Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
Datopotamab Deruxtecan (Dato-DXd) and Pembrolizumab With or Without Platinum Chemotherapy in 1L Non-Small Cell Lung Cancer (TROPION-Lung07)
NCT05555732 · View on ClinicalTrials.gov ↗
Study Summary
This study is designed to assess the efficacy and safety of datopotamab deruxtecan (Dato-DXd) in combination with pembrolizumab versus pembrolizumab in combination with pemetrexed and platinum chemotherapy in participants with no prior therapy for advanced or metastatic non-squamous non-small cell lung cancer (NSCLC).
Conditions Studied
Interventions
- DRUG Pembrolizumab
- DRUG Carboplatin
- DRUG Cisplatin
- DRUG Pemetrexed
- DRUG Datopotamab Deruxtecan
Study Locations (20)
Florida
- Florida Cancer Specialists - South — Fort Myers
- Cancer Specialist of North Florida — Jacksonville
- Cancer Care Centers of Brevard, Inc. — Palm Bay
- Woodlands Medical Specialists, Pa — Pensacola
- Florida Cancer Specialists-North — St. Petersburg
California
- Hoag Memorial Hospital Prebyterian — Newport Beach
- Compassionate Cancer Care Medical Group — Riverside
- Sansum Clinic — Santa Barbara
- Ronald Reagan UCLA Medical Center — Santa Monica
Massachusetts
- Beth Israel Deaconess Medical Center — Boston
- Dana Farber Cancer Institute; Inv Drg Svc Pharm — Boston
- Dana Farber Cancer Institute At St. Elizabeth'S Medical Center — Brighton
Arizona
- Ironwood Cancer and Research Centers — Chandler
- Arizona Oncology Associates, Pc - Nahoa — Prescott Valley
Maryland
- American Oncology Partners of Maryland — Bethesda
- Maryland Oncology Heamtology P.A. — Columbia
Alabama
- Southern Cancer Center Pc — Daphne
Colorado
- UCHealth Memorial Hospital — Colorado Springs
Georgia
- Emory University - Winship Cancer Institute Wci — Atlanta
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 1,170 participants |
| Start Date | 2023-01-11 |
| Est. Completion | 2029-05-11 |
| Phase | Phase 3 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT05555732
The ClinicalTrials.gov registry entry for NCT05555732 describes a study currently listed as active not recruiting. It is categorized as Phase 3, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 1,170 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Daiichi Sankyo, which has 157 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 1 condition, with Metastatic Non Small Cell Lung Cancer appearing as the primary indexed condition, and to 5 interventions — of which Pembrolizumab is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT05555732 reports 20 study locations spanning 9 distinct geographic areas — top geographies include Florida, California, Massachusetts. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT05555732 about?
NCT05555732 is a clinical study titled "Datopotamab Deruxtecan (Dato-DXd) and Pembrolizumab With or Without Platinum Chemotherapy in 1L Non-Small Cell Lung Cancer (TROPION-Lung07)". This study is designed to assess the efficacy and safety of datopotamab deruxtecan (Dato-DXd) in combination with pembrolizumab versus pembrolizumab in combination with pemetrexed and platinum chemotherapy in participants with no prior therapy for advanced or metastatic non-squamous non-small cell l...
What is the current status of trial NCT05555732?
This trial is currently active not recruiting. It is a Phase 3 study. The enrollment target is 1,170 participants. The study started on 2023-01-11. Estimated completion is 2029-05-11.
What conditions does trial NCT05555732 study?
This clinical trial studies the following conditions: Metastatic Non Small Cell Lung Cancer. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT05555732?
The interventions under investigation include: Pembrolizumab (DRUG), Carboplatin (DRUG), Cisplatin (DRUG), Pemetrexed (DRUG), Datopotamab Deruxtecan (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT05555732?
This trial is sponsored by Daiichi Sankyo, which has 157 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT05555732 being conducted?
This trial has 20 study locations across Alabama, Arizona, California, Colorado, Florida. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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