Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.

RECRUITING Phase 3

Study of Trastuzumab Deruxtecan Versus Standard of Care Chemotherapy for HER2-Expressing (IHC 3+/2+) Endometrial Cancer

NCT07022483 · View on ClinicalTrials.gov ↗

Study Summary

This study is designed to assess efficacy and safety of T-DXd adjuvant therapy, with or without radiotherapy, post-surgery in anticancer treatment naïve (including neoadjuvant therapy) endometrial cancer with various HER2 expression levels.

Conditions Studied

Interventions

  • DRUG Chemotherapy
  • DRUG Trastuzumab Deruxtecan

Study Locations (20)

Other

  • Beijing Cancer Hospital — Beijing
  • The First Hospital of Jilin University — Changchun
  • West China Second University Hospital, Sichuan University — Chengdu
  • Obstetrics and Gynecology Hospital Affiliated to Zhejiang University School of Medicine — Hangzhou
  • Zhejiang Cancer Hospital — Hangzhou
  • Cancer Hospital of Shandong First Medical University — Jinan
  • Linyi Cancer Hospital — Linyi
  • Jiangxi Maternal and Child Health Hospital — Nanchang
  • Guangxi Medical University Affiliated Tumor Hospital — Nanning
  • Shanghai First Maternity and Infant HospitalShanghai First Maternity and Infant Hospital — Shanghai
  • Shanghai Tenth People's Hospital — Shanghai
  • Tianjin Medical University Cancer Institute & Hospital — Tianjin
  • The First Affiliated Hospital of Wenzhou Medical University — Wenzhou
  • Tongji Hospital, Tongji Medical College, Huazhong University of Science & Technology — Wuhan
  • Union Hospital Tongji Medical College Huazhong University of Science and Technology — Wuhan
  • Yantai Yuhuangding Hospital — Yantai
  • Hyogo Cancer Center — Akashi-shi

Florida

  • Mount Sinai Medical Center — Miami Beach

Louisiana

  • Trials365 LLC — Shreveport

South Dakota

  • Avera Medical Group Gynecologic Oncology Sioux Falls — Sioux Falls

Trial Details

FieldValue
Enrollment Target 710 participants
Start Date 2025-09-30
Est. Completion 2032-03-23
Phase Phase 3

Sponsor

Daiichi Sankyo

157 total trials

Interested in This Trial?

Always speak with your doctor before enrolling in a clinical trial.

Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT07022483

The ClinicalTrials.gov registry entry for NCT07022483 describes a study currently listed as recruiting. It is categorized as Phase 3, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 710 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Daiichi Sankyo, which has 157 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 1 condition, with Endometrial Cancer appearing as the primary indexed condition, and to 2 interventions — of which Chemotherapy is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT07022483 reports 20 study locations spanning 4 distinct geographic areas — top geographies include Other, Florida, Louisiana. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT07022483 about?

NCT07022483 is a clinical study titled "Study of Trastuzumab Deruxtecan Versus Standard of Care Chemotherapy for HER2-Expressing (IHC 3+/2+) Endometrial Cancer". This study is designed to assess efficacy and safety of T-DXd adjuvant therapy, with or without radiotherapy, post-surgery in anticancer treatment naïve (including neoadjuvant therapy) endometrial cancer with various HER2 expression levels.

What is the current status of trial NCT07022483?

This trial is currently recruiting. It is a Phase 3 study. The enrollment target is 710 participants. The study started on 2025-09-30. Estimated completion is 2032-03-23.

What conditions does trial NCT07022483 study?

This clinical trial studies the following conditions: Endometrial Cancer. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT07022483?

The interventions under investigation include: Chemotherapy (DRUG), Trastuzumab Deruxtecan (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT07022483?

This trial is sponsored by Daiichi Sankyo, which has 157 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT07022483 being conducted?

This trial has 20 study locations across Florida, Louisiana, South Dakota. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial