Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
A Study of Ifinatamab Deruxtecan in Subjects With Pretreated Advanced or Metastatic Esophageal Squamous Cell Carcinoma (ESCC) (IDeate-Esophageal01)
NCT06644781 · View on ClinicalTrials.gov ↗
Study Summary
This study is designed to assess the efficacy and safety of ifinatamab deruxtecan (I-DXd) in patients with unresectable advanced or metastatic esophageal squamous cell carcinoma (ESCC) who have experienced disease progression following treatment with a platinum-based systemic therapy and an immune checkpoint inhibitor (ICI) compared with investigator's choice of chemotherapy (ICC).
Conditions Studied
Interventions
- DRUG Docetaxel
- DRUG Paclitaxel
- DRUG Ifinatamab deruxtecan
- DRUG Irinotecan hydrochloride (HCl)
Study Locations (20)
Other
- Institut Jules Bordet — Brussels
- Cliniques Universitaires Saint-Luc — Brussels
- Antwerp University Hospital — Edegem
- UZ Leuven — Leuven
- Anyang Cancer Hospital — Anyang
- Beijing Cancer Hospital — Beijing
- Jilin Cancer Hospital — Changchun
- Changzhou Cancer Hospital — Changzhou
- Sichuan cancer hospital — Chengdu
- West China Hospital Sichuan University — Chengdu
- Fujian Cancer Hospital — Fuzhou
- Harbin Medical University Cancer Hospital — Harbin
- The First Affiliated Hospital of Fujian Medical University — Hefei
- Jinan Central Hospital — Jinan
Tennessee
- Baptist Cancer Center — Memphis
- SCRI Oncology Partners — Nashville
California
- Providence Medical Foundation — Fullerton
Michigan
- Henry Ford Health System — Detroit
Texas
- John Peter Smith Hospital — Fort Worth
Virginia
- Virginia Cancer Specialists — Fairfax
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 510 participants |
| Start Date | 2025-03-27 |
| Est. Completion | 2029-11-01 |
| Phase | Phase 3 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT06644781
The ClinicalTrials.gov registry entry for NCT06644781 describes a study currently listed as recruiting. It is categorized as Phase 3, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 510 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Daiichi Sankyo, which has 157 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 1 condition, with Esophageal Squamous Cell Carcinoma appearing as the primary indexed condition, and to 4 interventions — of which Docetaxel is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT06644781 reports 20 study locations spanning 6 distinct geographic areas — top geographies include Other, Tennessee, California. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT06644781 about?
NCT06644781 is a clinical study titled "A Study of Ifinatamab Deruxtecan in Subjects With Pretreated Advanced or Metastatic Esophageal Squamous Cell Carcinoma (ESCC) (IDeate-Esophageal01)". This study is designed to assess the efficacy and safety of ifinatamab deruxtecan (I-DXd) in patients with unresectable advanced or metastatic esophageal squamous cell carcinoma (ESCC) who have experienced disease progression following treatment with a platinum-based systemic therapy and an immune c...
What is the current status of trial NCT06644781?
This trial is currently recruiting. It is a Phase 3 study. The enrollment target is 510 participants. The study started on 2025-03-27. Estimated completion is 2029-11-01.
What conditions does trial NCT06644781 study?
This clinical trial studies the following conditions: Esophageal Squamous Cell Carcinoma. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT06644781?
The interventions under investigation include: Docetaxel (DRUG), Paclitaxel (DRUG), Ifinatamab deruxtecan (DRUG), Irinotecan hydrochloride (HCl) (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT06644781?
This trial is sponsored by Daiichi Sankyo, which has 157 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT06644781 being conducted?
This trial has 20 study locations across California, Michigan, Tennessee, Texas, Virginia. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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