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ACTIVE NOT RECRUITING Phase 1

A Study of DS-6000a in Subjects With Advanced Renal Cell Carcinoma and Ovarian Tumors

NCT04707248 · View on ClinicalTrials.gov ↗

Study Summary

This clinical trial will evaluate raludotatug deruxtecan (R-DXd; DS-6000a) in participants with advanced renal cell carcinoma (RCC) and ovarian cancer (OVC). The main goals of this study will be to investigate the recommended dose of R-DXd that can be given safely to participants, assess the adverse events of R-DXd, and evaluate the effectiveness of R-DXd.

Interventions

  • DRUG DS-6000a

Study Locations (13)

Other

  • National Hospital Organization Kyusyu Cancer Center — Fukuoka
  • The Cancer Institute Hospital of Japanese Foundation for Cancer Research — Kōtoku
  • National Hospital Organization Shikoku Cancer Center — Matsuyama
  • Shizuoka Cancer Center — Nakatogari
  • Saitama Medical University International Medical Center — Saitama

Tennessee

  • SCRI Oncology Partners — Nashville
  • Vanderbilt-Ingram Cancer Center — Nashville

Tokyo

  • National Cancer Center Hospital — Chuo Ku
  • National Cancer Center Hospital East — Kashiwa-shi

Arizona

  • Arizona Oncology Associates, PC HOPE (A)A HOPE) — Tucson

Colorado

  • Rocky Mountain Cancer Center — Denver

Florida

  • Florida Cancer Lake Mary — Lake Mary

Oklahoma

  • Oklahoma University — Oklahoma City

Trial Details

FieldValue
Enrollment Target 179 participants
Start Date 2020-12-22
Est. Completion 2026-06-30
Phase Phase 1

Sponsor

Daiichi Sankyo

157 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT04707248

The ClinicalTrials.gov registry entry for NCT04707248 describes a study currently listed as active not recruiting. It is categorized as Phase 1, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 179 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Daiichi Sankyo, which has 157 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 2 conditions, with Renal Cell Carcinoma appearing as the primary indexed condition, and to 1 intervention — of which DS-6000a is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT04707248 reports 13 study locations spanning 7 distinct geographic areas — top geographies include Other, Tennessee, Tokyo. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT04707248 about?

NCT04707248 is a clinical study titled "A Study of DS-6000a in Subjects With Advanced Renal Cell Carcinoma and Ovarian Tumors". This clinical trial will evaluate raludotatug deruxtecan (R-DXd; DS-6000a) in participants with advanced renal cell carcinoma (RCC) and ovarian cancer (OVC). The main goals of this study will be to investigate the recommended dose of R-DXd that can be given safely to participants, assess the adverse...

What is the current status of trial NCT04707248?

This trial is currently active not recruiting. It is a Phase 1 study. The enrollment target is 179 participants. The study started on 2020-12-22. Estimated completion is 2026-06-30.

What conditions does trial NCT04707248 study?

This clinical trial studies the following conditions: Renal Cell Carcinoma, Ovarian Tumor. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT04707248?

The interventions under investigation include: DS-6000a (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT04707248?

This trial is sponsored by Daiichi Sankyo, which has 157 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT04707248 being conducted?

This trial has 13 study locations across Arizona, Colorado, Florida, Oklahoma, Tennessee. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial