Carcinoma

NCT03381183

TERMINATED Phase 2

Study of T-VEC in Locally Advanced Cutaneous Angiosarcoma

NCT03921073

COMPLETED NA

Developing and Testing a Spanish-Language Intervention to Reduce Cancer-Related Sleep Disturbance

NCT04101526

COMPLETED

Novel Exoscope System for 5-ALA Fluorescence-Guided Surgery for Gliomas

NCT04055688

TERMINATED Early Phase 1

Intratumorally-Administered Topotecan Using Convection-Enhanced Delivery in Patients With Grade III/ IV Glioma

NCT03927274

COMPLETED Phase 1

Avelumab With Radiotherapy in Patients With Leptomeningeal Disease

NCT03719768

TERMINATED Phase 2

Ibrutinib and PD-1 Blockade in High Risk Lymphocytic Leukemia

NCT03514017

COMPLETED Phase 2

Avadomide (CC-122) in Combination With Nivolumab in Advanced Melanoma

NCT03834623

TERMINATED Phase 2

Aromatase Inhibitor and Durvalumab in Postmenopausal Breast Cancer

NCT03874325

TERMINATED Phase 1

Dose Escalation Study of Minnelide in Relapsed or Refractory Acute Myeloid Leukemia

NCT03760523

COMPLETED Early Phase 1

Prospective Study of Personalized Approach to Inpatient Patients With Hyperglycemia

NCT03904199

COMPLETED Phase 1

CD40-L Blockade for Prevention of Acute Graft-Versus-Host Disease

NCT03605927

COMPLETED Phase 1

IRX-2 Regimen Combined With Nivolumab in Recurrent/Metastatic Solid Tumors

NCT03758781

COMPLETED Phase 1

Stereotactic Radiation and Nivolumab in the Management of Metastatic Breast Cancer Brain Metastases

NCT03807765

COMPLETED

Emotional Support Messages Following a Cancer Diagnosis

NCT03840109

COMPLETED NA

Development of a Mindfulness-Based Treatment for the Reduction of Alcohol Use and Smoking Cessation

NCT03734666

TERMINATED Phase 2

Immune Response and Potential Booster for Patients Who Have Received HER2-pulsed DC1

NCT03630809

COMPLETED Phase 2

TAS 102 in Combination With Ramucirumab in Advanced, Refractory Gastric or Gastroesophageal Junction (GEJ) Adenocarcinoma

NCT03686488

TERMINATED Phase 1

Radiation and Chemotherapy With Ipilimumab Followed by Nivolumab for Patients With Stage III Unresectable Non-Small Cell Lung Cancer (NSCLC)

NCT03663166

COMPLETED Phase 1

Regorafenib and Nivolumab in Mismatch Repair (MMR) Refractory Colorectal Cancer

NCT03712943

COMPLETED Phase 2

Vyxeos(CPX-351) in Adults w R/R Acute Lymphoblastic Leukemia

NCT03575325

TERMINATED Phase 2

Elotuzumab Plus Lenalidomide (Elo/Rev) for Serologic Relapse/Progression While on Lenalidomide

NCT03411031

COMPLETED NA

Use of a Proliferation Saturation Index to Determine Personalized Radiotherapy for HPV + Oropharyngeal Cancers

NCT03656133

COMPLETED NA

Pharmacogenomic-Guided Antidepressant Drug Prescribing in Cancer Patients

NCT03674138

TERMINATED Phase 2

Adaptive Tyrosine Kinase Inhibitor (TKI) Therapy In Patients With Thyroid Cancer

NCT03630120

COMPLETED Early Phase 1

Applying mHealth to Tobacco-related Health Disparities

NCT03404596

COMPLETED Phase 1

Study of Trametinib + Ceritinib in Patients With Unresectable Melanoma

NCT03501368

COMPLETED NA

Improving Sleep in BMT Survivors

NCT03537963

COMPLETED

Community Colorectal Cancer Awareness, Research, Education & Screening (C-CARES)

NCT03906110

COMPLETED Phase 1

Pembrolizumab and Vorinostat Combined With Temozolomide for Newly Diagnosed Glioblastoma

NCT03426891

TERMINATED Phase 2

Combination Immunotherapy-Ipilimumab-Nivolumab-Dendritic Cell p53 Vac - Patients With Small Cell Lung Cancer (SCLC)

NCT03406715

COMPLETED Phase 1

Pembrolizumab in Combination With Ibrutinib for Advanced, Refractory Colorectal Cancers

NCT03332498

COMPLETED Phase 1

Cetuximab & Nivolumab in Patients With Recurrent/Metastatic Head & Neck Squamous Cell Carcinoma

NCT03370276

COMPLETED Phase 2

Phase II Study of Pembrolizumab and Lenvatinib in Advanced Well-differentiated Neuroendocrine Tumors

NCT03290079

TERMINATED NA

Preoperative Stereotactic Ablative Body Radiotherapy (SABR) for Early-Stage Breast Cancer

NCT03137693

COMPLETED Phase 1

Nivolumab and Tumor Infiltrating Lymphocytes (TIL) in Advanced Non-Small Cell Lung Cancer

NCT03215810

COMPLETED Phase 1

Pirfenidone Combined With Standard First-Line Chemotherapy in Advanced-Stage Lung NSCLC

NCT03177291

COMPLETED Phase 2

Facilitating Smoking Cessation With Reduced Nicotine Cigarettes

NCT02796391

COMPLETED Phase 1

Selinexor Plus High-Dose Melphalan (HDM) Before Autologous Hematopoietic Cell Transplantation for Multiple Myeloma

NCT02780609

COMPLETED Phase 1

Phase I-II Study of Interferon-gamma in Patients With HER-2 Positive Breast Cancer

NCT03112590

COMPLETED NA

Patient Navigation in the Adolescent and Young Adult (AYA) Cancer Population

NCT03176576

COMPLETED Phase 1

A Phase I/II GVHD Prevention Trial Combining Pacritinib With Sirolimus-Based Immune Suppression

NCT02891603

COMPLETED Phase 1

Phase 1b/2 Safety and Efficacy of APR-246 w/Azacitidine for tx of TP53 Mutant Myeloid Neoplasms

NCT03072043

COMPLETED NA

Screen to Save: NCI Colorectal Cancer Outreach & Screening Initiative

NCT05064410

COMPLETED

Refining and Testing the Electronic Social Network Assessment Program (eSNAP)

NCT03026699

COMPLETED Phase 1

Talimogene Laherparepvec in Combination With Neoadjuvant Chemotherapy in Triple Negative Breast Cancer

NCT02779855

COMPLETED Phase 2

Interleukin-2 and Pembrolizumab for Metastatic Kidney Cancer

NCT02964078

COMPLETED

Biobank for African American Prostate Cancer Research in Florida

NCT03232411

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Phase Distribution

PhaseTrial count
Phase 1 167
Phase 2 168
Phase 3 3
Phase 4 2

What the Pipeline for H. Lee Moffitt Cancer Center and Research Institute Shows

According to the ClinicalTrials.gov registry, H. Lee Moffitt Cancer Center and Research Institute is linked to 502 US clinical trials across every stage of research activity. Of those, 82 studies are currently recruiting, about 16% of the sponsor's indexed portfolio, and 280 are already marked complete, representing roughly 56% of the total.

The phase mix for H. Lee Moffitt Cancer Center and Research Institute reports 5 late-stage studies (Phase 3 and Phase 4 combined) and 335 earlier-phase studies (Phase 1 and Phase 2).

The top therapeutic focus area indexed for H. Lee Moffitt Cancer Center and Research Institute is Prostate Cancer with 12 linked trials, and 9 other condition areas appear in the top list above.

How to read these pipeline numbers

Recruiting share is one of the more practical signals here: it reflects how much of a sponsor's research is presently open to new participants, while the completed share indicates the depth of finished work that has already contributed registry results. Both counts come directly from the public ClinicalTrials.gov dataset and are refreshed on the registry side; this page mirrors the latest data pull without altering it.

A portfolio weighted toward Phase 3 usually reflects an organization advancing candidates toward regulatory review, where the research centers on comparative efficacy and broader safety across larger populations. A heavier Phase 1 and Phase 2 tilt generally indicates exploratory work, safety, dosing, and early signal detection, and is common among research-forward sponsors that seed many early programs. Phase 4 entries, when present, track interventions already in real-world use and typically focus on long-term safety, effectiveness across subgroups, or formulation comparisons.

That distribution is a quick read of where the organization concentrates its research attention; it does not imply product availability, market share, or any clinical endorsement. All numbers on this page come from ClinicalTrials.gov maintained by the National Library of Medicine, and counts can shift as new studies are registered or existing ones update their status. This information is provided for reference and educational purposes only, not as medical, investment, or regulatory advice, verify current details directly with ClinicalTrials.gov before relying on any figure here.

Data sourced from official public datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial from this sponsor, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.